Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNB1 known ✓ | Q14721 | 1/20 | 0.37 |
| ▸ | KCNB2 known ✓ | Q92953 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29129651 | 0.77 | CTSD (0.41) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL6278245 | 0.75 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL7216545 | 0.72 | MEN1 (0.41) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL9542306 | 0.72 | KDM4E (0.41) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL5682092 | 0.72 | MAPT (0.39) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL27432511 | 0.71 | AKR1C3 (0.46) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL19437356 | 0.70 | CXCR2 (0.44) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL3792769 | 0.70 | AKR1C3 (0.44) | ALDH1A1KDM4EHSD17B10LMNAMAPT | |
| SCHEMBL20548792 | 0.68 | MEN1 (0.44) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL860493 | 0.68 | CYP2C19 (0.37) | ALDH1A1KDM4EHPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131330-B1 | CHEMILUMINESCENT SUBSTRATES FOR NEURAMINIDASE, ASSAYS FOR DETECTION OF NEURAMINIDASE AND KITS THEREFOR | APPLERA CORP (US) | 2006-03-08 | — | — | EP | disclosed |
| US-6555698-B1 | A 3-(enzymatically cleavable 2-n-acetylneuraminic acid)spiro 1,2-dioxacyclobutane compound, e.g. spiro(adamantane-3,3'-1,2 -dioxabutane; diagnosis for the influenza virus, respiratory system infections; sensitivity; | TROPIX, INC. | 2003-04-29 | — | — | US | disclosed |
| EP-1131330-A4 | CHEMILUMINESCENT SUBSTRATES FOR NEURAMINIDASE, ASSAYS FOR DETECTION OF NEURAMINIDASE AND KITS THEREFOR | TROPIX INC (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-1131330-A1 | CHEMILUMINESCENT SUBSTRATES FOR NEURAMINIDASE, ASSAYS FOR DETECTION OF NEURAMINIDASE AND KITS THEREFOR | TROPIX, INC. (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000029419-A1 | CHEMILUMINESCENT SUBSTRATES FOR NEURAMINIDASE, ASSAYS FOR DETECTION OF NEURAMINIDASE AND KITS THEREFOR | TROPIX, INC. (US) | 2000-05-25 | — | — | WO | disclosed |
| EP-0619018-B1 | IMPROVED MEMBRANE FOR CHEMILUMINESCENT BLOTTING APPLICATIONS | TROPIX INC (US) | 1998-11-25 | — | — | EP | disclosed |
| EP-0619018-A4 | IMPROVED MEMBRANE FOR CHEMILUMINESCENT BLOTTING APPLICATIONS. | TROPIX INC (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5593828-A | Membrane for chemiluminescent blotting applications | TROPIX, INC. (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0619018-A1 | IMPROVED MEMBRANE FOR CHEMILUMINESCENT BLOTTING APPLICATIONS | TROPIX, INC. (US) | 1994-10-12 | — | — | EP | disclosed |
| US-5336596-A | Polymer coated support; 1,2-dioxetanes as chemiluminescence source | TROPIX, INC. (US) | 1994-08-09 | — | — | US | disclosed |
| WO-1993013405-A1 | IMPROVED MEMBRANE FOR CHEMILUMINESCENT BLOTTING APPLICATIONS | TROPIX, INC. (US) | 1993-07-08 | — | — | WO | disclosed |