Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 0.74 |
| ▸ | OPRD1 known ✓ | P41143 | 6/20 | 0.74 |
| ▸ | OPRK1 known ✓ | P41145 | 4/20 | 0.74 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.74 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.74 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.74 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.66 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.74 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.66 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14516209 | 0.99 | OPRM1 (0.75) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL1685975 | 0.99 | OPRM1 (0.75) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL2351367 | 0.90 | OPRD1 (0.73) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL28786036 | 0.90 | OPRD1 (0.69) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Ethylmorphine SCHEMBL220710 | 0.89 | OPRD1 (0.79) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| SCHEMBL8978975 | 0.89 | OPRM1 (0.70) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Ethylmorphine SCHEMBL17747970 | 0.88 | OPRM1 (0.79) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Ethylmorphine SCHEMBL29845657 | 0.88 | OPRM1 (0.79) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Ethylmorphine SCHEMBL15757784 | 0.88 | OPRD1 (0.80) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Ethylmorphine SCHEMBL24971 | 0.88 | OPRD1 (0.80) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6777190-B1 | Crosstalk inhibitors and their uses | BIOSITE, INC. | 2004-08-17 | — | — | US | disclosed |
| US-6297060-B1 | APPARATUS FOR DETECTION AND SEPARATION OF PREFERENTIAL PARTICLE IN SAMPLE | BIOSITE DIAGNOSTICS, INC. | 2001-10-02 | — | — | US | disclosed |
| EP-0579767-B1 | NOVEL CONJUGATES AND ASSAYS FOR SIMULTANEOUS DETECTION OF MULTIPLE LIGANDS | BIOSITE DIAGNOSTICS INC (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-0988547-A1 | NON-COMPETITIVE THRESHOLD LIGAND-RECEPTOR ASSAYS | BIOSITE DIAGNOSTICS INC. (US) | 2000-03-29 | — | — | EP | disclosed |
| EP-0447154-B1 | Device for ligand-receptor methods | BIOSITE DIAGNOSTICS INC (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5939272-A | SIMPLE, RAPID QUALITATIVE OR QUANTITATIVE ANALYSIS OF TARGET LIGAND USING BOTH LIGAND RECEPTORS AND LIGAND RECEPTORS CONJUGATED TO SIGNAL DEVELOPMENT ELEMENTS; SIGNAL ONLY GENERATED WHEN TARGET CONCENTRATION IS ABOVE THRESHOLD | BIOSITE DIAGNOSTICS INCORPORATED (US) | 1999-08-17 | — | — | US | disclosed |
| US-5922615-A | FOR HETEROGEOUS LIGAND-RECEPTOR ASSAYS PARTICULARLY IMMUNOCHROMATOGRAPHY SEPARATIONS | BIOSITE DIAGNOSTICS INCORPORATED (US) | 1999-07-13 | — | — | US | disclosed |
| EP-0635019-B1 | OPIATE DERIVATIVES AND PROTEIN AND POLYPEPTIDE OPIATE DERIVATIVE CONJUGATES AND LABELS | BIOSITE DIAGNOSTICS INC (US) | 1999-05-26 | — | — | EP | disclosed |
| EP-0585310-B1 | CROSSTALK INHIBITORS AND THEIR USES | BIOSITE DIAGNOSTICS INC (US) | 1999-03-17 | — | — | EP | disclosed |
| US-5851776-A | Conjugates and assays for simultaneous detection of multiple ligands | BIOSITE DIAGNOSTICS, INC. (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0635019-A4 | — | — | 1995-02-01 | — | — | EP | disclosed |
| EP-0635019-A1 | NOVEL OPIATE DERIVATIVES AND PROTEIN AND POLYPEPTIDE OPIATE DERIVATIVE CONJUGATES AND LABELS | BIOSITE DIAGNOSTICS INC. (US) | 1995-01-25 | — | — | EP | disclosed |
| EP-0585310-A1 | CROSSTALK INHIBITORS AND THEIR USES | BIOSITE DIAGNOSTICS INC. (US) | 1994-03-09 | — | — | EP | disclosed |
| EP-0579767-A1 | NOVEL CONJUGATES AND ASSAYS FOR SIMULTANEOUS DETECTION OF MULTIPLE LIGANDS | BIOSITE DIAGNOSTICS INC. (US) | 1994-01-26 | — | — | EP | disclosed |
| WO-1993020079-A1 | NOVEL OPIATE DERIVATIVES AND PROTEIN AND POLYPEPTIDE OPIATE DERIVATIVE CONJUGATES AND LABELS | BIOSITE DIAGNOSTICS INCORPORATED (US) | 1993-10-14 | — | — | WO | disclosed |
| WO-1992018866-A1 | NOVEL CONJUGATES AND ASSAYS FOR SIMULTANEOUS DETECTION OF MULTIPLE LIGANDS | BIOSITE DIAGNOSTICS INCORPORATED (US) | 1992-10-29 | — | — | WO | disclosed |
| WO-1992018868-A1 | CROSSTALK INHIBITORS AND THEIR USES | BIOSITE DIAGNOSTICS INCORPORATED (US) | 1992-10-29 | — | — | WO | disclosed |
| US-5089391-A | Immunoassays, quantitative analysis | BIOSITE DIAGNOSTICS, INC. (US) | 1992-02-18 | — | — | US | disclosed |
| WO-1991013998-A1 | BIOASSAY DEVICE WITH NON-ABSORBENT TEXTURED CAPILLARY SURFACE | BIOSITE DIAGNOSTICS, INC. (US) | 1991-09-19 | — | — | WO | disclosed |
| EP-0378391-A2 | Threshold ligand-receptor assay | BIOSITE DIAGNOSTICS INC. (US) | 1990-07-18 | — | — | EP | disclosed |