Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.55 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.47 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.47 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.45 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.45 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.45 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.45 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | RECQL | P46063 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12101207 | 0.98 | AOC3 (0.60) | AOC3PTGS1PTGS2KDM4ERECQL | |
| SCHEMBL412315 | 0.98 | AOC3 (0.60) | AOC3PTGS1PTGS2KDM4ERECQL | |
| SCHEMBL11423964 | 0.88 | TAAR1 (0.54) | AOC3PTGS1PTGS2KDM4ERECQL | |
| SCHEMBL851228 | 0.81 | KDM4E (0.47) | AOC3KDM4ERECQLTDP1MAPT | |
| SCHEMBL837030 | 0.81 | KDM4E (0.47) | AOC3KDM4ERECQLTDP1MAPT | |
| SCHEMBL13057154 | 0.81 | AOC3 (0.60) | AOC3PTGS1PTGS2KDM4ETDP1 | |
| SCHEMBL1744600 | 0.80 | PTGS1 (0.59) | AOC3PTGS1PTGS2KDM4EMAPT | |
| SCHEMBL20559648 | 0.80 | PTGS1 (0.59) | AOC3PTGS1PTGS2KDM4EMAPT | |
| SCHEMBL3669879 | 0.80 | PTGS1 (0.59) | AOC3PTGS1PTGS2KDM4EMAPT | |
| SCHEMBL17541509 | 0.80 | PTGS1 (0.64) | AOC3PTGS1PTGS2POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738632-B2 | Phenyl and benzodioxinyl substituted indazoles derivatives | ASTRAZENECA AB (SE) | 2017-08-22 | — | — | US | disclosed |
| US-20170081315-A1 | Phenyl and benzodioxinyl substituted indazoles derivatives | ASTRAZENECA AB (SE) | 2017-03-23 | — | — | US | disclosed |
| US-9512110-B2 | Phenyl and benzodioxinyl substituted indazoles derivatives | ASTRAZENECA AB (SE) | 2016-12-06 | — | — | US | disclosed |
| EP-2291369-B1 | BENZODIOXINYL SUBSTITUTED INDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2015-11-04 | — | — | EP | disclosed |
| US-20150080434-A1 | PHENYL AND BENZODIOXINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2015-03-19 | — | — | US | disclosed |
| US-8916600-B2 | Phenyl and benzodioxinyl substituted indazoles derivatives | ASTRAZENECA AB (SE) | 2014-12-23 | — | — | US | disclosed |
| EP-2620435-A1 | Phenyl and benzodioxinyl substituted indazole derivatives | Astrazeneca AB (SE) | 2013-07-31 | — | — | EP | disclosed |
| US-20120302617-A1 | Phenyl and Benzodioxinyl Substituted Indazoles Derivatives | ASTRAZENECA AB (SE) | 2012-11-29 | — | — | US | disclosed |
| US-20120252770-A1 | Chemical Compounds 572 | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-10-04 | — | — | US | disclosed |
| EP-2097384-B1 | INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS | ASTRAZENECA AB (SE) | 2012-09-12 | — | — | EP | disclosed |
| EP-2102169-B1 | INDAZOLYL AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2012-06-20 | — | — | EP | disclosed |
| US-8143290-B2 | Chemical compounds 572 | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | disclosed |
| US-20120065173-A1 | CHEMICAL COMPOUNDS | BERGER MARKUS (DE) | 2012-03-15 | — | — | US | disclosed |
| US-8030340-B2 | Moderators of glucocorticoids receptor; antiinflamamtory agents; chronic obstructive pulmonary disease | ASTRAZENECA AB (SE) | 2011-10-04 | — | — | US | disclosed |
| US-20110071194-A1 | Chemical Compounds 572 | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-24 | — | — | US | disclosed |
| US-20100197644-A1 | Chemical Compounds 572 | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-05 | — | — | US | disclosed |
| US-7728030-B2 | Chemical compounds 572 | ASTRAZENECA AB (SE) | 2010-06-01 | — | — | US | disclosed |
| US-20100087489-A1 | Phenyl and Benzodioxinyl Substituted Indazoles Derivatives | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-08 | — | — | US | disclosed |
| US-20080214641-A1 | Chemical compounds 572 | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2008-09-04 | — | — | US | disclosed |
| US-20080207721-A1 | Chemical compounds | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214641-A1 | Chemical compounds 572 | ABCG2, ABCB1, CYP11B2 | PTGS1 168/4885PTGS2 72/4885SLC6A2 3062/4885 |
| US-20100197644-A1 | Chemical Compounds 572 | ABCG2, ABCB1, CYP11B2 | PTGS1 168/4885PTGS2 72/4885SLC6A2 3062/4885 |
| US-20120302617-A1 | Phenyl and Benzodioxinyl Substituted Indazoles Derivatives | CYP3A5, CYP4X1, CYP3A7 | PTGS1 157/4885PTGS2 183/4885SLC6A2 2266/4885 |
| US-20080207721-A1 | Chemical compounds | NR3C1, NR3C2, MC2R | PTGS1 48/4885PTGS2 122/4885SLC6A2 763/4885 |
| US-20150080434-A1 | PHENYL AND BENZODIOXINYL SUBSTITUTED INDAZOLES DERIVATIVES | CYP3A5, ABCB1, CYP4X1 | PTGS1 105/4885PTGS2 104/4885SLC6A2 2069/4885 |
| US-20100087489-A1 | Phenyl and Benzodioxinyl Substituted Indazoles Derivatives | CYP3A5, ABCB1, CYP4X1 | PTGS1 105/4885PTGS2 104/4885SLC6A2 2069/4885 |
| US-20120252770-A1 | Chemical Compounds 572 | ABCG2, ABCB1, CYP11B2 | PTGS1 168/4885PTGS2 72/4885SLC6A2 3062/4885 |
| US-20170081315-A1 | Phenyl and benzodioxinyl substituted indazoles derivatives | CYP3A5, ABCB1, CYP4X1 | PTGS1 105/4885PTGS2 104/4885SLC6A2 2069/4885 |
| US-20120065173-A1 | CHEMICAL COMPOUNDS | NR3C1, NR3C2, MC2R | PTGS1 49/4885PTGS2 124/4885SLC6A2 728/4885 |
| US-20110071194-A1 | Chemical Compounds 572 | ABCG2, ABCB1, CYP11B2 | PTGS1 168/4885PTGS2 72/4885SLC6A2 3062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.