Leucine

Leucine

SCHEMBL67322

CC(C)CC(N)C(=O)O.Cl

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PTGS1 known ✓ P23219 1/20 0.46
SLC7A5 Q01650 1/20 0.95
SLC1A2 P43004 7/20 0.71
SLC1A3 P43003 6/20 0.71
SLC1A1 P43005 7/20 0.60
GRIK1 P39086 7/20 0.50
GRIK2 Q13002 4/20 0.50
GGT1 P19440 2/20 0.48
RNPEP Q9H4A4 1/20 0.48
GRIA2 P42262 2/20 0.47
GRIA4 P48058 2/20 0.47
GRIK3 Q13003 2/20 0.47
GRIK5 Q16478 2/20 0.47
GRIA1 P42261 1/20 0.47
SLC7A11 Q9UPY5 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL247522 1.00 SLC7A5 (0.95) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL28611427 1.00 SLC7A5 (0.95) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL15951718 1.00 SLC7A5 (0.95) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL16893974 1.00 SLC7A5 (0.95) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL16893976 1.00 SLC7A5 (0.95) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
D-Leucine SCHEMBL3338788 1.00 SLC7A5 (0.95) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL27850644 1.00 SLC7A5 (0.95) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL4594997 0.97 SLC7A5 (0.90) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL25241602 0.97 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL20362356 0.97

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 187 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116496026-A Composite material for improving reinforcement and carbonization resistance of alkali-activated cementing material and preparation method thereof 东南大学 2023-07-28 CN claimed
EP-3799864-B1 ESSENTIALLY SODIUM-FREE EFFERVESCENT SOLID PHARMACEUTICAL COMPOSITIONS INTAS PHARMACEUTICALS LTD (IN) 2023-03-01 EP claimed
EP-4041199-A1 ESSENTIALLY SODIUM-FREE EFFERVESCENT SOLID PHARMACEUTICAL COMPOSITIONS Intas Pharmaceuticals Ltd. (IN) 2022-08-17 EP claimed
US-20220226368-A1 ESSENTIALLY SODIUM-FREE EFFERVESCENT SOLID PHARMACEUTICAL COMPOSITIONS INTAS PHARMACEUTICALS LIMTED (IN) 2022-07-21 US claimed
CN-112760279-A Mesenchymal stem cell culture medium 圣美基因科技(北京)有限公司 2021-05-07 CN claimed
WO-2021064636-A1 ESSENTIALLY SODIUM-FREE EFFERVESCENT SOLID PHARMACEUTICAL COMPOSITIONS INTAS PHARMACEUTICALS LTD. (IN) 2021-04-08 WO claimed
EP-3799864-A1 ESSENTIALLY SODIUM-FREE EFFERVESCENT SOLID PHARMACEUTICAL COMPOSITIONS Intas Pharmaceuticals Limited (IN) 2021-04-07 EP claimed
EP-3082778-B1 STABLE LIQUID FILLED HARD CAPSULE COMPRISING BETA-HYDROXY-BETA-METHYLBUTYRIC ACID CAPSUGEL BELGIUM NV (BE) 2019-04-03 EP claimed
US-20150197483-A1 METHODS AND COMPOSITIONS FOR MAKING AN AMINO ACID TRIHYDROCHLORIDE WARSAW ORTHOPEDIC, INC. (US) 2015-07-16 US claimed
CN-103951572-A Separation and purification process for producing branched chain amino acid by using fermentation method WUXI JINGHAI AMINO ACID CO LTD 2014-07-30 CN claimed
EP-1254092-B1 RESOLUTION OF DL-RACEMIC MIXTURES DEGUSSA (DE) 2004-01-21 EP claimed
US-6673942-B1 PREFERENTIAL CRYSTALLIZATION, PHYSICAL SEPARATION DEGUSSA AG (DE) 2004-01-06 US claimed
EP-1254092-A1 RESOLUTION OF DL-RACEMIC MIXTURES Degussa AG (DE) 2002-11-06 EP claimed
WO-2001058835-A1 RESOLUTION OF DL-RACEMIC MIXTURES DEGUSSA AG (DE) 2001-08-16 WO claimed
EP-0719148-B1 ORAL WATER SOLUBLE PHARMACEUTICAL COMPOSITIONS CONTAINING ESTRONE DERIVATIVE AND CALCIUM SALT DEGHENGHI ROMANO (CH) 1998-02-18 EP claimed
EP-0719148-A1 ORAL WATER SOLUBLE PHARMACEUTICAL COMPOSITIONS CONTAINING ESTRONE DERIVATIVE AND CALCIUM SALT DEGHENGHI, Romano (CH) 1996-07-03 EP claimed
US-5480574-A 2-aminocarboxylic acid hydrochloride compositions for removal of hard-water deposits SINGERMAN GARY M (US) 1996-01-02 US claimed
WO-1995007701-A1 ORAL WATER SOLUBLE PHARMACEUTICAL COMPOSITIONS CONTAINING ESTRONE DERIVATIVE AND CALCIUM SALT DEGHENGHI ROMANO (CH) 1995-03-23 WO claimed
US-20260041620-A1 NOVEL AMINO ACID BASED SALTS, COMPOSITIONS AND METHODS FOR TREATING SKIN AND IMPROVING SKIN REJUVENATION AND LONGEVITY SYTHEON LTD (US) 2026-02-12 US disclosed
US-3960942-A Leucine isoleucine separation SOCIETE D'ASSISTANCE TECHNIQUE POUR PRODUITS (CH) 1976-06-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150197483-A1 METHODS AND COMPOSITIONS FOR MAKING AN AMINO ACID TRIHYDROCHLORIDE ALKBH3, AADAT, ALKBH1 PTGS1 2378/4885SLC7A5 1032/4885SLC1A2 412/4885
US-20260041620-A1 NOVEL AMINO ACID BASED SALTS, COMPOSITIONS AND METHODS FOR TREATING SKIN AND IMPROVING SKIN REJUVENATION AND LONGEVITY TYR, ARG2, BCAT2 PTGS1 2707/4885SLC7A5 180/4885SLC1A2 492/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.