Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.33 |
| ▸ | HTR6 known ✓ | P50406 | 1/20 | 0.33 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 4/20 | 0.31 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.31 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.31 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.31 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.31 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.31 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.31 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.31 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.31 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.31 |
| ▸ | CACNA1B known ✓ | Q00975 | 1/20 | 0.31 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.31 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.31 |
| ▸ | RET known ✓ | P07949 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5839045 | 1.00 | HTR2A (0.33) | HTR2AKDM4EHTR6MEN1PMP22 | |
| Bromide SCHEMBL6910226 | 0.98 | KDM4E (0.33) | HTR2AKDM4EHTR6MEN1PMP22 | |
| SCHEMBL144110 | 0.98 | HTR2A (0.34) | HTR2AKDM4EHTR6MEN1PMP22 | |
| SCHEMBL29474419 | 0.98 | HTR2A (0.34) | HTR2AKDM4EHTR6MEN1PMP22 | |
| Methane SCHEMBL5838214 | 0.96 | HTR2A (0.33) | HTR2AKDM4EHTR6MEN1PMP22 | |
| Chloromethane SCHEMBL3682989 | 0.95 | HTR6 (0.33) | HTR2AKDM4EHTR6SIGMAR1BRD4 | |
| Butane SCHEMBL6918003 | 0.91 | HTR2A (0.34) | HTR2AKDM4EHTR6MEN1PMP22 | |
| SCHEMBL1617737 | 0.87 | SIGMAR1 (0.38) | HTR2AHTR6SIGMAR1KCNH2 | |
| SCHEMBL6917289 | 0.85 | GPR3 (0.31) | HTR2AKDM4EBRD4CCL2LMNA | |
| (Chloromethyl)Benzene SCHEMBL7040024 | 0.85 | SIGMAR1 (0.36) | HTR2AHTR6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 281 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10676547-B2 | Aluminum alkyls with pendant olefins on clays | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2020-06-09 | — | — | US | claimed |
| US-20180201700-A1 | Aluminum Alkyls with Pendant Olefins on Clays | EXXONMOBIL CHEMICAL PATENTS INC. | 2018-07-19 | — | — | US | claimed |
| EP-2822975-B1 | POLYOLEFIN ADHESIVE COMPOSITIONS AND METHODS OF PREPARING THE SAME | EXXONMOBIL CHEMICAL PATENTS INC (US) | 2018-04-25 | — | — | EP | claimed |
| EP-2460834-B1 | Improved acidic activator-supports and catalysts for olefin polymerization | CHEVRON PHILLIPS CHEMICAL CO (US) | 2015-08-12 | — | — | EP | claimed |
| EP-1807456-B1 | ORGANOCHROMIUM/METALLOCENE COMBINATION CATALYST FOR PRODUCING BIMODAL RESINS | CHEVRON PHILLIPS CHEMICAL CO (US) | 2012-07-11 | — | — | EP | claimed |
| EP-1799726-B1 | TRIALKYLALUMINUM TREATED SUPPORTS | EXXONMOBIL CHEM PATENTS INC (US) | 2011-07-13 | — | — | EP | claimed |
| US-7741417-B2 | Preparation of polymerization catalyst activators utilizing indole-modified silica supports | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2010-06-22 | — | — | US | claimed |
| US-7385015-B2 | Trialkylaluminum treated supports | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2008-06-10 | — | — | US | claimed |
| EP-1799726-A1 | TRIALKYLALUMINUM TREATED SUPPORTS | Exxonmobil Chemical Patents Inc. (US) | 2007-06-27 | — | — | EP | claimed |
| US-7220695-B2 | Supported activator | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-05-22 | — | — | US | claimed |
| US-20030207762-A9 | CATALYST PREPARATION METHOD | UNIVATION TECHNOLOGIES, LLC | 2003-11-06 | — | — | US | claimed |
| US-20030134990-A1 | Polymerizations using adjuvant catalysts | HUNTSMAN POLYMERS CORPORATION | 2003-07-17 | — | — | US | claimed |
| US-20020119890-A1 | Catalyst preparation method | WENZEL TIMOTHY T (US) | 2002-08-29 | — | — | US | claimed |
| US-20020103310-A1 | Catalyst composition, method of polymerization and polymer therefrom | UNIVATION TECHNOLOGIES, LLC | 2002-08-01 | — | — | US | claimed |
| US-20010047064-A1 | Polymerizations using adjuvant catalyst | HUNTSMAN POLYMERS CORPORATION (US) | 2001-11-29 | — | — | US | claimed |
| EP-1090047-A1 | POLYMERIZATIONS USING ADJUVANT CATALYST | Huntsman Polymers Corporation (US) | 2001-04-11 | — | — | EP | claimed |
| EP-0824554-B1 | AMORPHOUS OLEFIN CO/TER-POLYMERS | OPTATECH CORP (FI) | 2000-03-01 | — | — | EP | claimed |
| WO-1999057164-A1 | POLYMERIZATIONS USING ADJUVANT CATALYST | HUNTSMAN POLYMERS CORPORATION (US) | 1999-11-11 | — | — | WO | claimed |
| EP-0822938-B1 | ENHANCED SYNTHESIS OF RACEMIC METALLOCENES | ALBEMARLE CORP (US) | 1999-06-16 | — | — | EP | claimed |
| EP-0798315-B1 | Process for preparing highly active, stable metallocene catalyst systems, and catalyst compositions prepared according therewith | WITCO GMBH (DE) | 1997-10-29 | — | — | EP | claimed |