Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 known ✓ | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.40 |
| ▸ | KCNH3 known ✓ | Q9ULD8 | 3/20 | 0.39 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11412458 | 1.00 | ALDH1A1 (0.57) | ALDH1A1MAPTL3MBTL1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL11408403 | 1.00 | ALDH1A1 (0.57) | ALDH1A1MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL11293624 | 0.98 | ALDH1A1 (0.59) | ALDH1A1MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL11292065 | 0.98 | ALDH1A1 (0.59) | ALDH1A1MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL11039228 | 0.98 | ALDH1A1 (0.59) | ALDH1A1MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL6938804 | 0.98 | ALDH1A1 (0.59) | ALDH1A1MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL10758238 | 0.98 | ALDH1A1 (0.59) | ALDH1A1MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL12993821 | 0.96 | ALDH1A1 (0.61) | ALDH1A1MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL9468217 | 0.91 | ALDH1A1 (0.52) | ALDH1A1MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL9468140 | 0.91 | ALDH1A1 (0.52) | ALDH1A1MAPTL3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071822-B | Organopolysiloxane, cosmetic, and method for producing organopolysiloxane | 信越化学工业株式会社 | 2021-10-22 | — | — | CN | disclosed |
| EP-3438159-B1 | ORGANOPOLYSILOXANE, COSMETIC MATERIAL, AND METHOD FOR PRODUCING ORGANOPOLYSILOXANE | SHINETSU CHEMICAL CO (JP) | 2021-03-31 | — | — | EP | disclosed |
| US-10662294-B2 | Organopolysiloxane, cosmetics, and method for manufacturing organopolysiloxane | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2020-05-26 | — | — | US | disclosed |
| EP-2921518-B1 | ORGANOPOLYSILOXANE HAVING AMIDE GROUP, AND COSMETIC MATERIAL CONTAINING SAME | SHINETSU CHEMICAL CO (JP) | 2019-06-19 | — | — | EP | disclosed |
| US-20190077920-A1 | ORGANOPOLYSILOXANE, COSMETICS, AND METHOD FOR MANUFACTURING ORGANOPOLYSILOXANE | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2019-03-14 | — | — | US | disclosed |
| EP-3438159-A1 | ORGANOPOLYSILOXANE, COSMETIC MATERIAL, AND METHOD FOR PRODUCING ORGANOPOLYSILOXANE | Shin-Etsu Chemical Co., Ltd. (JP) | 2019-02-06 | — | — | EP | disclosed |
| EP-2921518-A1 | ORGANOPOLYSILOXANE HAVING AMIDE GROUP, AND COSMETIC MATERIAL CONTAINING SAME | Shin-Etsu Chemical Co., Ltd. (JP) | 2015-09-23 | — | — | EP | disclosed |
| EP-2280040-B1 | Organopolysiloxane having amide group, and cosmetic material containing same | SHINETSU CHEMICAL CO (JP) | 2015-04-15 | — | — | EP | disclosed |
| US-8912354-B2 | Organopolysiloxane and cosmetic containing the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2014-12-16 | — | — | US | disclosed |
| US-8398964-B2 | Organopolysiloxane having amide group, and cosmetic material containing same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2013-03-19 | — | — | US | disclosed |
| US-20060280712-A1 | Cosmetic | KANEBO COSMETICS | 2006-12-14 | — | — | US | disclosed |
| US-20060222615-A1 | Cosmetic preparation | KANEBO COSMETICS INC. (JP) | 2006-10-05 | — | — | US | disclosed |
| US-6984390-B2 | Silicone compound and cosmetic preparation | SHIN-ETSU CHEMICAL CO. LTD. (JP) | 2006-01-10 | — | — | US | disclosed |
| EP-1607081-A1 | COSMETIC PREPARATION | Kanebo Cosmetics, Inc. (JP) | 2005-12-21 | — | — | EP | disclosed |
| EP-1481660-A1 | Cosmetic | Shin-Etsu Chemical Co., Ltd. (JP) | 2004-12-01 | — | — | EP | disclosed |
| EP-1291376-A1 | SILICONE POLYMER, SILICONE COMPOSITION, AND COSMETIC PREPARATION CONTAINING THE SAME | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2003-03-12 | — | — | EP | disclosed |
| EP-1291377-A1 | SILICONE COMPOUND AND COSMETIC PREPARATION | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2003-03-12 | — | — | EP | disclosed |
| EP-1213006-A1 | COSMETICS | KANEBO, LTD. (JP) | 2002-06-12 | — | — | EP | disclosed |
| EP-0331833-B1 | WATER-IN-OIL EMULSION TYPE COSMETICS | SHISEIDO COMPANY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| EP-0331833-A1 | Water-in-oil emulsion type cosmetics | SHISEIDO COMPANY LIMITED (JP) | 1989-09-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077920-A1 | ORGANOPOLYSILOXANE, COSMETICS, AND METHOD FOR MANUFACTURING ORGANOPOLYSILOXANE | PIEZO1, H1-0, TRPA1 | HDAC3 1578/4885HDAC1 825/4885HDAC2 600/4885 |
| US-10662294-B2 | Organopolysiloxane, cosmetics, and method for manufacturing organopolysiloxane | PIEZO1, H1-0, TRPA1 | HDAC3 1578/4885HDAC1 825/4885HDAC2 600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.