Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.71 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.71 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.71 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.71 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.71 |
| ▸ | CACNA1B known ✓ | Q00975 | 2/20 | 0.57 |
| ▸ | CACNA1C known ✓ | Q13936 | 8/20 | 0.55 |
| ▸ | CACNA1F known ✓ | O60840 | 7/20 | 0.55 |
| ▸ | CACNA1D known ✓ | Q01668 | 7/20 | 0.55 |
| ▸ | CACNA1S known ✓ | Q13698 | 7/20 | 0.55 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.55 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.55 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.55 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.55 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.55 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.55 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.55 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.55 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.55 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8862902 | 0.95 | ADORA3 (0.80) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| Hydrochloric Acid SCHEMBL8862900 | 0.95 | ADORA3 (0.80) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL8862887 | 0.94 | ADORA3 (0.81) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL8862889 | 0.94 | ADORA3 (0.81) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL7590320 | 0.88 | ADORA3 (0.90) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL5275957 | 0.88 | ADORA3 (0.90) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL10409943 | 0.87 | CACNA1C (0.69) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL10409941 | 0.87 | CACNA1C (0.69) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL10411083 | 0.86 | ADORA3 (0.66) | ADORA3ADRA1AMTORRAB9ASLC6A3 | |
| SCHEMBL10411081 | 0.86 | ADORA3 (0.66) | ADORA3ADRA1AMTORRAB9ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940790-B1 | POLYMORPHIC FORM OF LERCANIDIPINE HYDROCHLORIDE AND PROCESS FOR THE PREPARATION THEREOF | GLENMARK PHARMACEUTICALS LTD (IN) | 2015-09-02 | — | — | EP | disclosed |
| US-8097729-B2 | Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof | GLENMARK GENERICS LTD. (IN) | 2012-01-17 | — | — | US | disclosed |
| US-20110040097-A1 | PROCESS FOR PREPARING LERCANIDIPINE HYDROCHLORIDE | DONGWOO SYNTECH CO., LTD (KR) | 2011-02-17 | — | — | US | disclosed |
| US-20090221833-A1 | Polymorphic Form of Lercanidipine Hydrochloride and Process for the Preparation Thereof | ALIVUS LIFE SCIENCES LIMITED (IN) | 2009-09-03 | — | — | US | disclosed |
| EP-1940790-A2 | POLYMORPHIC FORM OF LERCANIDIPINE HYDROCHLORIDE AND PROCESS FOR THE PREPARATION THEREOF | Glenmark Pharmaceuticals Limited (IN) | 2008-07-09 | — | — | EP | disclosed |
| CN-101068546-A | Pharmaceutical composition, process for producing the same, and method for stabilizing dihydropyridine compound in pharmaceutical composition | EISAI R&D MAN CO LTD (JP) | 2007-11-07 | — | — | CN | disclosed |
| WO-2007031865-A2 | POLYMORPHIC FORM OF LERCANIDIPINE HYDROCHLORIDE AND PROCESS FOR THE PREPARATION THEREOF | GLENMARK PHARMACEUTICALS LIMITED (US) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221833-A1 | Polymorphic Form of Lercanidipine Hydrochloride and Process for the Preparation Thereof | ADH1C, ADH5, CYP3A4 | ADRA1A 49/4885SLC6A3 216/4885HRH1 241/4885 |
| US-20110040097-A1 | PROCESS FOR PREPARING LERCANIDIPINE HYDROCHLORIDE | REN, DNPEP, PNKP | ADRA1A 95/4885SLC6A3 1348/4885HRH1 645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.