Pelrinone

Pelrinone

SCHEMBL124976

Cc1nc(=O)c(C#N)c(NCc2cccnc2)[nH]1.Cl

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Pelrinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4A known ✓ P27815 1/20 0.70
PDE4B known ✓ Q07343 1/20 0.70
PDE4C known ✓ Q08493 1/20 0.70
PDE4D known ✓ Q08499 1/20 0.70
GAA known ✓ P10253 3/20 0.40
ROCK2 known ✓ O75116 1/20 0.40
CSF1R known ✓ P07333 1/20 0.40
ALDH1A1 P00352 7/20 0.47
HPGD P15428 5/20 0.47
KDM4E B2RXH2 4/20 0.47
LMNA P02545 2/20 0.46
TSHR P16473 2/20 0.46
MAPK10 P53779 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
HTT P42858 1/20 0.46
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
POLB P06746 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
PGK1 P00558 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pelrinone SCHEMBL783978 0.99 PDE4A (0.71) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL7289643 0.87 PDE4A (0.59) PDE4APDE4BPDE4CPDE4DALDH1A1
Hydrochloric Acid SCHEMBL7288081 0.87 PDE4A (0.52) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL10813332 0.87 PDE4A (0.60) PDE4APDE4BPDE4CPDE4DALDH1A1
Hydrochloric Acid SCHEMBL7281579 0.86 PDE4A (0.58) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL7289958 0.86 PDE4A (0.64) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL7289446 0.85 PDE4A (0.53) PDE4APDE4BPDE4CPDE4DALDH1A1
Hydrochloric Acid SCHEMBL7292375 0.85 PDE4A (0.57) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL7291924 0.85 PDE4A (0.52) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL7281876 0.85 PDE4A (0.59) PDE4APDE4BPDE4CPDE4DALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 542 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250161298-A1 METHODS OF TREATING, AMELIORATING, OR PREVENTING HEART FAILURE, AND METHODS OF PROMOTING HEART MUSCLE GROWTH UNIV YALE (US) 2025-05-22 US claimed
WO-2023164452-A2 METHODS OF TREATING, AMELIORATING, OR PREVENTING HEART FAILURE, AND METHODS OF PROMOTING HEART MUSCLE GROWTH YALE UNIVERSITY (US) 2023-08-31 WO claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20260144935-A1 DRIVE ASSEMBLY FOR A DRUG DELIVERY DEVICE AND RELATED METHODS AMGEN INC. (US) 2026-05-28 US disclosed
EP-4240450-B1 DRUG DELIVERY DEVICE ASSEMBLY AND ACCESSORY FOR DRUG DELIVERY DEVICE AMGEN INC (US) 2026-05-20 EP disclosed
US-20260124394-A1 DRUG DELIVERY DEVICES, COMPONENTS FOR USE WITHIN DRUG DELIVERY DEVICES, AND METHODS OF OPERATING DRUG DELIVERY DEVICES AMGEN INC (US) 2026-05-07 US disclosed
US-12618859-B2 Methods and systems for automated syringe quality evaluation AMGEN INC. (US) 2026-05-05 US disclosed
US-12616795-B2 Drug delivery device and methods of delivering a drug AMGEN INC. (US) 2026-05-05 US disclosed
WO-2026090381-A1 DRUG DELIVERY DEVICE AND RELATED METHODS AMGEN INC. (US) 2026-04-30 WO disclosed
EP-0445190-B1 PHARMACEUTICAL PRODUCT HAVING, IN PARTICULAR, A CARDIAC TROPISM COMPRISING A NITRURO COMPLEX OF A TRANSITION METAL AND PROCESS FOR PREPARATION THEREOF CIS BIO INTERNATIONAL (FR) 1993-09-15 EP disclosed
EP-0320805-B1 ACYLATED BENZILIC ACID DERIVATIVES FOR THE REGULATION OF THE TONUS OF THE URINARY BLADDER SCHAPER & BRÜMMER GMBH & CO. KG (DE) 1992-03-04 EP disclosed
EP-0445190-A1 PHARMACEUTICAL PRODUCT HAVING, IN PARTICULAR, A CARDIAC TROPISM COMPRISING A NITRURO COMPLEX OF A TRANSITION METAL AND PROCESS FOR PREPARATION THEREOF. CIS BIO INT (FR) 1991-09-11 EP disclosed
WO-1990006137-A1 PHARMACEUTICAL PRODUCT HAVING, IN PARTICULAR, A CARDIAC TROPISM COMPRISING A NITRURO COMPLEX OF A TRANSITION METAL AND PROCESS FOR PREPARATION THEREOF CIS BIO INTERNATIONAL (FR) 1990-06-14 WO disclosed
EP-0364584-A1 ANTIDOTE FOR ORGANIC PHOSPHORUS COMPOUND POISONING KIEVSKY NAUCHNO-ISSLEDOVATELSKY INSTITUT FARMAKOLOGII I TOXIKOLOGII (SU) 1990-04-25 EP disclosed
EP-0342474-A2 Use of diazepinones for the preparation of a medicament for therapy of microcirculatory disorders Dr. Karl Thomae GmbH (DE) 1989-11-23 EP disclosed
EP-0320805-A2 Acylated benzilic acid derivatives for the regulation of the tonus of the urinary bladder SCHAPER & BRÜMMER GMBH & CO. KG (DE) 1989-06-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12616795-B2 Drug delivery device and methods of delivering a drug ABCC1, USE1, CRH PDE4A 960/4885PDE4B 1027/4885PDE4C 591/4885
US-20260124394-A1 DRUG DELIVERY DEVICES, COMPONENTS FOR USE WITHIN DRUG DELIVERY DEVICES, AND METHODS OF OPERATING DRUG DELIVERY DEVICES PER2, CRY1, CRH PDE4A 421/4885PDE4B 286/4885PDE4C 575/4885
US-12618859-B2 Methods and systems for automated syringe quality evaluation EIF2A, EIF3D, SRPRA PDE4A 2124/4885PDE4B 2889/4885PDE4C 2235/4885
US-20260144935-A1 DRIVE ASSEMBLY FOR A DRUG DELIVERY DEVICE AND RELATED METHODS CRH, PDE1C, DYNLL2 PDE4A 728/4885PDE4B 836/4885PDE4C 648/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.