Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Thiomorpholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiomorpholine SCHEMBL6608263 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL7744897 | 0.96 | HIF1A (0.46) | — | |
| SCHEMBL9873225 | 0.96 | HIF1A (0.42) | — | |
| Thiomorpholine SCHEMBL145846 | 0.96 | — | — | |
| Thiomorpholine SCHEMBL93637 | 0.96 | HIF1A (0.42) | — | |
| Thiomorpholine SCHEMBL2273 | 0.96 | — | — | |
| Thiomorpholine SCHEMBL253450 | 0.92 | — | — | |
| Thiomorpholine SCHEMBL8707518 | 0.92 | — | — | |
| SCHEMBL8935918 | 0.92 | HIF1A (0.50) | — | |
| SCHEMBL1615244 | 0.92 | HIF1A (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102453001-A | Thiomorpholine compound and preparation method and application thereof | INST MATERIA MEDICA CAMS | 2012-05-16 | — | — | CN | claimed |
| CN-117957227-A | Pyridodiazepine derivatives as GABA Aγ1 PAM | 豪夫迈·罗氏有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-113667457-B | Ferroelectric material with second harmonic effect and preparation method thereof | 江西理工大学 | 2022-11-04 | — | — | CN | disclosed |
| CN-113667457-A | Ferroelectric material with second harmonic effect and preparation method thereof | 江西理工大学 | 2021-11-19 | — | — | CN | disclosed |
| CN-108349988-A | tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitor | 卡鲁斯治疗有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-102453001-B | Thiomorpholine compounds and its production and use | INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2016-06-01 | — | — | CN | disclosed |
| CN-104211685-A | Thiomorpholine compounds containing substituted pyrrole alkyl groups | INST MATERIA MEDICA CAMS | 2014-12-17 | — | — | CN | disclosed |
| CN-103420981-A | Substituted-pyrrolidinyl-contained thiomorpholine compounds | INST MATERIA MEDICA CAMS | 2013-12-04 | — | — | CN | disclosed |
| CN-102453001-A | Thiomorpholine compound and preparation method and application thereof | INST MATERIA MEDICA CAMS | 2012-05-16 | — | — | CN | disclosed |
| CN-101675051-A | Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors | WYETH CORP | 2010-03-17 | — | — | CN | disclosed |
| CN-1078461-A | The preparation method of analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1993-11-17 | — | — | CN | disclosed |
| CN-1022185-C | Process for preparing analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1993-09-22 | — | — | CN | disclosed |
| CN-1040791-A | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | SANKYO CO (JP) | 1990-03-28 | — | — | CN | disclosed |
| EP-0314008-A2 | N-substituted aliphatic heterocyclic compounds able to facilitate the passage of active substances through physiological barriers | MEDIOLANUM FARMACEUTICI s.r.l. (IT) | 1989-05-03 | — | — | EP | disclosed |
| EP-0017152-B1 | NOVEL HETEROCYCLIC SUBSTITUTED PYRAZINOYLGUANIDINES, PROCESSES FOR PREPARING AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1983-01-26 | — | — | EP | disclosed |
| US-4246406-A | DIURETICS | MERCK & CO., INC. (US) | 1981-01-20 | — | — | US | disclosed |
| EP-0017152-A1 | Novel heterocyclic substituted pyrazinoylguanidines, processes for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1980-10-15 | — | — | EP | disclosed |
| US-4178371-A | ANALGESIC, NARCOTIC ANTAGONIST OR ANTIDIARRHEAL AGENT | RECKITT & COLMAN PRODUCTS LIMITED (GB) | 1979-12-11 | — | — | US | disclosed |
| US-4045209-A | Substituted ureas as herbicides | ROUSSEL UCLAF (FR) | 1977-08-30 | — | — | US | disclosed |
| US-3975524-A | ANTICOAGULANTS | BOEHRINGER INGELHEIM GMBH (DT) | 1976-08-17 | — | — | US | disclosed |