Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 known ✓ | P21453 | 2/20 | 0.33 |
| ▸ | S1PR4 known ✓ | O95977 | 1/20 | 0.30 |
| ▸ | S1PR3 known ✓ | Q99500 | 1/20 | 0.30 |
| ▸ | S1PR5 known ✓ | Q9H228 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.36 |
| ▸ | FDPS | P14324 | 2/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.32 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.30 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.30 |
| ▸ | GPR183 | P32249 | 1/20 | 0.30 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10611254 | 1.00 | LMNA (0.49) | LMNASMPD1FDPSS1PR1DNM1 | |
| SCHEMBL2710658 | 0.98 | LMNA (0.50) | LMNASMPD1FDPSS1PR1SPHK2 | |
| Fluoride SCHEMBL10882602 | 0.96 | LMNA (0.49) | LMNASMPD1FDPSS1PR1SPHK2 | |
| SCHEMBL10529239 | 0.94 | LMNA (0.50) | LMNASMPD1FDPSS1PR1SPHK2 | |
| Hydrochloric Acid SCHEMBL1335628 | 0.91 | LMNA (0.41) | LMNA | |
| SCHEMBL4433953 | 0.86 | LMNA (0.40) | LMNA | |
| SCHEMBL20210773 | 0.86 | LMNA (0.36) | LMNA | |
| SCHEMBL6708475 | 0.83 | LMNA (0.34) | LMNADNM1 | |
| SCHEMBL6708581 | 0.83 | LMNA (0.34) | LMNADNM1 | |
| SCHEMBL6706833 | 0.83 | LMNA (0.34) | LMNADNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 172 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190037849-A1 | COMPOSITION CONTAINING AN ORGANOSILANE AND A PHOTOCATALYST, AND METHODS OF TREATING FLOWERING PLANTS INFECTED WITH A BACTERIAL DISEASE USING THE COMPOSITION | Nano Photo Sciences, LLC | 2019-02-07 | — | — | US | claimed |
| US-10117435-B2 | Composition containing an organosilane and a photocatalyst, and methods of treating flowering plants infected with a bacterial disease using the composition | Nano Photo Sciences, LLC (US) | 2018-11-06 | — | — | US | claimed |
| WO-2016138446-A1 | A COMPOSITION CONTAINING AN ORGANOSILANE AND A PHOTOCATALYST, AND METHODS OF TREATING FLOWERING PLANTS INFECTED WITH A BACTERIAL DISEASE USING THE COMPOSITION | Nano Photo Sciences, LLC (US) | 2016-09-01 | — | — | WO | claimed |
| US-20160249621-A1 | COMPOSITION CONTAINING AN ORGANOSILANE AND A PHOTOCATALYST, AND METHODS OF TREATING FLOWERING PLANTS INFECTED WITH A BACTERIAL DISEASE USING THE COMPOSITION | Nano Photo Sciences, LLC | 2016-09-01 | — | — | US | claimed |
| US-20160128333-A1 | ANTIMICROBIAL QUATERNARY AMMONIUM ORGANOSILANE COATINGS | QORE SYSTEMS | 2016-05-12 | — | — | US | claimed |
| US-8735618-B2 | Solvent-free organosilane quaternary ammonium compositions, method of making and use | RESOURCE DEVELOPMENT L.L.C. (US) | 2014-05-27 | — | — | US | claimed |
| EP-2566874-A2 | SOLVENT-FREE ORGANOSILANE QUATERNARY AMMONIUM COMPOSITIONS, METHOD OF MAKING AND USE | Resource Development L.L.C. (US) | 2013-03-13 | — | — | EP | claimed |
| US-8257780-B2 | Therapeutic composition containing an organosilane quaternary compound and hydrogen peroxide for treating skin disorders and methods of using | RESOURCE DEVELOPMENT L.L.C. (US) | 2012-09-04 | — | — | US | claimed |
| US-20120125226-A1 | Solvent-Free Organosilane Quaternary Ammonium Compositions, Method of Making and Use | RESOURCE DEVELOPMENT L.L.C. (US) | 2012-05-24 | — | — | US | claimed |
| EP-1787650-B1 | A therapeutic composition containing an organosilane quaternary compound and hydrogen peroxide for treating skin disorders | RESOURCE DEV LLC (US) | 2012-05-02 | — | — | EP | claimed |
| US-6613755-B2 | Disinfecting skin, hair or nails with water soluble compound such as 3-(trimethoxysilyl)propyloctadecyldimethyl ammonium chloride or 3-(trimethoxysilyl)propyldidecylmethyl ammonium chloride | COATING SYSTEMS LABORATORIES, INC. | 2003-09-02 | — | — | US | claimed |
| US-20020141959-A1 | Antimicrobial skin preparations containing organosilane quaternaries | COATING SYSTEMS LABORATORIES, INC. (US) | 2002-10-03 | — | — | US | claimed |
| WO-2000072850-A1 | FOOT CARE COMPOSITIONS CONTAINING QUATERNARY AMMONIUM ORGANOSILANES | COATING SYSTEMS LABORATORIES, INC. (US) | 2000-12-07 | — | — | WO | claimed |
| WO-2000054587-A1 | ANTIMICROBIAL SKIN PREPARATIONS CONTAINING ORGANOSILANE QUATERNARIES | COATING SYSTEMS LABORATORIES, INC. (US) | 2000-09-21 | — | — | WO | claimed |
| EP-0279623-B1 | SILANE MICROEMULSIONS | DOW CORNING CORPORATION (US) | 1993-07-14 | — | — | EP | claimed |
| US-4842766-A | Silane microemulsions | DOW CORNING CORPORATION (US) | 1989-06-27 | — | — | US | claimed |
| EP-0279623-A2 | Silane microemulsions | DOW CORNING CORPORATION (US) | 1988-08-24 | — | — | EP | claimed |
| EP-0108853-B1 | 3-(TRIMETHOXYSILYL)PROPYLDIDECYLMETHYL AMMONIUM SALTS AND METHOD OF INHIBITING GROWTH OF MICROORGANISMS THEREWITH | Klein, Stewart E. (US) | 1986-02-26 | — | — | EP | claimed |
| EP-0108853-A1 | 3-(Trimethoxysilyl)propyldidecylmethyl ammonium salts and method of inhibiting growth of microorganisms therewith | Klein, Stewart E. (US) | 1984-05-23 | — | — | EP | claimed |
| US-4394378-A | BACTERICIDES, FUNGICIDES | CARAGEST/A.G. (CH) | 1983-07-19 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120125226-A1 | Solvent-Free Organosilane Quaternary Ammonium Compositions, Method of Making and Use | VDAC1, CUTA, HVCN1 | S1PR1 2220/4885S1PR4 2763/4885S1PR3 2340/4885 |
| US-20160128333-A1 | ANTIMICROBIAL QUATERNARY AMMONIUM ORGANOSILANE COATINGS | QARS1, GATD3, ACMSD | S1PR1 4665/4885S1PR4 4630/4885S1PR3 4596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.