Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.50 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.39 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29042332 | 0.97 | TSHR (0.47) | TSHRACHECYP3A4TDP1ALDH1A1 | |
| SCHEMBL146928 | 0.97 | TSHR (0.53) | TSHRACHECYP3A4TDP1ALDH1A1 | |
| SCHEMBL31457202 | 0.94 | TSHR (0.50) | TSHRACHECYP3A4TDP1ALDH1A1 | |
| SCHEMBL29083664 | 0.94 | TSHR (0.50) | TSHRACHECYP3A4TDP1ALDH1A1 | |
| SCHEMBL5645150 | 0.94 | TSHR (0.50) | TSHRACHECYP3A4TDP1ALDH1A1 | |
| SCHEMBL1304780 | 0.94 | TSHR (0.50) | TSHRACHECYP3A4TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3223494 | 0.92 | TSHR (0.47) | TSHRACHECYP3A4TDP1ALDH1A1 | |
| Bromide SCHEMBL29042359 | 0.92 | TSHR (0.47) | TSHRACHECYP3A4TDP1ALDH1A1 | |
| Propane SCHEMBL29069359 | 0.89 | TSHR (0.45) | TSHRACHECYP3A4TDP1ALDH1A1 | |
| SCHEMBL3632065 | 0.87 | ACHE (0.43) | TSHRACHECYP3A4TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113004327-B | Ligand based on pyridine structure and preparation method thereof, supported catalyst based on pyridine structure, preparation method and application thereof | 万华化学集团股份有限公司（CN） | 2023-01-13 | — | — | CN | claimed |
| CN-113004327-A | Ligand based on pyridine structure and preparation method thereof, supported catalyst based on pyridine structure, preparation method and application thereof | 万华化学集团股份有限公司 | 2021-06-22 | — | — | CN | claimed |
| CN-111018923-B | Carbohydrate monophosphines, method for the production and use thereof | 东莞市均成高新材料有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-113292711-B | Method for synthesizing fluorescent functional polyester-based amphiphilic polymer | 安阳工学院 | 2023-07-14 | — | — | CN | disclosed |
| CN-113354683-B | Biphosphine ligand, preparation method and application thereof | 万华化学集团股份有限公司 | 2023-05-30 | — | — | CN | disclosed |
| CN-115920974-A | Chromium catalyst precursor, ethylene oligomerization catalyst comprising the same, and method for preparing ethylene oligomer | SK新技术株式会社 | 2023-04-07 | — | — | CN | disclosed |
| CN-113004327-B | Ligand based on pyridine structure and preparation method thereof, supported catalyst based on pyridine structure, preparation method and application thereof | 万华化学集团股份有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |
| CN-111349115-B | PNNP structural ligand, preparation method thereof, ethylene oligomerization catalyst system and application thereof | 万华化学集团股份有限公司 | 2022-09-16 | — | — | CN | disclosed |
| CN-111349116-B | Bipyridine structure ligand, preparation method thereof, catalytic system based on bipyridine structure and application of catalytic system in ethylene oligomerization | 万华化学集团股份有限公司 | 2022-08-05 | — | — | CN | disclosed |
| CN-113101975-B | Multi-phosphine ligand catalyst system and application thereof in ethylene oligomerization reaction | 万华化学集团股份有限公司 | 2022-04-22 | — | — | CN | disclosed |
| CN-112916046-B | Three-way catalyst system and application thereof in ethylene oligomerization reaction | 万华化学集团股份有限公司 | 2022-04-19 | — | — | CN | disclosed |
| WO-2008080969-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2008-07-10 | — | — | WO | disclosed |
| WO-2008065145-A1 | PYRIDINE COMPOUNDS FOR COMBATING PESTS | BASF SE (DE) | 2008-06-05 | — | — | WO | disclosed |
| WO-2007104690-A1 | ASYMMETRIC CATALYTIC HYDROGENATION OF PROCHIRAL KETONES AND ALDEHYDES | SOLVIAS AG (CH) | 2007-09-20 | — | — | WO | disclosed |
| US-7214830-B2 | Process for the preparation of acylphosphines, acyl oxides and acyl sulfides | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2007-05-08 | — | — | US | disclosed |
| US-7094931-B2 | Process for the preparation of acylphosphines, acyl oxides and acyl sulfides | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2006-08-22 | — | — | US | disclosed |
| EP-1135399-B2 | PROCESS FOR PREPARING ACYLPHOSPHINES AND DERIVATIVES | CIBA SC HOLDING AG (CH) | 2006-08-09 | — | — | EP | disclosed |
| US-20060128959-A1 | Process for the preparation of acylphosphines, acyl oxides and acyl sulfides | IGM GROUP B.V. (NL) | 2006-06-15 | — | — | US | disclosed |
| US-20040248855-A1 | Process for the preparation of acylphosphines, acyl oxides and acyl sulfides | IGM GROUP B.V. (NL) | 2004-12-09 | — | — | US | disclosed |
| EP-1135399-B1 | PROCESS FOR PREPARING ACYLPHOSPHINES AND DERIVATIVES | CIBA SC HOLDING AG (CH) | 2002-08-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128959-A1 | Process for the preparation of acylphosphines, acyl oxides and acyl sulfides | AGPS, PHOSPHO1, AGPAT2 | ACHE 1636/4885CA2 790/4885ESR1 3816/4885 |
| US-20040248855-A1 | Process for the preparation of acylphosphines, acyl oxides and acyl sulfides | AGPS, PHOSPHO1, AGPAT2 | ACHE 1715/4885CA2 598/4885ESR1 3848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.