Hydrochloric Acid

Hydrochloric Acid

SCHEMBL496928

Cl.Cl.O=C(O)CCNCCNCCC(=O)O

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 known ✓ O15379 1/20 0.38
HDAC1 known ✓ Q13547 1/20 0.38
HDAC2 known ✓ Q92769 1/20 0.38
HDAC8 known ✓ Q9BY41 1/20 0.38
S1PR1 known ✓ P21453 1/20 0.37
S1PR3 known ✓ Q99500 1/20 0.37
LMNA P02545 3/20 0.47
EGLN1 Q9GZT9 2/20 0.47
ALKBH5 Q6P6C2 1/20 0.47
SUCNR1 Q9BXA5 1/20 0.47
ECE1 P42892 1/20 0.42
SLC22A6 Q4U2R8 1/20 0.42
TSHR P16473 3/20 0.40
NFKB1 P19838 1/20 0.40
PMP22 Q01453 1/20 0.40
KDM4E B2RXH2 2/20 0.39
KDM5C P41229 2/20 0.39
PHF8 Q9UPP1 2/20 0.39
KDM2A Q9Y2K7 2/20 0.39
KDM6B O15054 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8650017 1.00 LMNA (0.47) LMNAEGLN1ALKBH5SUCNR1ECE1
Hydrochloric Acid SCHEMBL6306661 1.00 LMNA (0.47) LMNAEGLN1ALKBH5SUCNR1ECE1
Hydrochloric Acid SCHEMBL4199437 0.97 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1ECE1
SCHEMBL12491912 0.97 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1ECE1
SCHEMBL5035377 0.97 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1ECE1
SCHEMBL17433002 0.97 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1ECE1
SCHEMBL20415450 0.97 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1ECE1
SCHEMBL162041 0.97 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1ECE1
SCHEMBL109879 0.94 LMNA (0.53) LMNAEGLN1ALKBH5SUCNR1ECE1
SCHEMBL28473579 0.90 LMNA (0.50) LMNAEGLN1ALKBH5SUCNR1ECE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 343 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11963761-B2 Mediation of in vivo analyte signal degradation SENSEONICS, INCORPORATED (US) 2024-04-23 US claimed
US-11744248-B2 Disinfectant composition for control of clostridium difficile spore ENVIRO SPECIALTY CHEMICALS INC. (US) 2023-09-05 US claimed
EP-3847889-A1 BIOCIDAL COMPOSITIONS COMPRISING IRON CHELATORS Arch Chemicals, Inc. (US) 2021-07-14 EP claimed
US-20200359943-A1 MEDIATION OF IN VIVO ANALYTE SIGNAL DEGRADATION SENSEONICS, INCORPORATED (US) 2020-11-19 US claimed
US-20200170249-A1 Biocidal Compositions Comprising Iron Chelators ARCH CHEMICALS, INC. 2020-06-04 US claimed
WO-2019040374-A1 DISINFECTANT COMPOSITION FOR CONTROL OF CLOSTRIDIUM DIFFICILE SPORES ENVIRO SPECIALTY CHEMICALS INC. (US) 2019-02-28 WO claimed
US-20190053494-A1 DISINFECTANT COMPOSITION FOR CONTROL OF CLOSTRIDIUM DIFFICILE SPORE ENVIRO SPECIALTY CHEMICALS, INC. 2019-02-21 US claimed
US-20180318402-A1 COMPOSITIONS AND METHODS COMPRISING SERRATIA PEPTIDASE FOR INHIBITION AND TREATMENT OF BIOFILMS RELATED TO CERTAIN CONDITIONS PROTHERA LLC (US) 2018-11-08 US claimed
US-9987337-B2 Compositions and methods comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions PROTHERA, INC. (US) 2018-06-05 US claimed
US-9737591-B2 Compositions and methods comprising serratia peptidase for inhibition of bacterial vaginosis, bacterial vaginitis or fungal vaginitis PROTHERA, INC. (US) 2017-08-22 US claimed
EP-1781312-A2 FORMULATIONS AND METHODS FOR MODULATING SATIETY Rosenberg, Mark (US) 2007-05-09 EP claimed
EP-1017427-B1 USE OF A COMPOSITION COMPRISING A CHELATING AGENT AND AN ANTIMICROBIAL COMPOUND FOR THE TREATMENT OF BIOFILMS UNIV TEXAS (US) 2006-04-26 EP claimed
WO-2006023976-A2 FORMULATIONS AND METHODS FOR MODULATING SATIETY ROSENBERG MARK (US) 2006-03-02 WO claimed
US-20050143286-A1 such as lactoferrin, conalbumin; combinations with antibiotics, microbiocides for e.g. disinfecting, preserving food, treating infections; also chelating agents such as ,19,30-trioxa-1,4,10,13,16,22,27,33-octaazabicyclo(11,11,11)pentatriacontane hexahydrobromide THE UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2005-06-30 US claimed
US-6852495-B2 Process of extracting nucleic acid and process of simultaneously carrying out extraction and purification of nucleic acid SHIMADZU CORPORATION (JP) 2005-02-08 US claimed
EP-1499341-A2 METHODS OF INHIBITING AND TREATING BACTERIAL BIOFILMS BY METAL CHELATORS THE UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2005-01-26 EP claimed
US-20030229222-A1 Process of extracting nucleic acid and process of simultaneously carrying out extraction and purification of nucleic acid SHIMADZU CORPORATION (JP) 2003-12-11 US claimed
WO-2003088914-A2 METHODS OF INHIBITING AND TREATING BACTERIAL BIOFILMS BY METAL CHELATORS THE UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2003-10-30 WO claimed
US-6267979-B1 PROVIDINY AQUEOUS SYSTEM FORMULATION COMPRISING CHELATING AGENT, AN ANTIMICROBIAL TO CONTROL GROWTH OF MICROORGANISMS WAKE FOREST UNIVERSITY 2001-07-31 US claimed
EP-0716149-A1 METHOD OF DETERMINING SODIUM ION KYOWA MEDEX CO., LTD. (JP) 1996-06-12 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11744248-B2 Disinfectant composition for control of clostridium difficile spore EPCAM, DSTN, DSG1 HDAC3 349/4885HDAC1 660/4885HDAC2 1026/4885
US-20190053494-A1 DISINFECTANT COMPOSITION FOR CONTROL OF CLOSTRIDIUM DIFFICILE SPORE EPCAM, DSTN, DSG1 HDAC3 349/4885HDAC1 660/4885HDAC2 1026/4885
US-20200170249-A1 Biocidal Compositions Comprising Iron Chelators SLC40A1, TFRC, SLC39A14 HDAC3 2695/4885HDAC1 1287/4885HDAC2 2370/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.