Hydrochloric Acid

Hydrochloric Acid

SCHEMBL3763676

Cl.Cl.Nc1nc(N)c(N)c(O)n1

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.31
CASP1 P29466 1/20 0.31
PIK3CG P48736 1/20 0.31
PDPK1 O15530 1/20 0.30
DCPS Q96C86 1/20 0.30
ADORA2A P29274 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL30706492 1.00 CYP1A2 (0.31) CYP1A2CASP1PIK3CGPDPK1DCPS
Hydrochloric Acid SCHEMBL19858971 1.00 CYP1A2 (0.31) CYP1A2CASP1PIK3CGPDPK1DCPS
Hydrochloric Acid SCHEMBL19858970 1.00 CYP1A2 (0.31) CYP1A2CASP1PIK3CGPDPK1DCPS
SCHEMBL33967 0.97 CYP1A2 (0.32) CYP1A2CASP1PIK3CGPDPK1DCPS
SCHEMBL29400765 0.97 CYP1A2 (0.32) CYP1A2CASP1PIK3CGPDPK1DCPS
SCHEMBL28837049 0.94 CYP1A2 (0.31) CYP1A2CASP1PIK3CGPDPK1DCPS
Hydrogen Sulfide SCHEMBL28177577 0.94 CYP1A2 (0.31) CYP1A2CASP1PIK3CGPDPK1DCPS
SCHEMBL6943391 0.94 CYP1A2 (0.31) CYP1A2CASP1PIK3CGPDPK1DCPS
SCHEMBL28067039 0.94 CYP1A2 (0.31) CYP1A2CASP1PIK3CGPDPK1DCPS
SCHEMBL6409173 0.87

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3634365-B1 HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE HENKEL AG & CO KGAA (DE) 2022-08-10 EP claimed
EP-3496818-B1 PROCESS FOR PREPARING HAIR DYE AGENTS HAVING UNILAMELLAR AND MULTILAMELLAR VESICLES HENKEL AG & CO KGAA (DE) 2021-01-20 EP claimed
US-10736827-B2 Hair dye agent having unilamellar and multilamellar vesicles HENKEL AG & CO. KGAA (DE) 2020-08-11 US claimed
US-20200170904-A1 HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE HENKEL AG & CO. KGAA (DE) 2020-06-04 US claimed
EP-3634365-A1 HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE Henkel AG & Co. KGaA (DE) 2020-04-15 EP claimed
US-20190175459-A1 HAIR DYE AGENT HAVING UNILAMELLAR AND MULTILAMELLAR VESICLES HENKEL AG & CO. KGAA (DE) 2019-06-13 US claimed
JP-59186986-A None JP disclosed
EP-3634365-B1 HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE HENKEL AG & CO KGAA (DE) 2022-08-10 EP disclosed
EP-3496818-B1 PROCESS FOR PREPARING HAIR DYE AGENTS HAVING UNILAMELLAR AND MULTILAMELLAR VESICLES HENKEL AG & CO KGAA (DE) 2021-01-20 EP disclosed
US-10736827-B2 Hair dye agent having unilamellar and multilamellar vesicles HENKEL AG & CO. KGAA (DE) 2020-08-11 US disclosed
US-10702459-B2 Hair dye having improved viscosity stability HENKEL AG & CO. KGAA (DE) 2020-07-07 US disclosed
US-20200170904-A1 HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE HENKEL AG & CO. KGAA (DE) 2020-06-04 US disclosed
EP-3634365-A1 HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE Henkel AG & Co. KGaA (DE) 2020-04-15 EP disclosed
EP-0385336-A2 Processes for the preparation of pterin derivatives NISSHIN FLOUR MILLING CO., LTD. (JP) 1990-09-05 EP disclosed
EP-0079574-B1 PROCESS FOR PREPARING BIOPTERIN AND ITS DERIVATIVES KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1987-03-04 EP disclosed
US-4540783-A 1',2'-Diacyl-(6R,S)-5,6,7,8-tetrahydro-L-biopterin and process for preparing the same KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1985-09-10 US disclosed
JP-S59186986-A PREPARATION OF 1',2'-DIACYL-L-BIOPTERIN KANEGAFUCHI CHEM IND CO LTD 1984-10-23 JP disclosed
EP-0079574-A1 Process for preparing biopterin and its derivatives KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1983-05-25 EP disclosed
US-4091087-A IODINATED PTEROYL-DELTA-GLUTAMYL-TYROSINES SMITH KLINE INSTRUMENTS, INC. (US) 1978-05-23 US disclosed
US-3989812-A Folic acid derivatives and use in radio-assay SMITHKLINE INSTRUMENTS, INC. (US) 1976-11-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10736827-B2 Hair dye agent having unilamellar and multilamellar vesicles EXOSC10, ANXA5, ANXA4 CYP1A2 2777/4885CASP1 3088/4885PIK3CG 2027/4885
US-20200170904-A1 HAIR COLORING COMPOSITION WITH IMPROVED SALT TOLERANCE UGCG, ADH1C, ELOVL1 CYP1A2 1162/4885CASP1 4120/4885PIK3CG 1482/4885
US-10702459-B2 Hair dye having improved viscosity stability KRT18, S100B, SHH CYP1A2 2719/4885CASP1 3225/4885PIK3CG 3849/4885
US-20190175459-A1 HAIR DYE AGENT HAVING UNILAMELLAR AND MULTILAMELLAR VESICLES EXOSC10, ANXA5, ANXA4 CYP1A2 2777/4885CASP1 3088/4885PIK3CG 2027/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.