Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE known ✓ | P06276 | 4/20 | 0.59 |
| ▸ | KCNH2 known ✓ | Q12809 | 3/20 | 0.53 |
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.52 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.52 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.52 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.52 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.52 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.52 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.52 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.52 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.52 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.50 |
| ▸ | OPRD1 known ✓ | P41143 | 1/20 | 0.50 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.50 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL329300 | 0.98 | MAPT (0.66) | MAPTBCHEKCNH2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10756078 | 0.96 | MAPT (0.59) | MAPTBCHEKCNH2MEN1KMT2A | |
| SCHEMBL9768710 | 0.96 | MAPT (0.63) | MAPTBCHEKCNH2MEN1KMT2A | |
| Bromide SCHEMBL11611692 | 0.96 | MAPT (0.63) | MAPTBCHEKCNH2MEN1KMT2A | |
| Water SCHEMBL28273899 | 0.96 | MAPT (0.63) | MAPTBCHEKCNH2MEN1KMT2A | |
| SCHEMBL9485158 | 0.94 | MAPT (0.61) | MAPTBCHEKCNH2MEN1KMT2A | |
| SCHEMBL172516 | 0.94 | MAPT (0.60) | MAPTBCHEKCNH2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11489606 | 0.92 | KCNH2 (0.64) | MAPTBCHEKCNH2OPRM1DRD3 | |
| Hydrochloric Acid SCHEMBL6668969 | 0.92 | KCNH2 (0.64) | MAPTBCHEKCNH2OPRM1DRD3 | |
| Hydrochloric Acid SCHEMBL7178813 | 0.92 | KCNH2 (0.64) | MAPTBCHEKCNH2OPRM1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11504448-B2 | High-impact, transparent prosthesis material having a low residual MMA content | KULZER GMBH (DE) | 2022-11-22 | — | — | US | claimed |
| CN-108472411-B | High impact toughness transparent prosthetic materials with low residual MMA content | 古莎有限公司 | 2021-10-01 | — | — | CN | claimed |
| US-20200289705-A1 | HIGH-IMPACT, TRANSPARENT PROSTHESIS MATERIAL HAVING A LOW RESIDUAL MMA CONTENT | KULZER GMBH (DE) | 2020-09-17 | — | — | US | claimed |
| EP-3373991-B1 | HIGH-IMPACT, TRANSPARENT PROSTHESIS MATERIAL HAVING A LOW RESIDUAL MMA CONTENT | KULZER & CO GMBH (DE) | 2020-07-01 | — | — | EP | claimed |
| EP-3373991-A1 | HIGH-IMPACT, TRANSPARENT PROSTHESIS MATERIAL HAVING A LOW RESIDUAL MMA CONTENT | Kulzer GmbH (DE) | 2018-09-19 | — | — | EP | claimed |
| CN-108472411-A | High impact toughness transparent prosthetic materials with low residual MMA content | 古莎有限公司 | 2018-08-31 | — | — | CN | claimed |
| CN-108101799-A | A kind of high-efficient production technology of glycine | 严世佳 | 2018-06-01 | — | — | CN | claimed |
| WO-2017081244-A1 | HIGH-IMPACT, TRANSPARENT PROSTHESIS MATERIAL HAVING A LOW RESIDUAL MMA CONTENT | HERAEUS KULZER GMBH (DE) | 2017-05-18 | — | — | WO | claimed |
| EP-3164165-A1 | AUTO-POLYMERIZABLE PROSTHETIC MATERIAL AND POLYMERIZED, FRACTURE-TOUGH PROSTHETIC MATERIAL WITH INCREASED COLOUR STABILITY | Heraeus Kulzer GmbH (DE) | 2017-05-10 | — | — | EP | claimed |
| CN-106535949-A | Auto-polymerizable prosthetic material and polymerized, fracture-tough prosthetic material with increased colour stability | 贺利氏古萨有限公司 | 2017-03-22 | — | — | CN | claimed |
| WO-2016001236-A1 | AUTO-POLYMERIZABLE PROSTHETIC MATERIAL AND POLYMERIZED, FRACTURE-TOUGH PROSTHETIC MATERIAL WITH INCREASED COLOUR STABILITY | HERAEUS KULZER GMBH (DE) | 2016-01-07 | — | — | WO | claimed |
| US-12605307-B2 | Dental composite material | KULZER GMBH (DE) | 2026-04-21 | — | — | US | disclosed |
| US-12365811-B2 | Polymerizable composition | KULZER GMBH (DE) | 2025-07-22 | — | — | US | disclosed |
| US-20250092176-A1 | THIOL URETHANE GROUP-CONTAINING POLYMERIZABLE COMPOSITION | KULZER GMBH (DE) | 2025-03-20 | — | — | US | disclosed |
| US-20240352274-A2 | POLYMERIZABLE COMPOSITION | KULZER GMBH (DE) | 2024-10-24 | — | — | US | disclosed |
| US-20120309864-A1 | DENTURE BASE MATERIAL THAT IS FRACTURE-RESISTANT AFTER CURING AND IS OBTAINED FROM AUTOPOLYMERIZING OR COLD-POLYMERIZING COMPOSITIONS | HERAEUS KULZER GMBH (DE) | 2012-12-06 | — | — | US | disclosed |
| EP-2529762-A2 | Prosthetic base material that is break-resistant after hardening, derived from autopolymerising or cold polymerising compounds | Heraeus Kulzer GmbH (DE) | 2012-12-05 | — | — | EP | disclosed |
| EP-2422824-A2 | Basic prosthesis material, in particular for dental prosthetics | Retec Kunststofftechnik GmbH (DE) | 2012-02-29 | — | — | EP | disclosed |
| US-7459106-B2 | Materials, methods, and uses for photochemical generation of acids and/or radical species | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-12-02 | — | — | US | disclosed |
| US-20050173683-A1 | Materials, methods, and uses for photochemical generation of acids and/or radical species | THE ARIZ BD OF REGENTS ON BEHALF OF THE UNIV OF AZ (US) | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250092176-A1 | THIOL URETHANE GROUP-CONTAINING POLYMERIZABLE COMPOSITION | TST, MTHFD2, TMT1A | BCHE 3454/4885KCNH2 4241/4885OPRM1 895/4885 |
| US-12605307-B2 | Dental composite material | ARCN1, CAD, ITGA1 | BCHE 4873/4885KCNH2 1914/4885OPRM1 1293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.