Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Norcodeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 8/20 | 0.63 |
| ▸ | OPRK1 known ✓ | P41145 | 6/20 | 0.63 |
| ▸ | OPRD1 known ✓ | P41143 | 5/20 | 0.63 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.63 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.63 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.63 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.46 |
| ▸ | MRGPRX2 | Q96LB1 | 5/20 | 0.98 |
| ▸ | MAPT | P10636 | 1/20 | 0.98 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.62 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.58 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norcodeine SCHEMBL7593070 | 0.99 | MRGPRX2 (0.96) | MRGPRX2MAPTOPRM1OPRK1OPRD1 | |
| Norcodeine SCHEMBL24541888 | 0.99 | MRGPRX2 (1.00) | MRGPRX2MAPTOPRM1OPRK1OPRD1 | |
| Norcodeine SCHEMBL29776979 | 0.99 | MRGPRX2 (1.00) | MRGPRX2MAPTOPRM1OPRK1OPRD1 | |
| Norcodeine SCHEMBL18462800 | 0.99 | MRGPRX2 (1.00) | MRGPRX2MAPTOPRM1OPRK1OPRD1 | |
| Norcodeine SCHEMBL12638889 | 0.99 | MRGPRX2 (1.00) | MRGPRX2MAPTOPRM1OPRK1OPRD1 | |
| Norcodeine SCHEMBL16922132 | 0.99 | MRGPRX2 (1.00) | MRGPRX2MAPTOPRM1OPRK1OPRD1 | |
| Norcodeine SCHEMBL120271 | 0.99 | MRGPRX2 (1.00) | MRGPRX2MAPTOPRM1OPRK1OPRD1 | |
| Norcodeine SCHEMBL120270 | 0.99 | MRGPRX2 (1.00) | MRGPRX2MAPTOPRM1OPRK1OPRD1 | |
| Norcodeine SCHEMBL4856570 | 0.98 | MRGPRX2 (0.98) | MRGPRX2MAPTOPRM1OPRK1OPRD1 | |
| Codeine SCHEMBL20703798 | 0.89 | OPRM1 (0.83) | MRGPRX2MAPTOPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000065-B1 | PREPARATION OF OXYMORPHONE, OXYCODONE AND DERIVATIVES | PENICK CORP (US) | 2005-03-16 | — | — | EP | disclosed |
| EP-1000065-A4 | PREPARATION OF OXYMORPHONE, OXYCODONE AND DERIVATIVES | PENICK CORP (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-1000065-A1 | PREPARATION OF OXYMORPHONE, OXYCODONE AND DERIVATIVES | Penick Corporation (US) | 2000-05-17 | — | — | EP | disclosed |
| US-6013796-A | SIMPLIFICATION, EFFICIENCY, NONTOXIC | PENICK CORPORATION (US) | 2000-01-11 | — | — | US | disclosed |
| US-6008355-A | OXIDIZING CODEINE TO FORM CODEINONE, CONVERTING CODEINONE TO OXYCODONE IN A TWO STEP ONE POT REACTION: REACTING CODEINONE WITH HYDROGEN PEROXIDE IN WATER IN PRESENCE OF AN ACID TO FORM 14-HYDROXYCODEINONE THEN HYDROGENATING THE INTERMEDIATE | PENICK CORPORATION (US) | 1999-12-28 | — | — | US | disclosed |
| US-6008354-A | PROTECTING HYDROXY GROUP OF MORPHINE IN 3 AND 6 POSITION, DEMETHYLATING N-METHYL ON 17 POSITION AND HYDROLIZING THE ACYL GROUP, FORMING 17-BENZYL-3(O)PROTECTED GROUP, OXIDIZING TO FORM INTERMEDIATE, HYDROGENATION OF INTERMEDIATE | PENICK CORPORATION (US) | 1999-12-28 | — | — | US | disclosed |
| US-5952495-A | REACTING WITH HYDROGEN PEROXIDE AT A TEMPERATURE FROM 15.DEGREE. C. TO ABOUT 70.DEGREE. C. IN THE PRESENCE OF AN ACID AND AN AQUEOUS SOLVENT; FORMING A KEY INTERMEDIATE FOR IMPORTANT NARCOTIC ANALGESICS AND ANTAGONISTS | PENICK CORPORATION (US) | 1999-09-14 | — | — | US | disclosed |
| US-5948788-A | Normorphine and normorphinone derivatives | PENICK CORPORATION (US) | 1999-09-07 | — | — | US | disclosed |
| US-5922876-A | REACTING MORPHINE WITH ACYL HALIDE OR ANHYDRIDE TO FORM 3-ACYLMORPHINE, OXIDIZING HYDROXY GROUP OF ACYLMORPHINE WITH AN OXIDIZING AGENT, REACTING THE INTERMEDIATE WITH HYDROGEN PEROXIDE AND AN ACID, ACYLATING, HYDROGENATING AND HYDROLYSIS | PENICK CORPORATION (US) | 1999-07-13 | — | — | US | disclosed |
| US-5869669-A | REACTING WITH AN OXIDIZING AGENT IN THE PRESENCE OF A WEAK ACID | PENICK CORPORATION (US) | 1999-02-09 | — | — | US | disclosed |
| WO-1999002529-A1 | PREPARATION OF OXYMORPHONE, OXYCODONE AND DERIVATIVES | PENICK CORPORATION (US) | 1999-01-21 | — | — | WO | disclosed |