Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Aspartame. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.57 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ANPEP | P15144 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartame SCHEMBL5499340 | 1.00 | ALDH1A1 (0.62) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| Aspartame SCHEMBL8761786 | 1.00 | ALDH1A1 (0.62) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| Aspartame SCHEMBL9019515 | 0.99 | ALDH1A1 (0.61) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| Aspartame SCHEMBL11085391 | 0.99 | ALDH1A1 (0.64) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| Aspartame SCHEMBL10625481 | 0.99 | ALDH1A1 (0.64) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| Aspartame SCHEMBL216238 | 0.99 | ALDH1A1 (0.64) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| Aspartame SCHEMBL900809 | 0.99 | ALDH1A1 (0.64) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| Aspartame SCHEMBL8761655 | 0.99 | ALDH1A1 (0.64) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| Aspartame SCHEMBL8091203 | 0.99 | ALDH1A1 (0.64) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| Aspartame SCHEMBL3637 | 0.99 | ALDH1A1 (0.64) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 258 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115545487-A | Polymorphic power grid dynamic evaluation method and system based on system dynamics | 国网安徽省电力有限公司经济技术研究院 | 2022-12-30 | — | — | CN | claimed |
| CN-216172281-U | Neutralization reaction device for aspartame production | 江苏汉光生物工程有限公司 | 2022-04-05 | — | — | CN | claimed |
| CN-111034986-A | Production method of aspartame | 南通市常海食品添加剂有限公司 | 2020-04-21 | — | — | CN | claimed |
| CN-110894211-A | Production method of high-quality aspartame | 南通市常海食品添加剂有限公司 | 2020-03-20 | — | — | CN | claimed |
| WO-2001079264-A1 | PROCESS FOR PRODUCING α-L-ASPARTYL-L-PHENYLALANINE METHYLESTER HYDROCHLORIDE | DAE SANG CORPORATION (KR) | 2001-10-25 | — | — | WO | claimed |
| CN-1035183-C | Process for preparation of alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride | NUTRASWEET CO (US) | 1997-06-18 | — | — | CN | claimed |
| EP-0581032-B1 | Method for production of alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride | AJINOMOTO KK (JP) | 1997-06-11 | — | — | EP | claimed |
| EP-0516100-B1 | Method of preparing alpha-L-aspartyl-L-phenylalanine methyl ester or its hydrochloride salt | AJINOMOTO KK (JP) | 1996-12-11 | — | — | EP | claimed |
| EP-0582303-B1 | Method for the production of alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride | AJINOMOTO KK (JP) | 1996-12-11 | — | — | EP | claimed |
| US-5530155-A | Process for recovering L-phenylalanine | AJINOMOTO CO., INC. (JP) | 1996-06-25 | — | — | US | claimed |
| US-4778916-A | CONDENSATION OF N-FORMYL-L-ASPARTIC ACID ANHYDRIDE WITH PHENYLALANINE IN BASIC AQUEOUS SOLUTION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1988-10-18 | — | — | US | claimed |
| US-4684745-A | Process for producing α-L-aspartyl-L-phenylalanine methyl ester for its hydrochloride | AJINOMOTO COMPANY INCORPORATED (JP) | 1987-08-04 | — | — | US | claimed |
| US-4677220-A | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester | MONSANTO COMPANY (US) | 1987-06-30 | — | — | US | claimed |
| EP-0221878-A2 | Process for the preparation of alpha-L-aspartyl-L-phenylalanine methyl ester | Monsanto Company (US) | 1987-05-13 | — | — | EP | claimed |
| EP-0200311-A2 | Preparation process of alpha-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1986-11-05 | — | — | EP | claimed |
| EP-0196866-A2 | Preparation process of alpha-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1986-10-08 | — | — | EP | claimed |
| US-4606854-A | Method of preparing α-L-aspartyl-L-phenylalanine methyl ester and its hydrochloride | AJINOMOTO CO., INC. (JP) | 1986-08-19 | — | — | US | claimed |
| EP-0187530-A2 | Process for the preparation of alpha-L-aspartyl-L-phenylalanine methyl ester | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1986-07-16 | — | — | EP | claimed |
| US-4029701-A | Sweetening with hydrohalide salts of dipeptide sweeteners | GENERAL FOODS CORPORATION (US) | 1977-06-14 | — | — | US | claimed |
| US-4017472-A | Process for isolation of aspartyl dipeptide esters | G. D. SEARLE & CO. (US) | 1977-04-12 | — | — | US | claimed |