Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.50 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.50 |
| ▸ | OPRM1 known ✓ | P35372 | 3/20 | 0.37 |
| ▸ | OPRD1 known ✓ | P41143 | 3/20 | 0.37 |
| ▸ | OPRK1 known ✓ | P41145 | 3/20 | 0.37 |
| ▸ | BCHE known ✓ | P06276 | 3/20 | 0.36 |
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.35 |
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.35 |
| ▸ | GRIN2D known ✓ | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B known ✓ | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 known ✓ | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B known ✓ | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C known ✓ | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11526249 | 0.83 | MAPT (0.50) | MAPTKDM4EL3MBTL1ALDH1A1LMNA | |
| SCHEMBL14877314 | 0.83 | ESR1 (0.46) | ESR1ESR2MAPTKDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL933510 | 0.81 | MAPT (0.53) | MAPTKDM4EL3MBTL1ALDH1A1LMNA | |
| SCHEMBL2121111 | 0.79 | MAPT (0.50) | MAPTKDM4EL3MBTL1ALDH1A1LMNA | |
| SCHEMBL194697 | 0.79 | BCHE (0.42) | ESR1ESR2MAPTKDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL28962287 | 0.77 | GABRA1 (0.47) | ESR1ESR2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL11667015 | 0.76 | ALDH1A1 (0.56) | KDM4EL3MBTL1ALDH1A1LMNAHTT | |
| Hydrochloric Acid SCHEMBL11352010 | 0.76 | GABRA1 (0.46) | ESR1ESR2MAPTKDM4EL3MBTL1 | |
| SCHEMBL170383 | 0.75 | GABRA1 (0.48) | ESR1ESR2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1733365 | 0.75 | GABRA1 (0.48) | ESR1ESR2MAPTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230086736-A1 | MICROEMULSION-BASED VACCINE DELIVERY SYSTEM, PREPARATION METHOD THEREFOR AND USE THEREOF | SICHUAN UNIVERSITY (CN) | 2023-03-23 | — | — | US | disclosed |
| EP-4098250-A1 | MICROEMULSION-BASED VACCINE DELIVERY SYSTEM, PREPARATION METHOD THEREFOR AND USE THEREOF | Sichuan University (CN) | 2022-12-07 | — | — | EP | disclosed |
| US-10844145-B2 | Method for producing an electrode material | EVONIK OPERATIONS GMBH (DE) | 2020-11-24 | — | — | US | disclosed |
| WO-2020017631-A1 | POLYMER PARTICLES AND METHOD FOR PRODUCING POLYMER PARTICLES | 株式会社クラレ | 2020-01-23 | — | — | WO | disclosed |
| EP-3464392-B1 | METHOD FOR PRODUCING AN ELECTRODE MATERIAL | EVONIK OPERATIONS GMBH (DE) | 2019-12-18 | — | — | EP | disclosed |
| US-20190177445-A1 | METHOD FOR PRODUCING AN ELECTRODE MATERIAL | EVONIK DEGUSSA GMBH (DE) | 2019-06-13 | — | — | US | disclosed |
| US-8779087-B2 | Method for producing aliphatic polycarbonate | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2014-07-15 | — | — | US | disclosed |
| EP-1752474-B1 | METHOD FOR PRODUCING CROSSLINKED POLY(METH)ACRYLATE COMPOUND | SUMITOMO SEIKA CHEMICALS (JP) | 2013-06-12 | — | — | EP | disclosed |
| US-20120123066-A1 | METHOD FOR PRODUCING ALIPHATIC POLYCARBONATE | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2012-05-17 | — | — | US | disclosed |
| EP-2433976-A1 | METHOD FOR PRODUCING ALIPHATIC POLYCARBONATE | Sumitomo Seika Chemicals CO. LTD. (JP) | 2012-03-28 | — | — | EP | disclosed |
| US-7816457-B2 | Method for producing crosslinked poly(meth)acrylate compound | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2010-10-19 | — | — | US | disclosed |
| US-20080319149-A1 | Method for Producing Crosslinked Poly (Meth) Acrylate Compound | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2008-12-25 | — | — | US | disclosed |
| EP-1752474-A1 | METHOD FOR PRODUCING CROSSLINKED POLY(METH)ACRYLATE COMPOUND | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2007-02-14 | — | — | EP | disclosed |