Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Isobutamben. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 3/20 | 0.63 |
| ▸ | ADRB1 known ✓ | P08588 | 3/20 | 0.63 |
| ▸ | ADRB3 known ✓ | P13945 | 3/20 | 0.63 |
| ▸ | MAOA known ✓ | P21397 | 2/20 | 0.62 |
| ▸ | SCN1A known ✓ | P35498 | 2/20 | 0.60 |
| ▸ | SCN2A known ✓ | Q99250 | 2/20 | 0.60 |
| ▸ | SCN3A known ✓ | Q9NY46 | 2/20 | 0.60 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.56 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.51 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.48 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.48 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.48 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.48 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.48 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isobutamben SCHEMBL25178 | 0.98 | ADRB2 (0.65) | ADRB2ADRB1ADRB3LMNACYP1A2 | |
| SCHEMBL110051 | 0.89 | ALDH1A1 (0.64) | ADRB2ADRB1ADRB3TSHRALDH1A1 | |
| SCHEMBL7027777 | 0.87 | ADRB2 (0.65) | ADRB2ADRB1ADRB3LMNACYP1A2 | |
| SCHEMBL27668352 | 0.87 | ALDH1A1 (0.62) | ADRB2ADRB1ADRB3TSHRALDH1A1 | |
| SCHEMBL27668055 | 0.87 | ALDH1A1 (0.62) | ADRB2ADRB1ADRB3TSHRALDH1A1 | |
| SCHEMBL27667934 | 0.87 | ALDH1A1 (0.62) | ADRB2ADRB1ADRB3TSHRALDH1A1 | |
| SCHEMBL369461 | 0.86 | ADRB2 (0.60) | ADRB2ADRB1ADRB3LMNACYP1A2 | |
| SCHEMBL5935394 | 0.86 | ADRB2 (0.68) | ADRB2ADRB1ADRB3LMNACYP1A2 | |
| Ammonia Solution, Strong SCHEMBL8406147 | 0.86 | ADRB2 (0.63) | ADRB2ADRB1ADRB3LMNACYP1A2 | |
| SCHEMBL19762354 | 0.84 | ALDH1A1 (0.55) | ADRB2ADRB1ADRB3LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101553210-A | Method and system for delivering a drug via inhalation | NEXT SAFETY INC (US) | 2009-10-07 | — | — | CN | disclosed |
| EP-1911481-A2 | Methods and systems of delivering medication via inhalation | Next Safety, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| US-20080066739-A1 | METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION | HUNTER, CHARLES ERIC | 2008-03-20 | — | — | US | disclosed |
| US-5261903-A | Composite anesthetic article and method of use | M.D. INC. (US) | 1993-11-16 | — | — | US | disclosed |
| US-5226901-A | Buffering systems; adding sodium bicarbonate | M.D., INC. | 1993-07-13 | — | — | US | disclosed |
| US-5209724-A | Buffering local anesthetic, reducing pain and irritation on injection | M.D., INC. | 1993-05-11 | — | — | US | disclosed |
| US-5149320-A | Using parenteral solution containing sodium bicarbonate and dissolved carbon dioxide | M.D., INC. | 1992-09-22 | — | — | US | disclosed |