SCHEMBL4604624

SCHEMBL4604624

NS(=O)(=O)C1CCCN1Cc1csc2ccccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.51
CRHBP P24387 1/20 0.50
CRHR2 Q13324 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
CA1 P00915 2/20 0.47
CA2 P00918 2/20 0.47
DPP4 P27487 1/20 0.43
DPP8 Q6V1X1 1/20 0.43
DPP9 Q86TI2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
CYP2A6 P11509 2/20 0.42
DRD2 P14416 4/20 0.41
DRD4 P21917 4/20 0.41
DRD3 P35462 4/20 0.41
FAAH O00519 1/20 0.41
MTNR1A P48039 1/20 0.40
OPRM1 P35372 2/20 0.40
OPRK1 P41145 2/20 0.40
UTS2R Q9UKP6 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4272983 0.79 CA2 (0.36) CA2DPP4DPP8DPP9OPRM1
SCHEMBL2033381 0.77 CYP1A2 (0.61) CHRNA7CRHBPCRHR2SMN1; SMN2DPP4
SCHEMBL2033378 0.77 CYP1A2 (0.61) CHRNA7CRHBPCRHR2SMN1; SMN2DPP4
SCHEMBL3984965 0.71 CHRNA7 (0.55) CHRNA7CRHBPCRHR2SMN1; SMN2HDAC8
SCHEMBL10210828 0.70 CHRNA7 (0.97) CHRNA7CRHBPCRHR2SMN1; SMN2HDAC8
SCHEMBL807363 0.68 CHRNA7 (1.00) CHRNA7CRHBPCRHR2SMN1; SMN2HDAC8
SCHEMBL807400 0.68 CHRNA7 (0.66) CHRNA7CRHBPCRHR2SMN1; SMN2HDAC8
SCHEMBL15084307 0.68 CHRNA7 (0.66) CHRNA7CRHBPCRHR2SMN1; SMN2HDAC8
SCHEMBL807587 0.66 CHRNA7 (0.61) CHRNA7CRHBPCRHR2SMN1; SMN2HDAC8
SCHEMBL15084319 0.65 CHRNA7 (0.61) CHRNA7CRHBPCRHR2SMN1; SMN2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1794143-B1 NOVEL BENZO-FUSED HETEROARYL SULFAMIDE DERIVATIVES USEFUL AS ANTICONVULSANT AGENTS JANSSEN PHARMACEUTICA NV (BE) 2008-07-09 EP claimed
US-20070293476-A1 CO-THERAPY FOR THE TREATMENT OF EPILEPSY AND RELATED DISORDERS SMITH-SWINTOSKY VIRGINIA L 2007-12-20 US claimed
US-20070191459-A1 Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels JANSSEN PHARMACEUTICA, N.V. (BE) 2007-08-16 US claimed
US-20070191453-A1 USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF SUBSTANCE ABUSE AND ADDICTION SMITH-SWINTOSKY VIRGINIA L 2007-08-16 US claimed
US-20070191451-A1 USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES AS NEUROPROTECTIVE AGENTS SMITH-SWINTOSKY VIRGINIA L 2007-08-16 US claimed
US-20070191452-A1 USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN SMITH-SWINTOSKY VIRGINIA L 2007-08-16 US claimed
US-20070191449-A1 Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression JANSSEN PHARMACEUTICA, N.V. (BE) 2007-08-16 US claimed
US-20070191460-A1 Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Disease Modification / Epileptogenesis SMITH-SWINTOSKY VIRGINIA L 2007-08-16 US claimed
US-20070191450-A1 Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Mania and Bipolar Disorder SMITH-SWINTOSKY VIRGINIA L 2007-08-16 US claimed
US-20070191461-A1 USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MIGRAINE SMITH-SWINTOSKY VIRGINIA L 2007-08-16 US claimed
US-20060276528-A1 Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents ABDEL-MAGID AHMED F 2006-12-07 US claimed
US-20060047001-A1 Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents JANSSEN PHARMACAEUTICA N.V. (BE) 2006-03-02 US claimed
EP-1794143-B1 NOVEL BENZO-FUSED HETEROARYL SULFAMIDE DERIVATIVES USEFUL AS ANTICONVULSANT AGENTS JANSSEN PHARMACEUTICA NV (BE) 2008-07-09 EP disclosed
US-20070293476-A1 CO-THERAPY FOR THE TREATMENT OF EPILEPSY AND RELATED DISORDERS SMITH-SWINTOSKY VIRGINIA L 2007-12-20 US disclosed
US-20070191459-A1 Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels JANSSEN PHARMACEUTICA, N.V. (BE) 2007-08-16 US disclosed
US-20070191453-A1 USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF SUBSTANCE ABUSE AND ADDICTION SMITH-SWINTOSKY VIRGINIA L 2007-08-16 US disclosed
US-20070191461-A1 USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MIGRAINE SMITH-SWINTOSKY VIRGINIA L 2007-08-16 US disclosed
US-20070191450-A1 Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Mania and Bipolar Disorder SMITH-SWINTOSKY VIRGINIA L 2007-08-16 US disclosed
US-20060276528-A1 Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents ABDEL-MAGID AHMED F 2006-12-07 US disclosed
US-20060047001-A1 Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents JANSSEN PHARMACAEUTICA N.V. (BE) 2006-03-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060276528-A1 Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents GABRA5, SULT2A1, SYNGR2 CHRNA7 621/4885CRHBP 4119/4885CRHR2 2389/4885
US-20070191461-A1 USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MIGRAINE SULT2A1, CNR2, FAAH2 CHRNA7 626/4885CRHBP 2768/4885CRHR2 889/4885
US-20070191449-A1 Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression TPH2, SULT2A1, SDHA CHRNA7 509/4885CRHBP 1473/4885CRHR2 180/4885
US-20070191451-A1 USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES AS NEUROPROTECTIVE AGENTS NLN, CTSA, SMN1; SMN2 CHRNA7 693/4885CRHBP 2624/4885CRHR2 1969/4885
US-20060047001-A1 Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents GABRE, GABRB2, GABRA2 CHRNA7 620/4885CRHBP 3751/4885CRHR2 1611/4885
US-20070191460-A1 Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Disease Modification / Epileptogenesis SULT2A1, GABRB2, GABRB1 CHRNA7 964/4885CRHBP 3918/4885CRHR2 1694/4885
US-20070191459-A1 Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels LIPC, GPR119, APOB CHRNA7 4558/4885CRHBP 2995/4885CRHR2 2540/4885
US-20070293476-A1 CO-THERAPY FOR THE TREATMENT OF EPILEPSY AND RELATED DISORDERS GABBR1, SYNGR2, GABBR2 CHRNA7 506/4885CRHBP 2554/4885CRHR2 599/4885
US-20070191450-A1 Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Mania and Bipolar Disorder GABBR1, GABBR2, GABRB2 CHRNA7 522/4885CRHBP 2663/4885CRHR2 887/4885
US-20070191452-A1 USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN OPRL1, SULT2A1, OPRK1 CHRNA7 1053/4885CRHBP 1699/4885CRHR2 215/4885
US-20070191453-A1 USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF SUBSTANCE ABUSE AND ADDICTION SULT2A1, SULT1A1, STS CHRNA7 427/4885CRHBP 2503/4885CRHR2 904/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.