Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 6/20 | 0.59 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.59 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.59 |
| ▸ | HTR7 known ✓ | P34969 | 2/20 | 0.51 |
| ▸ | ADRA1A known ✓ | P35348 | 4/20 | 0.48 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.48 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.48 |
| ▸ | DRD4 known ✓ | P21917 | 4/20 | 0.47 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.47 |
| ▸ | ADRA1B known ✓ | P35368 | 3/20 | 0.47 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6435975 | 1.00 | HTR1A (0.59) | HTR1AHTR2BHTR1DHTR7MEN1 | |
| SCHEMBL5371883 | 0.99 | HTR1A (0.60) | HTR1AHTR2BHTR1DHTR7MEN1 | |
| Hydrochloric Acid SCHEMBL6435545 | 0.90 | HTR1A (0.72) | HTR1AHTR2BHTR1DADRA1ADRD2 | |
| Hydrochloric Acid SCHEMBL5391694 | 0.90 | HTR1A (0.72) | HTR1AHTR2BHTR1DADRA1ADRD2 | |
| Hydrochloric Acid SCHEMBL6434436 | 0.89 | HTR1A (0.70) | HTR1AHTR2BHTR1DADRA1ADRD2 | |
| SCHEMBL5372555 | 0.89 | HTR1A (0.73) | HTR1AHTR2BHTR1DADRA1ADRD2 | |
| SCHEMBL5389828 | 0.89 | HTR1A (0.73) | HTR1AHTR2BHTR1DADRA1ADRD2 | |
| Hydrochloric Acid SCHEMBL5375310 | 0.89 | HTR1A (0.70) | HTR1AHTR2BHTR1DADRA1ADRD2 | |
| SCHEMBL5391681 | 0.88 | HTR1A (0.71) | HTR1AHTR2BHTR1DADRA1ADRD2 | |
| Oxalic Acid SCHEMBL5377503 | 0.88 | HTR1A (0.71) | HTR1AHTR2BHTR1DADRA1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309702-B2 | 4-(3-Phenyl-3-carbocycloylpropyl)-1-phenyl- or pyridylpiperazine derivatives: 1-(2-methoxyphenyl)-4-[3-(benzoyl)-3-(phenyl)propyl]piperazine oxalate; serotonin receptor antagonists; Alzheimer's disease | AVERA PHARMACEUTICALS, INC. (US) | 2007-12-18 | — | — | US | disclosed |
| US-7001908-B2 | Arylpiperazines having activity at the serotonin 1A receptor | AVERA PHARMACEUTICALS, INC. (US) | 2006-02-21 | — | — | US | disclosed |
| US-20060009464-A1 | Arylpiperazines having activity at the serotonin 1A receptor | ELI LILLY AND COMPANY | 2006-01-12 | — | — | US | disclosed |
| US-20050282817-A1 | 4-(3-Phenyl-3-carbocycloylpropyl)-1-phenyl- or pyridylpiperazine derivatives: 1-(2-methoxyphenyl)-4-[3-(benzoyl)-3-(phenyl)propyl]piperazine oxalate; serotonin receptor antagonists; obesity | NOKIA CORPORATION (FI) | 2005-12-22 | — | — | US | disclosed |
| US-6946579-B2 | Arylpiperazines having activity at the serotonin 1A receptor | ELI LILLY AND COMPANY (US) | 2005-09-20 | — | — | US | disclosed |
| EP-0924205-B1 | Arylpiperazines having activity at the serotonin 1a receptor | LILLY CO ELI (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1514559-A1 | Arylpiperazines having activity at the serotonin 1a receptor | Eli Lilly and Company (US) | 2005-03-16 | — | — | EP | disclosed |
| US-20040049083-A1 | 3-carbocycle carbonyl-3-phenylpropionaldehyde intermediates and preparation by alkylating a carbocycle benzyl ketone with an allyl halide and oxidizing the product | ELI LILLY AND COMPANY | 2004-03-11 | — | — | US | disclosed |
| US-20040044009-A1 | Drug abuse; cental nervous system disorders; cognition activators | ELI LILLY AND COMPANY | 2004-03-04 | — | — | US | disclosed |
| US-6660859-B2 | Arylpiperzine derivatives are useful for treatment of anxiety, depression, hypertension, cognitive disorders, sexual dysfunction, brain trauma, memory loss, eating disorders, obesity, substance abuse, and obsessive-compulsive diseases | ELI LILLY AND COMPANY | 2003-12-09 | — | — | US | disclosed |
| US-6645967-B2 | Administering to a patient a serotonin reuptake inhibitor in combination with an effective amount of arylpiperazines having activity at the serotonin 1A receptor | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| US-20030027831-A1 | Arylpiperzine derivatives are useful for treatment of anxiety, depression, hypertension, cognitive disorders, sexual dysfunction, brain trauma, memory loss, eating disorders, obesity, substance abuse, and obsessive-compulsive diseases | XU YAO-CHANG (US) | 2003-02-06 | — | — | US | disclosed |
| US-20030008879-A1 | For therapy of symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine; for therapy of anxiety | KOHLMAN DANIEL TIMOTHY (US) | 2003-01-09 | — | — | US | disclosed |
| US-6358958-B2 | MONO OR BICYCLIC ARYL OR HETERARYL SUBSTITUTED PIPERIZIN DERIVATIVES USEFUL FOR TREATING ANXIETY, DEPRESSION, HYPERTENSION, COGNITIVE DISORDER, PSYCHOSIS, SLEEP DISORDER, BRAIN TRAUMA, MEMORY LOSS, DRUG ABUSE, MIGRAINE AND OBESITY | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |
| US-6239135-B1 | ALLEVIATING THE SYMPTOMS OF NICOTINE AND TOBACCO WITHDRAWAL. | ELI LILLY AND COMPANY | 2001-05-29 | — | — | US | disclosed |
| EP-0924205-A1 | Arylpiperazines having activity at the serotonin 1a receptor | ELI LILLY AND COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030027831-A1 | Arylpiperzine derivatives are useful for treatment of anxiety, depression, hypertension, cognitive disorders, sexual dysfunction, brain trauma, memory loss, eating disorders, obesity, substance abuse, and obsessive-compulsive diseases | HTR2C, HTR3C, HCRTR1 | HTR1A 4/4885HTR2B 25/4885HTR1D 5/4885 |
| US-20060009464-A1 | Arylpiperazines having activity at the serotonin 1A receptor | HTR1A, HTR2A, HTR3A | HTR1A 1/4885HTR2B 11/4885HTR1D 9/4885 |
| US-20040049083-A1 | 3-carbocycle carbonyl-3-phenylpropionaldehyde intermediates and preparation by alkylating a carbocycle benzyl ketone with an allyl halide and oxidizing the product | HTR3C, HTR3A, HTR2C | HTR1A 6/4885HTR2B 9/4885HTR1D 7/4885 |
| US-20030008879-A1 | For therapy of symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine; for therapy of anxiety | HTR1A, HTR1B, HTR3A | HTR1A 1/4885HTR2B 12/4885HTR1D 5/4885 |
| US-20040044009-A1 | Drug abuse; cental nervous system disorders; cognition activators | HTR6, HTR1A, CNR1 | HTR1A 2/4885HTR2B 19/4885HTR1D 11/4885 |
| US-20050282817-A1 | 4-(3-Phenyl-3-carbocycloylpropyl)-1-phenyl- or pyridylpiperazine derivatives: 1-(2-methoxyphenyl)-4-[3-(benzoyl)-3-(phenyl)propyl]piperazine oxalate; serotonin receptor antagonists; obesity | HTR3A, HTR3C, HTR1A | HTR1A 3/4885HTR2B 14/4885HTR1D 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.