Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.46 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.46 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.46 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.46 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.44 |
| ▸ | PRKCI known ✓ | P41743 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1013660 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL25246100 | 1.00 | — | — | |
| SCHEMBL1013700 | 0.98 | — | — | |
| Cyanide SCHEMBL28084860 | 0.91 | GAA (0.46) | RAB9ANPC1PKMCFTRGOPC | |
| Propane SCHEMBL10608405 | 0.89 | RAB9A (0.47) | RAB9ANPC1PKMCFTRGOPC | |
| Formic Acid SCHEMBL27671745 | 0.86 | RAB9A (0.49) | RAB9ANPC1PKMLMNAHIF1A | |
| Acrylonitrile SCHEMBL28122959 | 0.84 | GAA (0.49) | RAB9ANPC1PKMCFTRGOPC | |
| SCHEMBL16322245 | 0.81 | ATG4B (0.46) | RAB9ANPC1PKMCFTRGOPC | |
| SCHEMBL9551726 | 0.79 | — | — | |
| SCHEMBL29793056 | 0.77 | KIF11 (0.60) | RAB9ANPC1PKMCFTRGOPC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 245 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105636441-B | The method for preparing Pesticidal compound | 美国陶氏益农公司 | 2018-06-15 | — | — | CN | claimed |
| US-20180099945-A1 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | DOW AGROSCIENCES LLC (US) | 2018-04-12 | — | — | US | claimed |
| US-20180044319-A1 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | DOW AGROSCIENCES LLC (US) | 2018-02-15 | — | — | US | claimed |
| CN-107074775-A | The preparation method of 3 (base of 3 chlorine 1H pyrazoles 1) pyridines | 美国陶氏益农公司 | 2017-08-18 | — | — | CN | claimed |
| CN-107074774-A | The method for preparing 3 (base of 3 chlorine 1H pyrazoles 1) pyridines | 美国陶氏益农公司 | 2017-08-18 | — | — | CN | claimed |
| US-20170226078-A1 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | DOW AGROSCIENCES LLC (US) | 2017-08-10 | — | — | US | claimed |
| EP-3191455-A1 | PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE | Dow AgroSciences LLC (US) | 2017-07-19 | — | — | EP | claimed |
| EP-3186230-A1 | PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE | Dow AgroSciences, LLC (US) | 2017-07-05 | — | — | EP | claimed |
| EP-3183238-A1 | PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE | Dow AgroSciences LLC (US) | 2017-06-28 | — | — | EP | claimed |
| EP-3174856-A1 | PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE | Dow AgroSciences LLC (US) | 2017-06-07 | — | — | EP | claimed |
| US-9115115-B1 | Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine | DOW AGROSCIENCES LLC (US) | 2015-08-25 | — | — | US | claimed |
| US-9108946-B2 | Processes for the preparation of pesticidal compounds | DOW AGROSCIENCES LLC (US) | 2015-08-18 | — | — | US | claimed |
| US-9102654-B2 | Processes for the preparation of pesticidal compounds | DOW AGROSCIENCES LLC (US) | 2015-08-11 | — | — | US | claimed |
| US-9085552-B1 | Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine | DOW AGROSCIENCES LLC (US) | 2015-07-21 | — | — | US | claimed |
| US-9029555-B1 | Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine | DOW AGROSCIENCES LLC (US) | 2015-05-12 | — | — | US | claimed |
| US-9024031-B1 | Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine | DOW AGROSCIENCES LLC (US) | 2015-05-05 | — | — | US | claimed |
| WO-2015058028-A1 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | DOW AGROSCIENCES LLC (US) | 2015-04-23 | — | — | WO | claimed |
| WO-2015058021-A1 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | DOW AGROSCIENCES LLC (US) | 2015-04-23 | — | — | WO | claimed |
| US-20150112078-A1 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | DOW AGROSCIENCES LLC | 2015-04-23 | — | — | US | claimed |
| US-20150112077-A1 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | DOW AGROSCIENCES LLC | 2015-04-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150112078-A1 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | DDT, ACHE, PTMS | PTGS2 973/4885ADRA2A 2400/4885ADRA2B 2402/4885 |
| US-20180044319-A1 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | DDT, ACHE, PTMS | PTGS2 973/4885ADRA2A 2400/4885ADRA2B 2402/4885 |
| US-20170226078-A1 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | DDT, ACHE, PTMS | PTGS2 973/4885ADRA2A 2400/4885ADRA2B 2402/4885 |
| US-20180099945-A1 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | DDT, ACHE, PTMS | PTGS2 973/4885ADRA2A 2400/4885ADRA2B 2402/4885 |
| US-20150112077-A1 | PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS | DDT, ACHE, PTMS | PTGS2 973/4885ADRA2A 2400/4885ADRA2B 2402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.