Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.37 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.32 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.32 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.32 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.32 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.32 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | BCHE known ✓ | P06276 | 1/20 | 0.31 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.31 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.31 |
| ▸ | PRCP | P42785 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7561178 | 0.98 | HTR2A (0.38) | HTR2AGPR3ACHECHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL6732020 | 0.97 | HTR2A (0.37) | HTR2AGPR3ACHECHRM2HTR1A | |
| SCHEMBL20986960 | 0.96 | HTR2A (0.39) | HTR2AGPR3ACHECHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL6295601 | 0.93 | HTR2A (0.37) | HTR2AGPR3ACHECHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL6732026 | 0.93 | HTR2A (0.37) | HTR2AGPR3ACHECHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL6295669 | 0.83 | GPR3 (0.32) | HTR2AGPR3ACHECHRM2HTR1A | |
| SCHEMBL7152500 | 0.81 | GPR3 (0.32) | HTR2AGPR3ACHECHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL6727342 | 0.80 | CYP3A4 (0.34) | HTR2AGPR3ACHECHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL6731375 | 0.80 | USP2 (0.33) | ACHECHRM2HTR1AADRA2ACHRM1 | |
| SCHEMBL7627897 | 0.79 | ACHE (0.34) | HTR2AGPR3ACHECHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852660-B2 | Solid metallocene catalyst system | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2005-02-08 | — | — | US | claimed |
| US-20030144436-A1 | Coorination catalyst for polyalpha-olefins | MITCHELL KENT E (US) | 2003-07-31 | — | — | US | claimed |
| US-6534609-B2 | Making by combining an organoaluminoxane and a metallocene having olefinic unsaturated substituent(s) in an aliphatic liquid, prepolymerizing olefin(s) to produce a prepolymerized solid catalyst and separating from the liquid | CHEVRON PHILLIPS CHEMICAL COMPANY LP | 2003-03-18 | — | — | US | claimed |
| US-20020177676-A1 | Method for making and using a metallocene catalyst system | CHEVRON PHILLIPS CHEMICAL COMPANY LP, A DELAWARE LIMITED PARTNERSHIP | 2002-11-28 | — | — | US | claimed |
| WO-2002072641-A1 | METHOD FOR MAKING AND USING A METALLOCENE CATALYST SYSTEM | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2002-09-19 | — | — | WO | claimed |
| WO-1999043724-A1 | METHOD FOR POLYMERIZING MONOMERS TO PRODUCE LINEAR, LOW DENSITY POLYMER | PHILLIPS PETROLEUM COMPANY (US) | 1999-09-02 | — | — | WO | claimed |
| WO-1998052686-A1 | METHOD FOR MAKING AND USING A PREPOLYMERIZED OLEFIN POLYMERIZATION CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1998-11-26 | — | — | WO | claimed |
| EP-0685495-B1 | Method for using a supported metallocene catalyst system | PHILLIPS PETROLEUM CO (US) | 1998-04-08 | — | — | EP | claimed |
| US-5498581-A | OLEFIN POLYMERIZATION | PHILLIPS PETROLEUM COMPANY (US) | 1996-03-12 | — | — | US | claimed |
| EP-0685495-A1 | Method for making and using a supported metallocene catalyst system | PHILLIPS PETROLEUM COMPANY (US) | 1995-12-06 | — | — | EP | claimed |
| US-20050171305-A1 | Solid metallocene catalyst system | MITCHELL KENT E (US) | 2005-08-04 | — | — | US | disclosed |
| US-6852660-B2 | Solid metallocene catalyst system | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2005-02-08 | — | — | US | disclosed |
| US-6746981-B2 | OLEFIN POLYMERIZATION CATALYSTS WITH PRODUCTIVITY WHEN FRESH OF >/= 18,000 GRAMS OF POLYETHYLENE PER GRAM OF CATALYST IN ONE HOUR, AND A SPECIFIC SURFACE AREA OF </= 20 M2/G | ALBEMARLE CORPORATION | 2004-06-08 | — | — | US | disclosed |
| US-6730758-B2 | ADDITION POLYMERIZATION OF ALPHA-OLEFIN HYDROCARBON IN PRESENCE OF SELF-SUPPORTED VINYLOLEFIN-PREPOLYMERIZED CATALYST | ALBEMARLE CORPORATION | 2004-05-04 | — | — | US | disclosed |
| EP-1037931-B1 | CATALYST COMPOSITIONS OF ENHANCED PRODUCTIVITY | ALBEMARLE CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-1999043724-A1 | METHOD FOR POLYMERIZING MONOMERS TO PRODUCE LINEAR, LOW DENSITY POLYMER | PHILLIPS PETROLEUM COMPANY (US) | 1999-09-02 | — | — | WO | disclosed |
| WO-1999029738-A1 | CATALYST COMPOSITIONS OF ENHANCED PRODUCTIVITY | ALBEMARLE CORPORATION (US) | 1999-06-17 | — | — | WO | disclosed |
| WO-1998052686-A1 | METHOD FOR MAKING AND USING A PREPOLYMERIZED OLEFIN POLYMERIZATION CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1998-11-26 | — | — | WO | disclosed |
| EP-0685495-B1 | Method for using a supported metallocene catalyst system | PHILLIPS PETROLEUM CO (US) | 1998-04-08 | — | — | EP | disclosed |
| US-5498581-A | OLEFIN POLYMERIZATION | PHILLIPS PETROLEUM COMPANY (US) | 1996-03-12 | — | — | US | disclosed |