Hydrochloric Acid

Hydrochloric Acid

SCHEMBL504482

Cl.Nc1ccc(-c2ccc(N)c(N)c2)cc1N

nearest known ligand 0.93

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 known ✓ Q12809 2/20 0.58
CYP19A1 known ✓ P11511 2/20 0.50
GAA known ✓ P10253 2/20 0.42
HSP90AA1 known ✓ P07900 1/20 0.42
ESR2 known ✓ Q92731 1/20 0.41
TDP1 Q9NUW8 6/20 0.93
KMT2A Q03164 5/20 0.93
MEN1 O00255 4/20 0.93
CYP3A4 P08684 8/20 0.57
ALDH1A1 P00352 7/20 0.57
TSHR P16473 4/20 0.57
MAPK1 P28482 2/20 0.57
ALOX15 P16050 6/20 0.52
HSD17B10 Q99714 5/20 0.52
CYP17A1 P05093 2/20 0.50
CYP11B1 P15538 2/20 0.50
CYP11B2 P19099 2/20 0.50
SMN1; SMN2 Q16637 3/20 0.48
TP53 P04637 1/20 0.48
THRB P10828 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2565398 1.00 TDP1 (0.93) TDP1KMT2AMEN1KCNH2CYP3A4
Hydrochloric Acid SCHEMBL29378721 1.00 TDP1 (0.93) TDP1KMT2AMEN1KCNH2CYP3A4
Hydrochloric Acid SCHEMBL29497777 1.00 TDP1 (0.93) TDP1KMT2AMEN1KCNH2CYP3A4
Hydrochloric Acid SCHEMBL874057 1.00 TDP1 (0.93) TDP1KMT2AMEN1KCNH2CYP3A4
Hydrochloric Acid SCHEMBL94882 1.00 TDP1 (0.93) TDP1KMT2AMEN1KCNH2CYP3A4
Hydrochloric Acid SCHEMBL30078382 0.97 TDP1 (0.88) TDP1KMT2AMEN1KCNH2CYP3A4
Hydrochloric Acid SCHEMBL28836366 0.97 TDP1 (0.88) TDP1KMT2AMEN1KCNH2CYP3A4
Hydrochloric Acid SCHEMBL1646515 0.97 TDP1 (0.88) TDP1KMT2AMEN1KCNH2CYP3A4
Hydrochloric Acid SCHEMBL9355084 0.97 TDP1 (0.88) TDP1KMT2AMEN1KCNH2CYP3A4
Hydrochloric Acid SCHEMBL866164 0.97 TDP1 (0.88) TDP1KMT2AMEN1KCNH2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116144513-A Fermented rubidium laginella with selenium-enriched and antibacterial functions and application thereof 自然资源部第三海洋研究所 2023-05-23 CN claimed
CN-106365243-B Abandon a class type rainwater deep cycle purifier and purification process thereof 徐州工程学院 2020-09-08 CN claimed
CN-107006683-B Selenium-rich fermented silkworm chrysalis and preparation method thereof 安徽省农业科学院蚕桑研究所 2020-06-16 CN claimed
CN-107034262-B X-ray genetic marker probe based on synchronous light source and preparation method and application thereof 中国科学院上海应用物理研究所 2020-01-03 CN claimed
CN-103243412-B Preparation method of high-performance organic fibers on basis of 3,3'4,4'-tetra-aminobiphenyl hydrochloride UNIV HEILONGJIANG 2015-04-08 CN claimed
CN-103243412-A Preparation method of high-performance organic fibers on basis of 3,3'4,4'-tetra-aminobiphenyl hydrochloride UNIV HEILONGJIANG 2013-08-14 CN claimed
US-12577266-B2 Protein proximity assay in formalin fixed paraffin embedded tissue using caged haptens VENTANA MEDICAL SYSTEMS, INC. (US) 2026-03-17 US disclosed
US-12559511-B2 Protein proximity assay in formalin fixed paraffin embedded tissue using caged haptens VENTANA MEDICAL SYSTEMS, INC. (US) 2026-02-24 US disclosed
US-20250066397-A1 PROTEIN PROXIMITY ASSAY IN FORMALIN FIXED PAFFAFIN EMBEDDED TISSUE USING CAGED HAPTENS VENTANA MED SYST INC (US) 2025-02-27 US disclosed
US-12173019-B2 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens VENTANA MEDICAL SYSTEMS, INC. (US) 2024-12-24 US disclosed
EP-3504549-B1 PROTEIN PROXIMITY ASSAY IN FORMALIN FIXED PARAFFIN EMBEDDED TISSUE USING CAGED HAPTENS VENTANA MED SYST INC (US) 2024-12-11 EP disclosed
EP-3341734-B1 PROTEIN PROXIMITY ASSAY IN FORMALIN FIXED PAFFAFIN EMBEDDED TISSUE USING CAGED HAPTENS VENTANA MED SYST INC (US) 2024-08-07 EP disclosed
US-20240100099-A1 COMPOSITION FOR REGENERATION OF INTERVERTEBRAL DISC NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) 2024-03-28 US disclosed
US-5143830-A PROCESS FOR THE PRODUCTION OF A POLYPEPTIDE UNIVERSITY OF LEICESTER (GB) 1992-09-01 US disclosed
EP-0484863-A1 A monoclonal antibody and a method for measuring malondialdehyde-reacted low-density-lipoproteins DAIICHI PURE CHEMICALS CO. LTD. (JP) 1992-05-13 EP disclosed
US-5041506-A Method for the production of a molecular composite of rigid aromatic polymer HONDA GIKEN KOGYO KABUSHIKI KAISHA (JP) 1991-08-20 US disclosed
EP-0361768-A2 Enzyme-nucleic acid hydrazone and hydrazide conjugate compositions, probes and methods SISKA DIAGNOSTICS,INC. (US) 1990-04-04 EP disclosed
EP-0298753-A2 Method for the production of a molecular composite HONDA GIKEN KOGYO KABUSHIKI KAISHA (JP) 1989-01-11 EP disclosed
EP-0267224-A1 PROCESS FOR THE PRODUCTION OF A POLYPEPTIDE. HOLLAND IAN BARRY (GB) 1988-05-18 EP disclosed
WO-1987006953-A1 PROCESS FOR THE PRODUCTION OF A POLYPEPTIDE HOLLAND IAN BARRY (GB) 1987-11-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12173019-B2 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens PAFAH1B2, PAFAH1B3, PAF1 KCNH2 4568/4885CYP19A1 4009/4885GAA 4506/4885
US-12559511-B2 Protein proximity assay in formalin fixed paraffin embedded tissue using caged haptens PTMS, MKI67, ACP1 KCNH2 1406/4885CYP19A1 2512/4885GAA 2180/4885
US-20250066397-A1 PROTEIN PROXIMITY ASSAY IN FORMALIN FIXED PAFFAFIN EMBEDDED TISSUE USING CAGED HAPTENS PAFAH1B2, PAFAH1B3, PAF1 KCNH2 4568/4885CYP19A1 4009/4885GAA 4506/4885
US-12577266-B2 Protein proximity assay in formalin fixed paraffin embedded tissue using caged haptens ACP1, AOX1, PTMS KCNH2 3903/4885CYP19A1 3826/4885GAA 3535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.