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Hydrochloric Acid

Hydrochloric Acid

SCHEMBL6054980

C[Si](C)(CSc1ccccc1)N[Zr]N[Si](C)(C)CSc1ccccc1.Cl.Cl.Cl

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MAOA known ✓ P21397 1/20 0.40
▸ MAOB known ✓ P27338 1/20 0.40
▸ ALDH1A1 P00352 2/20 0.40
▸ MAPK1 P28482 1/20 0.40
▸ MTNR1A P48039 4/20 0.37
▸ MTNR1B P49286 4/20 0.37
▸ FFAR1 O14842 1/20 0.34
▸ CYP3A4 P08684 2/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33
▸ CYP2C9 P11712 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ HIF1A Q16665 1/20 0.33
▸ NPC1 O15118 2/20 0.33
▸ RAB9A P51151 2/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ LMNA P02545 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.32
▸ MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6055062 0.98 ALDH1A1 (0.41) ALDH1A1MAPK1MAOAMAOBMTNR1A
Hydrochloric Acid SCHEMBL6054975 0.74 ALDH1A1 (0.40) ALDH1A1MAPK1MAOAMAOBMTNR1A
SCHEMBL113038 0.73 ALDH1A1 (0.52) ALDH1A1MAPK1MAOAMAOBMTNR1A
SCHEMBL6054977 0.73 ALDH1A1 (0.39) ALDH1A1MAPK1MAOAMAOBMTNR1A
SCHEMBL2420121 0.70 ALDH1A1 (0.48) ALDH1A1MAPK1MAOAMAOBMTNR1A
SCHEMBL29901626 0.68 ALDH1A1 (0.57) ALDH1A1MAPK1MAOAMAOBMTNR1A
SCHEMBL15638476 0.66 ALDH1A1 (0.48) ALDH1A1MAPK1MAOAMAOBMTNR1A
SCHEMBL19611324 0.65 ALDH1A1 (0.43) ALDH1A1MAPK1MAOAMAOBMTNR1A
SCHEMBL1097615 0.65 HPGD (0.45) ALDH1A1MAPK1MAOAMAOBFFAR1
SCHEMBL2420674 0.65 ALDH1A1 (0.52) ALDH1A1MAPK1MAOAMAOBMTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1379561-B1 OLEFIN POLYMERIZATION PROCESS USING TRANSITION METAL COMPLEXES DOW GLOBAL TECHNOLOGIES INC (US) 2006-06-14 — — EP claimed
EP-1379561-A2 TRANSITION METAL DONOR COMPLEXES AND OLEFIN POLYMERIZATION PROCESS DOW GLOBAL TECHNOLOGIES INC. (US) 2004-01-14 — — EP claimed
US-6627711-B2 Using coordination polymerization catalyst DOW GLOBAL TECHNOLOGIES INC. 2003-09-30 — — US claimed
WO-2002081530-A2 TRANSITION METAL DONOR COMPLEXES AND OLEFIN POLYMERIZATION PROCESS DOW GLOBAL TECHNOLOGIES INC. (US) 2002-10-17 — — WO claimed
US-20020147287-A1 Transition metal donor complexes and olefin polymerization process DOW GLOBAL TECHNOLOGIES INC. 2002-10-10 — — US claimed
EP-1379561-B1 OLEFIN POLYMERIZATION PROCESS USING TRANSITION METAL COMPLEXES DOW GLOBAL TECHNOLOGIES INC (US) 2006-06-14 — — EP disclosed
EP-1379561-A2 TRANSITION METAL DONOR COMPLEXES AND OLEFIN POLYMERIZATION PROCESS DOW GLOBAL TECHNOLOGIES INC. (US) 2004-01-14 — — EP disclosed
US-6627711-B2 Using coordination polymerization catalyst DOW GLOBAL TECHNOLOGIES INC. 2003-09-30 — — US disclosed
WO-2002081530-A2 TRANSITION METAL DONOR COMPLEXES AND OLEFIN POLYMERIZATION PROCESS DOW GLOBAL TECHNOLOGIES INC. (US) 2002-10-17 — — WO disclosed
US-20020147287-A1 Transition metal donor complexes and olefin polymerization process DOW GLOBAL TECHNOLOGIES INC. 2002-10-10 — — US disclosed