Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.40 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.38 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.35 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.35 |
| ▸ | HTR3E known ✓ | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B known ✓ | O95264 | 1/20 | 0.35 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D known ✓ | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C known ✓ | Q8WXA8 | 1/20 | 0.35 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2960051 | 1.00 | ALDH1A1 (0.43) | ALDH1A1MAOAKDM4EGLAL3MBTL1 | |
| SCHEMBL7516473 | 0.97 | ALDH1A1 (0.45) | ALDH1A1MAOAKDM4EGLAL3MBTL1 | |
| SCHEMBL10090559 | 0.97 | ALDH1A1 (0.45) | ALDH1A1MAOAKDM4EGLAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL8488644 | 0.85 | ALDH1A1 (0.36) | ALDH1A1MAOAKDM4EGLAL3MBTL1 | |
| SCHEMBL16187277 | 0.85 | ALDH1A1 (0.37) | ALDH1A1MAOAKDM4EGLAL3MBTL1 | |
| SCHEMBL10122037 | 0.82 | ALDH1A1 (0.38) | ALDH1A1MAOAKDM4EGLAL3MBTL1 | |
| SCHEMBL15910559 | 0.82 | ALDH1A1 (0.38) | ALDH1A1MAOAKDM4EGLAL3MBTL1 | |
| SCHEMBL3803101 | 0.82 | ALDH1A1 (0.38) | ALDH1A1MAOAKDM4EGLAL3MBTL1 | |
| SCHEMBL19932533 | 0.82 | ALDH1A1 (0.38) | ALDH1A1MAOAKDM4EGLAL3MBTL1 | |
| SCHEMBL3803095 | 0.82 | ALDH1A1 (0.38) | ALDH1A1MAOAKDM4EGLAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118908921-A | Anionic pentamethine cyanine and preparation method and application thereof | 华中科技大学 | 2024-11-08 | — | — | CN | disclosed |
| CN-114805310-B | Fluorescent compounds containing hydroxy-substituted triazines and methods of making the same | 佰爱特有限公司 | 2024-07-26 | — | — | CN | disclosed |
| US-11981955-B2 | Polymethine compounds and their use as fluorescent labels | ILLUMINA CAMBRIDGE LIMITED (GB) | 2024-05-14 | — | — | US | disclosed |
| EP-3831825-B1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LTD (GB) | 2023-09-06 | — | — | EP | disclosed |
| US-11707537-B2 | Conformational restriction of cyanine fluorophores in far-red and near-IR range | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2023-07-25 | — | — | US | disclosed |
| US-20230167486-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2023-06-01 | — | — | US | disclosed |
| US-11530439-B2 | Polymethine compounds and their use as fluorescent labels | ILLUMINA CAMBRIDGE LIMITED (GB) | 2022-12-20 | — | — | US | disclosed |
| EP-4058190-A1 | COMPOSITIONS AND METHODS FOR CONTROLLED DELIVERY AND PROTECTION OF THERAPEUTIC AGENTS | Board of Regents, The University of Texas System (US) | 2022-09-21 | — | — | EP | disclosed |
| US-20210198724-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2021-07-01 | — | — | US | disclosed |
| EP-3831825-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | Illumina Cambridge Limited (GB) | 2021-06-09 | — | — | EP | disclosed |
| US-20090017441-A1 | Reacting unsubstituted or substituted 2-methylbenzothiazole, 2-methylbenzooxazole or 2,3,3-trimethyl-3H-indoline with substituted or unsubstituted benzylhalide, forming 4-methylquinoline quaternary ammonium salt intermediates, condensing with N,N'-diphenylformamidine; for staining nucleic acids | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2009-01-15 | — | — | US | disclosed |
| WO-2008127768-A1 | A CYANINE-BASED PROBE\\TAG-PEPTIDE PAIR FOR FLUORESCENCE PROTEIN IMAGING AND FLUORESCENCE PROTEIN IMAGING METHODS | BATTELLE MEMORIAL INSTITUTE (US) | 2008-10-23 | — | — | WO | disclosed |
| US-20080254546-A1 | A Cyanine-based probe\\tag-peptide pair for fluorescence protein imaging and fluorescence protein imaging methods | BATTELLE MEMORIAL INSTITUTE | 2008-10-16 | — | — | US | disclosed |
| EP-1196398-A4 | BRIDGED FLUORESCENT DYES, THEIR PREPARATION AND THEIR USE IN ASSAYS | SURROMED INC (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6403807-B1 | CYANINE DYES HAVING SEPARATE SECOND LINKING CHAIN JOINING TWO HETEROCYCLES TO RESTRAIN COMPOUND INTO DESIRED CONFORMATION WHICH ABSORBS ELECTROMAGNETIC ENERGY AND EMITS FLUORESCENCE AT SPECIFIED WAVELENGTHS | SURROMED, INC. | 2002-06-11 | — | — | US | disclosed |
| EP-1196398-A1 | BRIDGED FLUORESCENT DYES, THEIR PREPARATION AND THEIR USE IN ASSAYS | Surromed, Inc. (US) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001002374-A1 | BRIDGED FLUORESCENT DYES, THEIR PREPARATION AND THEIR USE IN ASSAYS | SURROMED, INC. (US) | 2001-01-11 | — | — | WO | disclosed |
| EP-0241696-B1 | NAPHTHOLACTAM DYES AND OPTICAL RECORDING CARRIER CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1993-07-14 | — | — | EP | disclosed |
| US-4939012-A | Semiconductor laser sensitive | BASF AKTIENGESELLSCHAFT (DE) | 1990-07-03 | — | — | US | disclosed |
| US-4876356-A | LASER SENSITIVE | BASF AKTIENGESELLSCHAFT (DE) | 1989-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11981955-B2 | Polymethine compounds and their use as fluorescent labels | POLRMT, FBL, POLM | MAOA 1580/4885GLA 2390/4885PTGS1 3106/4885 |
| US-20210198724-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | POLRMT, FBL, POLM | MAOA 1580/4885GLA 2390/4885PTGS1 3106/4885 |
| US-20230167486-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | POLRMT, FBL, POLM | MAOA 1580/4885GLA 2390/4885PTGS1 3106/4885 |
| US-11530439-B2 | Polymethine compounds and their use as fluorescent labels | POLRMT, FBL, POLM | MAOA 1580/4885GLA 2390/4885PTGS1 3106/4885 |
| US-20090017441-A1 | Reacting unsubstituted or substituted 2-methylbenzothiazole, 2-methylbenzooxazole or 2,3,3-trimethyl-3H-indoline with substituted or unsubstituted benzylhalide, forming 4-methylquinoline quaternary ammonium salt intermediates, condensing with N,N'-diphenylformamidine; for staining nucleic acids | RCC1, DNMT3A, H1-4 | MAOA 3409/4885GLA 4002/4885PTGS1 4639/4885 |
| US-20080254546-A1 | A Cyanine-based probe\\tag-peptide pair for fluorescence protein imaging and fluorescence protein imaging methods | AS3MT, EBPL, GLI2 | MAOA 4307/4885GLA 679/4885PTGS1 4808/4885 |
| US-11707537-B2 | Conformational restriction of cyanine fluorophores in far-red and near-IR range | IK, FAR1, SPR | MAOA 3261/4885GLA 723/4885PTGS1 4592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.