Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 3/20 | 0.41 |
| ▸ | ESR2 known ✓ | Q92731 | 3/20 | 0.41 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.36 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 known ✓ | P08238 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7458893 | 0.98 | LMNA (0.48) | LMNAESR1ESR2MAPTHSD17B10 | |
| Hydrochloric Acid SCHEMBL688812 | 0.77 | KDM4E (0.36) | LMNAMAPTHSD17B10POLBKDM4E | |
| SCHEMBL7464124 | 0.75 | KDM4E (0.37) | LMNAMAPTHSD17B10POLBKDM4E | |
| SCHEMBL1008264 | 0.75 | LMNA (0.45) | LMNAESR1ESR2MAPTHSD17B10 | |
| SCHEMBL1008028 | 0.74 | LMNA (0.53) | LMNAESR1ESR2MAPTHSD17B10 | |
| SCHEMBL1007592 | 0.74 | LMNA (0.53) | LMNAESR1ESR2MAPTHSD17B10 | |
| SCHEMBL7798103 | 0.73 | LMNA (0.46) | LMNAESR1ESR2MAPTHSD17B10 | |
| SCHEMBL1008031 | 0.71 | LMNA (0.56) | LMNAESR1ESR2MAPTHSD17B10 | |
| SCHEMBL1007907 | 0.66 | KDM4E (0.41) | LMNAMAPTHSD17B10POLBKDM4E | |
| SCHEMBL1007294 | 0.65 | LMNA (0.47) | LMNAESR1ESR2MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 156 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12133906-B2 | Delivery particle | THE PROCTER & GAMBLE COMPANY (US) | 2024-11-05 | — | — | US | disclosed |
| US-20220409497-A1 | DELIVERY PARTICLE | PROCTER & GAMBLE (US) | 2022-12-29 | — | — | US | disclosed |
| EP-3733827-A1 | DELIVERY PARTICLES | The Procter & Gamble Company (US) | 2020-11-04 | — | — | EP | disclosed |
| EP-2563508-B1 | DELIVERY PARTICLE | PROCTER & GAMBLE (US) | 2019-07-10 | — | — | EP | disclosed |
| EP-1642563-B1 | Method of rapid hair dyeing | NOXELL CORP (US) | 2019-06-26 | — | — | EP | disclosed |
| US-20190142714-A1 | DELIVERY PARTICLE | PROCTER & GAMBLE (US) | 2019-05-16 | — | — | US | disclosed |
| EP-1484048-B1 | Hair colouring compositions | NOXELL CORP (US) | 2019-01-02 | — | — | EP | disclosed |
| US-20180360706-A1 | Delivery Particles | PROCTER & GAMBLE (US) | 2018-12-20 | — | — | US | disclosed |
| EP-2308564-B1 | Thickened hair colourant and bleaching compositions | NOXELL CORP (US) | 2018-12-19 | — | — | EP | disclosed |
| US-9993793-B2 | Delivery particles | THE PROCTER & GAMBLE COMPANY (US) | 2018-06-12 | — | — | US | disclosed |
| US-20050193502-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | PROCTER, GAMBLE COMPANY, THE | 2005-09-08 | — | — | US | disclosed |
| US-20050188476-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | PROCTER & GAMBLE COMPANY, THE | 2005-09-01 | — | — | US | disclosed |
| WO-2005079735-A1 | KERATIN DYEING COMPOUNDS, KERATIN DYEING COMPOSITIONS CONTAINING THEM, AND USE THEREOF | THE PROCTER & GAMBLE COMPANY (US) | 2005-09-01 | — | — | WO | disclosed |
| WO-2005077324-A1 | KERATIN DYEING COMPOUNDS, KERATIN DYEING COMPOSITIONS CONTAINING THEM, AND USE THEREOF | THE PROCTER & GAMBLE COMPANY (US) | 2005-08-25 | — | — | WO | disclosed |
| WO-2005007615-A1 | 2-(AMINO OR SUBSTITUTED AMINO)-5-(SUBSTITUTED OXYMETHYL)-PHENOL COMPOUNDS, DYEING COMPOSITIONS CONTAINING THEM, AND USE THEREOF | THE PROCTER & GAMBLE COMPANY (US) | 2005-01-27 | — | — | WO | disclosed |
| US-20050005370-A1 | 2-(Amino or substituted amino)-5-(substituted oxymethyl)-phenol compounds, dyeing compositions containing them, and use thereof | THE PROCTER & GAMBLE COMPANY | 2005-01-13 | — | — | US | disclosed |
| EP-1484048-A1 | Hair colouring compositions | The Procter & Gamble Company (US) | 2004-12-08 | — | — | EP | disclosed |
| US-20040237218-A1 | Hair colouring compositions | WELLA OPERATIONS US, LLC | 2004-12-02 | — | — | US | disclosed |
| US-20010020310-A1 | Compositions for dyeing keratinous fibres, containing 3-aminopyrazolo[1,5-a]pyrimidines, method of dyeing, and novel 3-aminopyrazolo[1,5-a]pyrimidines | L'OREAL S.A. | 2001-09-13 | — | — | US | disclosed |
| US-6248137-B1 | Compositions for dyeing keratinous fibres, containing 3-aminopyrazolo [1,5-a]pyrimidines, method of dyeing and novel 3-aminopyrazolo [1,5-a]pyrimidines | L'OREAL S.A. (FR) | 2001-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220409497-A1 | DELIVERY PARTICLE | LIPA, CHMP4B, SLC46A1 | ESR1 3962/4885ESR2 3837/4885GAA 347/4885 |
| US-20180360706-A1 | Delivery Particles | LIPA, CHMP4B, ABCB4 | ESR1 3803/4885ESR2 3653/4885GAA 384/4885 |
| US-20010020310-A1 | Compositions for dyeing keratinous fibres, containing 3-aminopyrazolo[1,5-a]pyrimidines, method of dyeing, and novel 3-aminopyrazolo[1,5-a]pyrimidines | DPYD, KRT18, PNPO | ESR1 4845/4885ESR2 4764/4885GAA 4049/4885 |
| US-20050005370-A1 | 2-(Amino or substituted amino)-5-(substituted oxymethyl)-phenol compounds, dyeing compositions containing them, and use thereof | KRT18, LOX, TYR | ESR1 2907/4885ESR2 1044/4885GAA 3854/4885 |
| US-12133906-B2 | Delivery particle | LIPA, CHMP4B, SLC46A1 | ESR1 3962/4885ESR2 3837/4885GAA 347/4885 |
| US-20190142714-A1 | DELIVERY PARTICLE | LIPA, CHMP4B, SLC46A1 | ESR1 3962/4885ESR2 3837/4885GAA 347/4885 |
| US-20040237218-A1 | Hair colouring compositions | COXFA4L2, CYBA, MT-CO3 | ESR1 4244/4885ESR2 3757/4885GAA 2644/4885 |
| US-20050188476-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | KRT18, JUP, CKMT1A; CKMT1B | ESR1 3344/4885ESR2 2004/4885GAA 4686/4885 |
| US-20050193502-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | KRT18, KLK5, CKMT1A; CKMT1B | ESR1 3812/4885ESR2 2318/4885GAA 3490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.