Toluene

Toluene

SCHEMBL434566

CCN(CC)CC.Cc1ccccc1

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.61
LMNA P02545 1/20 0.61
ALOX12 P18054 1/20 0.61
ACHE P22303 1/20 0.61
KCNH2 Q12809 3/20 0.46
CHRM2 P08172 1/20 0.46
HTR1A P08908 1/20 0.46
ADRA2A P08913 1/20 0.46
CHRM1 P11229 1/20 0.46
DRD1 P21728 1/20 0.46
SLC6A2 P23975 1/20 0.46
SLC6A4 P31645 1/20 0.46
ADRA1A P35348 1/20 0.46
OPRM1 P35372 1/20 0.46
DRD3 P35462 1/20 0.46
SLC6A3 Q01959 1/20 0.46
SIGMAR1 Q99720 2/20 0.43
CYP2C19 P33261 1/20 0.41
KDM4E B2RXH2 2/20 0.39
MAPT P10636 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toluene SCHEMBL4266725 0.97 TSHR (0.58) TSHRLMNAALOX12ACHEKCNH2
Toluene SCHEMBL28280046 0.97 TSHR (0.58) TSHRLMNAALOX12ACHEKCNH2
Toluene SCHEMBL3278606 0.97 LMNA (0.58) TSHRLMNAALOX12ACHEKCNH2
Toluene SCHEMBL5725705 0.95 TSHR (0.55) TSHRLMNAALOX12ACHEKCNH2
Toluene SCHEMBL6659437 0.93 LMNA (0.52) TSHRLMNAALOX12ACHEKCNH2
Toluene SCHEMBL11302102 0.91 LMNA (0.50) TSHRLMNAALOX12ACHEKCNH2
Toluene SCHEMBL2152594 0.91 KCNH2 (0.52) TSHRLMNAALOX12ACHEKCNH2
Toluene SCHEMBL28533776 0.91 ACHE (0.50) TSHRLMNAALOX12ACHEKCNH2
Toluene SCHEMBL15192049 0.89 TSHR (0.48) TSHRLMNAALOX12ACHEKCNH2
Heptane SCHEMBL6470761 0.89 KCNH2 (0.55) TSHRLMNAALOX12ACHEKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 213 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115286624-A Preparation method of thiamethoxam 内蒙古犇星化学有限公司 2022-11-04 CN claimed
CN-114621099-A Preparation method of quaternary ammonium salt ionic liquid corrosion inhibitor 辽宁科技学院 2022-06-14 CN claimed
US-20210060106-A1 METHOD FOR OBTAINING SAPONINS FROM PLANTS DESERT KING CHILE S.A. (CL) 2021-03-04 US claimed
CN-109092338-B Preparation method and application of vanadyl phosphate catalyst 中国科学院过程工程研究所 2020-07-28 CN claimed
CN-106831416-B A kind of preparation method of high-content TrinexAN_SNacethyl raw medicine 淮安国瑞化工有限公司 2019-11-08 CN claimed
CN-109553571-A The method of chloro--methylpyridine is continuously prepared in a kind of microchannel 内蒙古元正精细化工有限责任公司 2019-04-02 CN claimed
CN-107337665-A A kind of synthetic method with triazole ring structure immunosuppressive drug 淄博职业学院 2017-11-10 CN claimed
CN-102936263-A Novel synthetic phospholipid and application thereof LIYANG ADVANCED VEHICLE TECHNOLOGY CO LTD 2013-02-20 CN claimed
CN-101362779-B Synthesis method of octaphenyltetrasiloxanyl cyclic ether UNIV HEFEI TECHNOLOGY 2011-03-16 CN claimed
CN-101362779-A Synthesis method of octaphenyltetrasiloxanyl cyclic ether UNIV HEFEI TECHNOLOGY (CN) 2009-02-11 CN claimed
CN-1301240-C Preparation and use of fluorescent marking reagent 2-naphthoxy acetyl chloride NUCLEAR MEDICAL INST JIANGSU (CN) 2007-02-21 CN claimed
CN-1645144-A Preparation and use of fluorescent marking reagent 2-naphthoxy acetyl chloride NUCLEAR MEDICAL INST JIANGSU (CN) 2005-07-27 CN claimed
US-20040249099-A1 Acrylic esters of 2-cyano-2, 4 pentenedioic acid CHEMENCE, INC. 2004-12-09 US claimed
EP-0362309-B1 (ETHYLENEDIOXO-3,3 CYCLOHEXYL)-4 ACETOPHENONE AND DERIVATIVES THEREOF, PROCESSES FOR PREPARING THEM AND USE OF THESE COMPOUNDS SOCHINAZ, SOCIETE CHIMIQUE DE VIONNAZ S.A. (CH) 1992-09-23 EP claimed
WO-1992009651-A1 POLYCYANOACRYLATE FOAM CHEMENCE LIMITED (GB) 1992-06-11 WO claimed
US-5104995-A Multistage reactions for preparing 2-(4-(3-oxocyclohexyl) phenyl) propionic acid SOCHINAZ, SOCIETE CHIMIQUE DE VIOMAZ S.A. (CH) 1992-04-14 US claimed
EP-0362309-A1 (ETHYLENEDIOXO-3,3 CYCLOHEXYL)-4 ACETOPHENONE AND DERIVATIVES THEREOF, PROCESSES FOR PREPARING THEM AND USE OF THESE COMPOUNDS. SOCHINAZ SOCIETE CHIMMIQUE DE (CH) 1990-04-11 EP claimed
WO-1989009215-A1 (ETHYLENEDIOXO-3,3 CYCLOHEXYL)-4 ACETOPHENONE AND DERIVATIVES THEREOF, PROCESSES FOR PREPARING THEM AND USE OF THESE COMPOUNDS SOCHINAZ, SOCIETE CHIMIQUE DE VIONNAZ S.A. (CH) 1989-10-05 WO claimed
US-4374291-A Synthesis of bis(ethynylphenyl) compounds HUGHES AIRCRAFT COMPANY (US) 1983-02-15 US claimed
CN-115710217-B Flunixin meglumine synthesis method suitable for industrial production 江苏恒盛药业有限公司 2025-06-13 CN disclosed
CN-110875348-B Display apparatus 三星显示有限公司 2025-02-07 CN disclosed
CN-118255748-A Method for recycling and applying tetrazole reaction solvent 浙江华海药业股份有限公司 2024-06-28 CN disclosed
US-11912659-B2 EBNA1 inhibitors and methods using same THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2024-02-27 US disclosed
EP-4273624-A1 NEGATIVE PHOTOSENSITIVE RESIN COMPOSITION, PATTERNING PROCESS, INTERLAYER INSULATING FILM, SURFACE PROTECTION FILM, AND ELECTRONIC COMPONENT SHIN-ETSU CHEMICAL CO., LTD. (JP) 2023-11-08 EP disclosed
EP-3717494-B1 HIGHLY ISOSELECTIVE CATALYST FOR ALKENE HYDROFORMYLATION EASTMAN CHEM CO (US) 2023-11-01 EP disclosed
CN-116715586-A Recovery method of acid binding agent triethylamine in preparation process of 5-nonylsalicylaldehyde 福建紫金选矿药剂有限公司 2023-09-08 CN disclosed
CN-108341960-B Dynamic polymer containing combined dynamic covalent bonds and application thereof 厦门天策材料科技有限公司 2023-08-25 CN disclosed
CN-108341961-B Preparation and application of dynamic polymer containing combined dynamic covalent bonds 厦门天策材料科技有限公司 2023-08-25 CN disclosed
US-11672758-B2 Endoxifen methods and compositions for inhibition of protein kinase C JINA PHARMACEUTICALS, INC. (US) 2023-06-13 US disclosed
CN-115894873-A Polymer with HLCT (high-intensity-scanning-Current computed tomography) property, preparation method and application thereof, organic light-emitting diode and display panel 中国科学院宁波材料技术与工程研究所 2023-04-04 CN disclosed
CN-115286624-A Preparation method of thiamethoxam 内蒙古犇星化学有限公司 2022-11-04 CN disclosed
CN-114621099-A Preparation method of quaternary ammonium salt ionic liquid corrosion inhibitor 辽宁科技学院 2022-06-14 CN disclosed
US-20220115567-A1 DISPLAY DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2022-04-14 US disclosed
US-11227980-B2 Display device SAMSUNG DISPLAY CO., LTD. (KR) 2022-01-18 US disclosed
CN-113149885-A EBNA1 inhibitors and methods of using the same 威斯塔解剖学和生物学研究所 2021-07-23 CN disclosed
EP-3294705-B1 EBNA1 INHIBITORS AND METHODS USING SAME WISTAR INST (US) 2021-07-21 EP disclosed
US-20210177752-A1 ENDOXIFEN METHODS AND COMPOSITIONS FOR INHIBITION OF PROTEIN KINASE C JINA PHARMACEUTICALS, INC. 2021-06-17 US disclosed
US-10981867-B2 EBNA1 inhibitors and methods using same THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2021-04-20 US disclosed
CN-109721567-B Catalyst and method for preparing glycidyl methacrylate by catalysis 万华化学集团股份有限公司 2021-02-02 CN disclosed
EP-3717494-A1 HIGHLY ISOSELECTIVE CATALYST FOR ALKENE HYDROFORMYLATION Eastman Chemical Company (US) 2020-10-07 EP disclosed
EP-3717120-A1 HIGHLY ISOSELECTIVE CATALYST FOR ALKENE HYDROFORMYLATION Eastman Chemical Company (US) 2020-10-07 EP disclosed
US-20200239415-A1 EBNA1 INHIBITORS AND METHODS USING SAME WISTAR INST (US) 2020-07-30 US disclosed
CN-110875348-A Display device 三星显示有限公司 2020-03-10 CN disclosed
US-20200075814-A1 DISPLAY DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2020-03-05 US disclosed
CN-110431203-A Organosilicon, composition through ion modification and the medical equipment formed by it MOMENTIVE PERFORMANCE MAT INC 2019-11-08 CN disclosed
CN-110418796-A The glucosiduronate prodrug of tropsch imatinib (TOFACITINIB) THERAVANCE BIOPHARMA R&D IP LLC 2019-11-05 CN disclosed
US-10442763-B2 EBNA1 inhibitors and methods using same THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2019-10-15 US disclosed
CN-107290453-B The HPLC analysis method of palonosetron Hcl synthesis intermediate product 方达医药技术(上海)有限公司 2019-09-17 CN disclosed
US-10376479-B2 Endoxifen compositions and methods JINA PHARMACEUTICALS, INC. (US) 2019-08-13 US disclosed
US-20190231687-A1 ENDOXIFEN METHODS AND COMPOSITIONS IN THE TREATMENT OF PSYCHIATRIC AND NEURODEGENERATIVE DISEASES JINA PHARMACEUTICALS, INC. 2019-08-01 US disclosed
US-10351583-B2 Highly isoselective catalyst for alkene hydroformylation EASTMAN CHEMICAL COMPANY (US) 2019-07-16 US disclosed
CN-109935553-A Packaging plastic and encapsulating structure TCL集团股份有限公司 2019-06-25 CN disclosed
US-20190161508-A1 HIGHLY ISOSELECTIVE CATALYST FOR ALKENE HYDROFORMYLATION EASTMAN CHEMICAL COMPANY (US) 2019-05-30 US disclosed
CN-109311890-A BET protein degradation agent 密执安大学评议会 2019-02-05 CN disclosed
US-10183961-B1 Highly isoselective catalyst for alkene hydroformylation EASTMAN CHEMICAL COMPANY (US) 2019-01-22 US disclosed
US-10144751-B1 Highly isoselective catalyst for alkene hydroformylation EASTMAN CHEMICAL COMPANY (US) 2018-12-04 US disclosed
US-20180305312-A1 EBNA1 INHIBITORS AND METHODS USING SAME NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-10-25 US disclosed
CN-104884059-B Mixing pedigree kinase inhibitor for HIV/AIDS treatments 罗切斯特大学 2018-08-10 CN disclosed
CN-108341960-A It is a kind of to contain the dynamic aggregation object for combining dynamic covalent bond and its application 翁秋梅 2018-07-31 CN disclosed
CN-108341961-A A kind of preparation of dynamic aggregation object and its application containing combination dynamic covalent bond 翁秋梅 2018-07-31 CN disclosed
CN-105601976-B Method for preparing antibacterial surface on surface of biomedical material 苏州大学 2018-07-03 CN disclosed
EP-3294705-A1 EBNA1 INHIBITORS AND METHODS USING SAME The Wistar Institute Of Anatomy And Biology (US) 2018-03-21 EP disclosed
EP-3105239-B1 METHOD FOR REDUCING THE CHLORINE CONTENT OF ORGANOBISPHOSPHITES EVONIK DEGUSSA GMBH (DE) 2018-03-14 EP disclosed
EP-2101731-B1 ENDOXIFEN FOR USE IN THE TREATMENT OF CANCER JINA PHARMACEUTICALS INC (US) 2018-01-31 EP disclosed
CN-107383087-A For preparing the high selective method of organodiphosphite 英威达纺织(英国)有限公司 2017-11-24 CN disclosed
CN-107382989-A A kind of synthetic method with oxazole ring structure immunosuppressive drug 河南科技大学第附属医院 2017-11-24 CN disclosed
CN-107311994-A A kind of novel method for synthesizing of the receptor stimulating agent drug molecules of S1P 1 淄博职业学院 2017-11-03 CN disclosed
CN-104159616-B Chewing gum for diagnosing inflammatory tissue in dental applications 托门医学股份公司 2017-10-31 CN disclosed
CN-107298677-A The preparation method and application of evil azole compounds with immunosuppressive activity 侯茜茜 2017-10-27 CN disclosed
CN-107290453-A The HPLC analysis methods of palonosetron Hcl synthetic mesophase product 南京普氟生物检测技术有限公司 2017-10-24 CN disclosed
CN-105289532-B A kind of vitamin B12 molecular engram solid phase extraction magnetic material and its preparation method and application 华南理工大学 2017-10-20 CN disclosed
WO-2017108972-A1 COMPOUNDS OF R-(-)-(E)-[4-(2,4-DICHLOROPHENYL)-1,3-DITHIOLAN-2-YLIDENE]-1 -IMIDAZOLYLACETONITRILE-HA (LULICONAZOLE-HA) AS ANTIFUNGALS LABORATORIOS LESVI, S.L. (ES) 2017-06-29 WO disclosed
EP-3105239-A1 METHOD FOR REDUCING THE CHLORINE CONTENT OF ORGANOBISPHOSPHITES Evonik Degussa GmbH (DE) 2016-12-21 EP disclosed
US-20160346230-A1 Endoxifen Compositions And Methods JINA PHARMACEUTICALS, INC. 2016-12-01 US disclosed
WO-2016183534-A1 EBNA1 INHIBITORS AND METHODS USING SAME THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY (US) 2016-11-17 WO disclosed
CN-105924645-A Halogen-free expanding flame retardant containing polymeric macromolecule triazine rings and preparation method of halogen-free expanding flame retardant 南京林业大学 2016-09-07 CN disclosed
CN-105732703-A HIGHLY SELECTIVE PROCESS FOR PRODUCING ORGANODIPHOSPHITES 因温斯特技术公司 2016-07-06 CN disclosed
US-9333190-B2 Endoxifen compositions and methods JINA PHARMACEUTICALS, INC. (US) 2016-05-10 US disclosed
CN-104292141-B Macromole hindered phenol antioxygen of Sulfide-containing Hindered and carbamate groups and preparation method thereof and application SOUTH CHINA UNIVERSITY OF TECHNOLOGY (CN) 2016-03-02 CN disclosed
CN-105289532-A Molecularly-imprinted solid-phase extraction magnetic material for vitamin B12 and preparation method and application thereof UNIV SOUTH CHINA TECH 2016-02-03 CN disclosed
CN-105175750-A Preparation method of aquagel microspheres UNIV HENAN TECHNOLOGY 2015-12-23 CN disclosed
CN-101365501-B Hydrophilic coatings comprising polyelectrolytes DSM IP ASSETS B.V. (NL) 2015-12-16 CN disclosed
CN-102936263-B Synthetic phospholipid that one class is novel and uses thereof A.V.T.(LIYANG) MEDICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) 2015-11-25 CN disclosed
CN-104955803-A Preparation of 3-amino-piperidine compounds via nitro-tetrahydropyridine precursors LEK PHARMACEUTICALSD D 2015-09-30 CN disclosed
WO-2015121007-A1 METHOD FOR REDUCING THE CHLORINE CONTENT OF ORGANOBISPHOSPHITES EVONIK DEGUSSA GMBH (DE) 2015-08-20 WO disclosed
CN-104804203-A Preparation method of hydrogel microspheres UNIV HENAN TECHNOLOGY 2015-07-29 CN disclosed
CN-101622020-B Hydrophilic coating DSM IP ASSETS BV 2015-07-01 CN disclosed
CN-102964378-B Preparation of phosphatidylethanolamine A V T LIYANG MEDICAL SCIENCE & TECHNOLOGY CO LTD 2015-05-20 CN disclosed
EP-2149560-B1 1-SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND ASTELLAS PHARMA INC (JP) 2015-05-13 EP disclosed
CN-104292141-A Macromolecular hindered phenol antioxidant containing thioether and carbamate groups and preparation method and application thereof UNIV SOUTH CHINA TECH 2015-01-21 CN disclosed
WO-2015000935-A1 FLUORINATION PROCESS SOLVAY SA (BE) 2015-01-08 WO disclosed
CN-101622019-B Hydrophilic coating DSM IP ASSETS BV 2015-01-07 CN disclosed
EP-2821388-A1 Fluorination process Solvay SA (BE) 2015-01-07 EP disclosed
CN-103642033-A Guerbet alcohol nonionic surfactant UNIV NANJING SCIENCE & TECH 2014-03-19 CN disclosed
US-8557982-B2 Tubulin polymerisation inhibitors BIONOMICS LIMITED (AU) 2013-10-15 US disclosed
EP-2573833-A1 Organic semiconductors, their manufacture and semiconductor devices comprising them BASF SE (DE) 2013-03-27 EP disclosed
CN-102964378-A Preparation of phosphatidylethanolamine A V T LIYANG MEDICAL SCIENCE & TECHNOLOGY CO LTD 2013-03-13 CN disclosed
CN-102936263-A Novel synthetic phospholipid and application thereof LIYANG ADVANCED VEHICLE TECHNOLOGY CO LTD 2013-02-20 CN disclosed
US-8344007-B2 Water-soluble polymer-based cantharimides as potentially selective anti-tumor agents THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2013-01-01 US disclosed
US-20120309768-A1 NOVEL TUBULIN POLYMERISATION INHIBITORS BIONOMICS LIMITED (AU) 2012-12-06 US disclosed
CN-101945898-B Catalyst component for ethylene polymerization and process for producing ethylene polymer (2) SUMITOMO CO LTD 2012-10-10 CN disclosed
US-8278290-B2 Tubulin polymerisation inhibitors Biononics Limited (AU) 2012-10-02 US disclosed
US-8263607-B2 1-substituted tetrahydroisoquinoline compound ASTELLAS PHARMA INC. (JP) 2012-09-11 US disclosed
CN-101855251-B Triethylamine functionalized elastomers for barrier applications EXXON MOBIL CHEM PATENTS INC 2012-09-05 CN disclosed
US-20120164075-A1 ENDOXIFEN METHODS AND COMPOSITIONS IN THE TREATMENT OF MAMMALIAN DISEASES JINA PHARMACEUTICALS, INC. (US) 2012-06-28 US disclosed
CN-102405226-A Highly selective process for the preparation of organodiphosphites INVISTA TECH SARL 2012-04-04 CN disclosed
CN-102405225-A Highly selective process for the preparation of organodiphosphites INVISTA TECH SARL 2012-04-04 CN disclosed
EP-2432462-A2 ENDOXIFEN METHODS AND COMPOSITIONS IN THE TREATMENT OF MAMMALIAN DISEASES Jina Pharmaceuticals Inc. (US) 2012-03-28 EP disclosed
US-8101776-B2 Organic semiconductors and their manufacture BASF SE (DE) 2012-01-24 US disclosed
EP-2363390-A1 DERIVED LACTAM FROM D3 VITAMIN Teijin Pharma Limited (JP) 2011-09-07 EP disclosed
US-20110207944-A1 VITAMIN D3 LACTAM DERIVATIVE TEIJIN PHARMA LIMITED (JP) 2011-08-25 US disclosed
US-7910579-B2 Benzoxazole derivatives TOHOKU UNIVERSITY (JP) 2011-03-22 US disclosed
CN-101970583-A Hydrophilic coating DSM IP ASSETS BV 2011-02-09 CN disclosed
CN-101945898-A Catalyst component for ethylene polymerization and process for producing ethylene polymer (2) SUMITOMO CHEMICAL CO 2011-01-12 CN disclosed
WO-2010135703-A2 ENDOXIFEN METHODS AND COMPOSITIONS IN THE TREATMENT OF MAMMALIAN DISEASES JINA PHARMACEUTICALS, INC. (US) 2010-11-25 WO disclosed
US-20100292190-A1 NOVEL TUBULIN POLYMERISATION INHIBITORS BIONOMICS LIMITED (AU) 2010-11-18 US disclosed
US-20100273840-A1 WATER-SOLUBLE POLYMER-BASED CANTHARIMIDES AS POTENTIALLY SELECTIVE ANTI-TUMOR AGENTS THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2010-10-28 US disclosed
CN-101855251-A Triethylamine functionalized elastomers for barrier applications EXXONMOBIL CHEM PATENTS INC 2010-10-06 CN disclosed
WO-2010100413-A2 CROSS-LINKABLE POLYMERS OXFORD ADVANCED SURFACES LTD (GB) 2010-09-10 WO disclosed
CN-101784540-A alcohols containing imide moieties and reactive oligomers prepared therefrom NAT STARCH CHEM INVEST 2010-07-21 CN disclosed
US-20100168154-A1 1-SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND ASTELLAS PHARMA INC. (JP) 2010-07-01 US disclosed
CN-1990528-B Method for functionalization on magnetic nano particle surface CHENGDU ORGANIC CHEMICALS CO 2010-06-16 CN disclosed
US-20100112041-A1 Endoxifen Compositions And Methods JINA PHARMACEUTICALS, INC. (US) 2010-05-06 US disclosed
EP-2149560-A1 1-SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND Astellas Pharma Inc. (JP) 2010-02-03 EP disclosed
US-20100021385-A1 BENZOXAZOLE DERIVATIVES TOHOKU UNIVERSITY (JP) 2010-01-28 US disclosed
CN-101622019-A Hydrophilic coating DSM IP ASSETS BV 2010-01-06 CN disclosed
US-20090299070-A1 Organic Semiconductors and Their Manufacture CLAP CO., LTD. (KR) 2009-12-03 US disclosed
US-20090291134-A1 ENDOXIFEN METHODS AND COMPOSITIONS IN THE TREATMENT OF PSYCHIATRIC AND NEURODEGENERATIVE DISEASES JINA PHARMACEUTICALS, INC. (US) 2009-11-26 US disclosed
EP-2103611-A1 BENZOXAZOLE DERIVATIVES Tohoku University (JP) 2009-09-23 EP disclosed
EP-2101731-A2 ENDOXIFEN METHODS AND COMPOSITIONS Jina Pharmaceuticals Inc. (US) 2009-09-23 EP disclosed
WO-2009083724-A1 PROCESSES FOR THE PREPARATION OF THALIDOMIDE CIPLA LIMITED (IN) 2009-07-09 WO disclosed
US-7504530-B2 Methods for the preparation of fispemifene from ospemifene HORMOS MEDICAL LTD. (FI) 2009-03-17 US disclosed
CN-101365501-A Hydrophilic coatings comprising polyelectrolytes DSM IP ASSETS BV (NL) 2009-02-11 CN disclosed
WO-2008070463-A9 ENDOXIFEN METHODS AND COMPOSITIONS JINA PHARMACEUTICALS INC (US) 2008-09-18 WO disclosed
US-20080214860-A1 METHODS FOR THE PREPARATION OF FISPEMIFENE FROM OSPEMIFENE QUATRX PHARMACEUTICALS COMPANY 2008-09-04 US disclosed
EP-1961052-A1 ORGANIC SEMICONDUCTORS AND THEIR MANUFACTURE Ciba Specialty Chemicals Holding Inc. (CH) 2008-08-27 EP disclosed
WO-2008070463-A2 ENDOXIFEN METHODS AND COMPOSITIONS JINA PHARMACEUTICALS, INC. (US) 2008-06-12 WO disclosed
CN-101137636-A Exo-selective synthesis of himbacine analogs SCHERING CORP (US) 2008-03-05 CN disclosed
EP-1848704-A1 NOVEL TUBULIN POLYMERISATION INHIBITORS Bionomics Limited (AU) 2007-10-31 EP disclosed
CN-1990528-A Method for functionalization on magnetic nano particle surface CHENGDU ORGANIC CHEMICALS CO (CN) 2007-07-04 CN disclosed
WO-2007068618-A1 ORGANIC SEMICONDUCTORS AND THEIR MANUFACTURE CIBA HOLDING INC. (CH) 2007-06-21 WO disclosed
CN-1968922-A Factor XA inhibitors MILLENNIUM PHARM INC (US) 2007-05-23 CN disclosed
CN-1301240-C Preparation and use of fluorescent marking reagent 2-naphthoxy acetyl chloride NUCLEAR MEDICAL INST JIANGSU (CN) 2007-02-21 CN disclosed
US-7125942-B2 Acrylic esters of 2-cyano-2, 4 pentenedioic acid CLAST TRADING LTD (HK) 2006-10-24 US disclosed
EP-1705169-A2 Triphenylalkene derivatives and their use as selective estrogen receptor modulators Hormos Medical Ltd. (FI) 2006-09-27 EP disclosed
WO-2006084338-A1 NOVEL TUBULIN POLYMERISATION INHIBITORS BIONOMICS LIMITED (AU) 2006-08-17 WO disclosed
EP-1054887-B1 BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS AMGEN INC (US) 2006-04-12 EP disclosed
CN-1249054-C Process for preparation of aripiprazole CHONGQING PHARM RES INST CO (CN) 2006-04-05 CN disclosed
EP-1235776-B1 TRIPHENYLALKENE DERIVATIVES AND THEIR USE AS SELECTIVE ESTROGEN RECEPTOR MODULATORS HORMOS MEDICAL CORP (FI) 2006-02-08 EP disclosed
CN-1235880-C Quinolinenone kind derivative and its accetable salt, its preparation method, application in preparation of alipyrazole and preparation of alipyrazole CHONGQING MEDICINE INDUSTRY IN (CN) 2006-01-11 CN disclosed
CN-1649849-A Tachykinin receptor antagonists LILLY CO ELI (US) 2005-08-03 CN disclosed
CN-1645144-A Preparation and use of fluorescent marking reagent 2-naphthoxy acetyl chloride NUCLEAR MEDICAL INST JIANGSU (CN) 2005-07-27 CN disclosed
US-6875775-B2 Triphenylalkene derivatives and their use as selective estrogen receptor modulators HORMOS MEDICAL OY LTD (FI) 2005-04-05 US disclosed
CN-1576273-A Process for Producing Aliprazo CHONGQING MEDICAL INDUSTRY RES (CN) 2005-02-09 CN disclosed
CN-1569845-A Process for preparation of aripiprazole CHONGQING PHARM RES INST CO (CN) 2005-01-26 CN disclosed
EP-1487848-A2 A BUILDING BLOCK FORMING A C=C DOUBLE BOND UPON REACTION Nuevolution A/S (DK) 2004-12-22 EP disclosed
US-20040249099-A1 Acrylic esters of 2-cyano-2, 4 pentenedioic acid CHEMENCE, INC. 2004-12-09 US disclosed
CN-1513841-A Quinolinenone kind derivative and its accetable salt, its preparation method, application in preparation of alipyrazole and preparation of alipyrazole 重庆医药工业研究院有限责任公司 2004-07-21 CN disclosed
US-6765092-B2 OXIDIZING A CHLORIN TO PRODUCE A MIXTURE OF HYDROXYCHLORIN AND OXOCHLORIN, AND THEN OXIDIZING THE HYDROXYCHLORIN, PREFERABLY WITH DDQ NORTH CAROLINA STATE UNIVERSITY 2004-07-20 US disclosed
CN-1507436-A Aryl and heteroaryl urea CHK1 inhibitors for use as radiosensitizers and chamosensitizers 2004-06-23 CN disclosed
US-20030225130-A1 Triphenylalkene derivatives and their use as selective estrogen receptor modulators HORMOS MEDICAL OY LTD. 2003-12-04 US disclosed
WO-2003078445-A2 A BUILDING BLOCK FORMING A C=C DOUBLE BOND UPON REACTION NUEVOLUTION A/S (DK) 2003-09-25 WO disclosed
US-6583154-B1 Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines AMGEN INC. 2003-06-24 US disclosed
US-6576645-B1 Such as 3-(4-chloro-1-(4-(2-(2-hydroxyethoxy)ethoxy)phenyl)--2-phenylbut-1 -enyl)phenol; producing tissue specific estro-genic and/or antiestrogenic effect HORMOS MEDICAL OY LTD (FI) 2003-06-10 US disclosed
US-20020137925-A1 Regioisomerically pure oxochlorins and methods of synthesis NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2002-09-26 US disclosed
EP-1235776-A1 TRIPHENYLALKENE DERIVATIVES AND THEIR USE AS SELECTIVE ESTROGEN RECEPTOR MODULATORS Hormos Medical Corporation (FI) 2002-09-04 EP disclosed
US-6426395-B1 SUCH AS OXO-BIS-(DIMETHYLSILYLENE-BIS(2,3,5-TRIMETHYLCYCLOPENTADIENYL)ZIRCONIUM CHLORIDE); CRYSTALLIZATION/ CRYSTAL STRUCTURE CHISSO CORPORATION (JP) 2002-07-30 US disclosed
CN-1355697-A IL-8 receptor antagonists SMITHKLINE BEECHAM CORP (US) 2002-06-26 CN disclosed
EP-1169316-A1 NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2002-01-09 EP disclosed
CN-1066311-C Method for preparing acaricide Kemante CHENGSHI CHENGXIN COMMERCIAL T (CN) 2001-05-30 CN disclosed
WO-2001036360-A1 TRIPHENYLALKENE DERIVATIVES AND THEIR USE AS SELECTIVE ESTROGEN RECEPTOR MODULATORS HORMOS MEDICAL CORPORATION (FI) 2001-05-25 WO disclosed
US-6187777-B1 PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS AMGEN INC. 2001-02-13 US disclosed
US-6180625-B1 MODULATING AND NORMALIZING AN IMPAIRED HAEMOSTATIC BALANCE IN A MAMMAL, WHICH METHOD COMPRISES ADMINISTERING AN EFFECTIVE AMOUNT OF NOVEL BENZOXAZIN DERIVATIVES; ANTICOAGULANTS NOVO NORDISK A/S (DK) 2001-01-30 US disclosed
EP-1054887-A1 BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS Amgen Inc. (US) 2000-11-29 EP disclosed
US-6143769-A ENANTIOMORPH KARL THOMAE GMBH (DE) 2000-11-07 US disclosed
WO-2000059899-A1 NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SOCIETE DE CONSEIL DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2000-10-12 WO disclosed
CN-1048722-C (S)(+)-2-Ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]-aminocarbonylmethyl]-benzoic acid, pharmaceutical compositions containing compound and processes for preparation thereof THOMAE GMBH DR K (DE) 2000-01-26 CN disclosed
WO-1999048878-A1 HETEROCYCLIC COMPOUNDS REGULATING CLOTTING NOVO NORDISK A/S (DK) 1999-09-30 WO disclosed
WO-1999040091-A1 BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS AMGEN INC. (US) 1999-08-12 WO disclosed
CN-1041317-C Monomeric hindered amine esters of monocarboxylic resin acids and olefin polymer compositions stabilized therewith. HIMONT INC (US) 1998-12-23 CN disclosed
CN-1190532-A Method for preparing acaricide Kemante CHENGSHI CHENGXIN COMMERCIAL T (CN) 1998-08-19 CN disclosed
US-5783572-A TREATMENT OF NEURODEGENERATIVE DISORDERS PFIZER INC. (US) 1998-07-21 US disclosed
US-5594025-A Method of inhibiting gastric acid secretion with 5-substituted-3-aminochromane ELI LILLY AND COMPANY (US) 1997-01-14 US disclosed
US-5594034-A ADMINISTERING DIRECT ACTING 5-HYDROXYTRYPTAMINE AGONIST TO MAMMAL ELI LILLY AND COMPANY (US) 1997-01-14 US disclosed
EP-0455510-B1 Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion LILLY CO ELI (US) 1996-11-27 EP disclosed
US-5576352-A Method of inhibiting gastric acid secretion with aryloxypropanolamines ELI LILLY AND COMPANY (US) 1996-11-19 US disclosed
WO-1996008468-A1 CARBAMOYLOXY AMINE COMPOUNDS H. LUNDBECK A/S (DK) 1996-03-21 WO disclosed
CN-1030699-C Preparation method of trifluoropropene compound AMERICAN CYANAMID CO (US) 1996-01-17 CN disclosed
US-5457120-A Antisecretory and antiserotonine agents ELI LILLY AND COMPANY (US) 1995-10-10 US disclosed
WO-1995007278-A1 FUNGICIDAL, MITICIDAL AND ARTHROPODICIDAL AMINOPYRIMIDINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1995-03-16 WO disclosed
US-5340838-A Administering serotonin agonist to mammals ELI LILLY AND COMPANY (US) 1994-08-23 US disclosed
US-5312924-A Compounds for lowering blood sugar and effecting metabolism DR. KARL THOMAE GMBH (DE) 1994-05-17 US disclosed
US-5258379-A ADMINISTERING IN AN EFFECTIVE DOSAGE TO MAMMALS ELI LILLY AND COMPANY (US) 1993-11-02 US disclosed
US-5245060-A Reaction of terpene and iminoalkanoate, complex rhodium catalyst EISAI CO. LTD. (JP) 1993-09-14 US disclosed
CN-1072694-A Monocarboxylic acid resinous acid and with the monomeric hindered amine esters of its stable olefin polymer compositions HIMONT INC (US) 1993-06-02 CN disclosed
CN-1068820-A (S) (+)-2-oxyethyl group-4-[N-[1-(2-piperidino-phenyl)-3-methyl isophthalic acid-butyl] amino carbonyl methyl] phenylformic acid, contain pharmaceutical composition of this compound and preparation method thereof THOMAE GMBH DR K (DE) 1993-02-10 CN disclosed
US-5158956-A Administering serotonin receptor agonist ELI LILLY AND COMPANY (US) 1992-10-27 US disclosed
EP-0362309-B1 (ETHYLENEDIOXO-3,3 CYCLOHEXYL)-4 ACETOPHENONE AND DERIVATIVES THEREOF, PROCESSES FOR PREPARING THEM AND USE OF THESE COMPOUNDS SOCHINAZ, SOCIETE CHIMIQUE DE VIONNAZ S.A. (CH) 1992-09-23 EP disclosed
WO-1992009651-A1 POLYCYANOACRYLATE FOAM CHEMENCE LIMITED (GB) 1992-06-11 WO disclosed
CN-1059738-A Monocarboxylate and form with the in addition stable olefin polymer of this ester HIMONT INC (US) 1992-03-25 CN disclosed
US-5096908-A 5-HT1A agonist ELI LILLY AND COMPANY (US) 1992-03-17 US disclosed
CN-1058587-A Insecticidal acaricidal and nematicidal 2-aryl-5- (trifluoromethyl) pyrrole compounds AMERICAN CYANAMID CO (US) 1992-02-12 CN disclosed
EP-0460924-A1 Dichloroaniline compound GLAXO GROUP LIMITED (GB) 1991-12-11 EP disclosed
EP-0455510-A2 Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion ELI LILLY AND COMPANY (US) 1991-11-06 EP disclosed
EP-0362309-A1 (ETHYLENEDIOXO-3,3 CYCLOHEXYL)-4 ACETOPHENONE AND DERIVATIVES THEREOF, PROCESSES FOR PREPARING THEM AND USE OF THESE COMPOUNDS. SOCHINAZ SOCIETE CHIMMIQUE DE (CH) 1990-04-11 EP disclosed
US-4891168-A Process for producing steroid derivatives NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1990-01-02 US disclosed
WO-1989009215-A1 (ETHYLENEDIOXO-3,3 CYCLOHEXYL)-4 ACETOPHENONE AND DERIVATIVES THEREOF, PROCESSES FOR PREPARING THEM AND USE OF THESE COMPOUNDS SOCHINAZ, SOCIETE CHIMIQUE DE VIONNAZ S.A. (CH) 1989-10-05 WO disclosed
US-4814472-A Diethynylated diphenyl hexafluoropropanes HUGHES AIRCRAFT COMPANY (US) 1989-03-21 US disclosed
EP-0261656-A1 A process for producing steroid derivatives NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1988-03-30 EP disclosed
US-4508912-A UNING METAL OXIDE, HYDROXIDE, ACID OR ACID SALT, OR ORGANOBASIC COMPOUND CATALYST AJINOMOTO COMPANY, INCORPORATED (JP) 1985-04-02 US disclosed
US-4465833-A ALKYNYLATION HALOGENATED BENZENE COMPOUND IN PRESENCE OF METAL CATALYST HUGHES AIRCRAFT COMPANY (US) 1984-08-14 US disclosed
US-4374291-A Synthesis of bis(ethynylphenyl) compounds HUGHES AIRCRAFT COMPANY (US) 1983-02-15 US disclosed
EP-0050428-A1 Ethynylated aromatic compounds and process for making same Hughes Aircraft Company (US) 1982-04-28 EP disclosed
EP-0050428-A1 Ethynylated aromatic compounds and process for making same Hughes Aircraft Company (US) 1982-04-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (28 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100112041-A1 Endoxifen Compositions And Methods CYP46A1, PLA2G2F, VDR TSHR 3322/4885LMNA 1312/4885ALOX12 138/4885
US-20160346230-A1 Endoxifen Compositions And Methods CYP46A1, PLA2G2F, VDR TSHR 3322/4885LMNA 1312/4885ALOX12 138/4885
US-20200239415-A1 EBNA1 INHIBITORS AND METHODS USING SAME MLLT1, EBNA1BP2, MALT1 TSHR 4040/4885LMNA 897/4885ALOX12 1625/4885
US-20090291134-A1 ENDOXIFEN METHODS AND COMPOSITIONS IN THE TREATMENT OF PSYCHIATRIC AND NEURODEGENERATIVE DISEASES NLN, BDNF, LITAF TSHR 2821/4885LMNA 970/4885ALOX12 74/4885
US-10144751-B1 Highly isoselective catalyst for alkene hydroformylation NUDT1, AHR, HMOX2 TSHR 3566/4885LMNA 4177/4885ALOX12 158/4885
US-10376479-B2 Endoxifen compositions and methods CYP46A1, PLA2G2F, VDR TSHR 3322/4885LMNA 1312/4885ALOX12 138/4885
US-20080214860-A1 METHODS FOR THE PREPARATION OF FISPEMIFENE FROM OSPEMIFENE CTSF, CTSE, MME TSHR 3999/4885LMNA 1918/4885ALOX12 2130/4885
US-20180305312-A1 EBNA1 INHIBITORS AND METHODS USING SAME MLLT1, EBNA1BP2, MALT1 TSHR 4040/4885LMNA 897/4885ALOX12 1625/4885
US-20210060106-A1 METHOD FOR OBTAINING SAPONINS FROM PLANTS LSS, GYS2, GYPA TSHR 2877/4885LMNA 1314/4885ALOX12 3304/4885
US-20120164075-A1 ENDOXIFEN METHODS AND COMPOSITIONS IN THE TREATMENT OF MAMMALIAN DISEASES ENPP2, ERAL1, LITAF TSHR 2970/4885LMNA 728/4885ALOX12 78/4885
US-20190231687-A1 ENDOXIFEN METHODS AND COMPOSITIONS IN THE TREATMENT OF PSYCHIATRIC AND NEURODEGENERATIVE DISEASES NLN, BDNF, LITAF TSHR 2821/4885LMNA 970/4885ALOX12 74/4885
US-20030225130-A1 Triphenylalkene derivatives and their use as selective estrogen receptor modulators ESR2, ESR1, GPER1 TSHR 59/4885LMNA 4585/4885ALOX12 1674/4885
US-20100292190-A1 NOVEL TUBULIN POLYMERISATION INHIBITORS TUBB1, TUBA1C, TUBB TSHR 4488/4885LMNA 2644/4885ALOX12 4874/4885
US-20210177752-A1 ENDOXIFEN METHODS AND COMPOSITIONS FOR INHIBITION OF PROTEIN KINASE C EEF2K, LITAF, RAPGEF3 TSHR 3254/4885LMNA 948/4885ALOX12 891/4885
US-10351583-B2 Highly isoselective catalyst for alkene hydroformylation NUDT1, AHR, HMOX2 TSHR 3566/4885LMNA 4177/4885ALOX12 158/4885
US-10981867-B2 EBNA1 inhibitors and methods using same MLLT1, EBNA1BP2, MALT1 TSHR 4040/4885LMNA 897/4885ALOX12 1625/4885
US-10183961-B1 Highly isoselective catalyst for alkene hydroformylation ADH1A, ADH5, HACL2 TSHR 4248/4885LMNA 4020/4885ALOX12 250/4885
US-20190161508-A1 HIGHLY ISOSELECTIVE CATALYST FOR ALKENE HYDROFORMYLATION NUDT1, AHR, HMOX2 TSHR 3566/4885LMNA 4177/4885ALOX12 158/4885
US-20090299070-A1 Organic Semiconductors and Their Manufacture YBX1, CDYL, PROX1 TSHR 4313/4885LMNA 3254/4885ALOX12 3765/4885
US-20100021385-A1 BENZOXAZOLE DERIVATIVES CBX7, KIT, BMX TSHR 3935/4885LMNA 10/4885ALOX12 3388/4885
US-20100168154-A1 1-SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND CACNA1S, CACNA1E, CACNA1B TSHR 3390/4885LMNA 2055/4885ALOX12 2436/4885
US-20100273840-A1 WATER-SOLUBLE POLYMER-BASED CANTHARIMIDES AS POTENTIALLY SELECTIVE ANTI-TUMOR AGENTS HRH3, OXGR1, OXSR1 TSHR 1164/4885LMNA 4674/4885ALOX12 1743/4885
US-20020137925-A1 Regioisomerically pure oxochlorins and methods of synthesis DDT, AOC1, DNMT1 TSHR 3249/4885LMNA 3578/4885ALOX12 336/4885
US-11672758-B2 Endoxifen methods and compositions for inhibition of protein kinase C EEF2K, LITAF, RAPGEF3 TSHR 3254/4885LMNA 948/4885ALOX12 891/4885
US-20120309768-A1 NOVEL TUBULIN POLYMERISATION INHIBITORS TUBB1, TUBA1C, TUBB TSHR 4488/4885LMNA 2644/4885ALOX12 4874/4885
US-20110207944-A1 VITAMIN D3 LACTAM DERIVATIVE VDR, CYP24A1, CYP2R1 TSHR 1981/4885LMNA 942/4885ALOX12 392/4885
US-11912659-B2 EBNA1 inhibitors and methods using same MLLT1, EBNA1BP2, MALT1 TSHR 4040/4885LMNA 897/4885ALOX12 1625/4885
US-10442763-B2 EBNA1 inhibitors and methods using same MLLT1, EBNA1BP2, MALT1 TSHR 4040/4885LMNA 897/4885ALOX12 1625/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.