Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.38 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.31 |
| ▸ | CSF1R known ✓ | P07333 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 7/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3575823 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL2052546 | 0.83 | CYP1A2 (0.37) | ALDH1A1KCNH2CYP1A2CYP2C9CYP2D6 | |
| SCHEMBL859959 | 0.82 | — | — | |
| SCHEMBL859677 | 0.80 | — | — | |
| SCHEMBL20755604 | 0.80 | — | — | |
| SCHEMBL4324417 | 0.80 | — | — | |
| SCHEMBL13066711 | 0.80 | — | — | |
| SCHEMBL21945129 | 0.80 | KCNH2 (0.37) | ALDH1A1KCNH2CYP1A2CYP2C9CYP2D6 | |
| SCHEMBL10155081 | 0.80 | RAF1 (0.33) | ALDH1A1KMT2APOLB | |
| SCHEMBL24618609 | 0.77 | KCNH2 (0.38) | ALDH1A1KCNH2CYP1A2CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6911410-B2 | Catalyst composition containing an aluminoxane for dimerizing, co-dimerizing and oligomerizing olefins | INSTITUT FRANCAIS DU PETROLE (FR) | 2005-06-28 | — | — | US | claimed |
| EP-1136123-B1 | Catalytic composition and catalytic process of dimerisation, codimerisation and oligomerisation of olefins | INST FRANCAIS DU PETROLE (FR) | 2005-05-25 | — | — | EP | claimed |
| EP-1138388-B1 | Catalytic composition for dimerisation, codimerisation and oligomerisation of olefins | INST FRANCAIS DU PETROLE (FR) | 2005-04-06 | — | — | EP | claimed |
| US-6706657-B2 | USING COORDINATION CATALYST | INSTITUT FRANCAIS DU PETROLE (FR) | 2004-03-16 | — | — | US | claimed |
| US-20030181775-A1 | Catalyst composition containing an aluminoxane for dimerizing, co-dimerizing and oligomerizing olefins | INSTITUT FRANCAIS DU PETROLE (FR) | 2003-09-25 | — | — | US | claimed |
| EP-1122230-B1 | Process for the selective dimerisation of propylene principally to ramified dimers | INST FRANCAIS DU PETROLE (FR) | 2003-06-25 | — | — | EP | claimed |
| US-20030109766-A1 | Catalytic composition for dimerizing, co-dimerizing and oligomerizing olefins | INSTITUT FRANCAIS DU PETROLE (FR) | 2003-06-12 | — | — | US | claimed |
| US-6501001-B2 | USING NICKEL COMPOUND OR COMPLEX | INSTITUT FRANCAIS DU PETROLE (FR) | 2002-12-31 | — | — | US | claimed |
| US-20010049398-A1 | Catalytic composition and process for the catalysis of dimerization codimerization and oligomerization of olefins | INSTITUT FRANCAIS DU PETROLE (FR) | 2001-12-06 | — | — | US | claimed |
| US-20010018546-A1 | Process for selective dimerization of propylene principally into branched dimers | INSTITUT FRANCAIS DU PETROLE (FR) | 2001-08-30 | — | — | US | claimed |
| EP-0646412-B1 | Catalyst composition and process for the dimerisation of olefins | INST FRANCAIS DU PETROLE (FR) | 1999-05-19 | — | — | EP | claimed |
| EP-0709356-B1 | Catalytic composition and aliphatic hydrocarbon alkylation process | INST FRANCAIS DU PETROLE (FR) | 1999-01-13 | — | — | EP | claimed |
| US-5852130-A | Catalytic composition based on transition metal complexes, and a process for the hydrogenation of unsaturated compounds | INSTITUT FRANCAIS DU PETROLE (FR) | 1998-12-22 | — | — | US | claimed |
| US-5780702-A | Process for displacing the double bond in olefins using a catalytic composition based on transition metal complexes | INSTITUT FRANCAIS DU PETROLE (FR) | 1998-07-14 | — | — | US | claimed |
| US-5750455-A | Catalytic composition and process for the alkylation of aliphatic hydrocarbons | INSTITUT FRANCAIS DU PETROLE (FR) | 1998-05-12 | — | — | US | claimed |
| US-5693585-A | CATALYST CONSISTING OF POROUS SUPPORT IMPREGNATED WITH ALUMINUM HALIDE, QUATERNARY AMMONIUM HALIDE AND/OR AMINE HYDROHALIDE, CUPROUS COMPOUND | INSTITUT FRANCAIS DU PETROLE (FR) | 1997-12-02 | — | — | US | claimed |
| US-5675051-A | Catalytic composition and olefin disproportion process | INSTITUT FRANCAIS DU PETROLE (FR) | 1997-10-07 | — | — | US | claimed |
| US-5550306-A | Catalytic process for the dimerization of olefins | INSTITUT FRANCAIS DU PETROLE (FR) | 1996-08-27 | — | — | US | claimed |
| US-5536689-A | Catalytic composition and a process for the dimerization of olefins | INSTITUT FRANCAIS DU PETROLE (FR) | 1996-07-16 | — | — | US | claimed |
| US-5525567-A | Catalytic composition and olefin disproportion process | INSTITUT FRANCAIS DU PETROLE (FR) | 1996-06-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010049398-A1 | Catalytic composition and process for the catalysis of dimerization codimerization and oligomerization of olefins | NOTUM, HDHD5, COG7 | KCNH2 3827/4885GAA 1405/4885CSF1R 4508/4885 |
| US-20030181775-A1 | Catalyst composition containing an aluminoxane for dimerizing, co-dimerizing and oligomerizing olefins | AP1M1, AP2M1, COG7 | KCNH2 3970/4885GAA 4287/4885CSF1R 3126/4885 |
| US-20010018546-A1 | Process for selective dimerization of propylene principally into branched dimers | AP1M1, PHPT1, TAF1 | KCNH2 2750/4885GAA 2293/4885CSF1R 3962/4885 |
| US-20030109766-A1 | Catalytic composition for dimerizing, co-dimerizing and oligomerizing olefins | NOTUM, PHOSPHO1, ADH5 | KCNH2 3670/4885GAA 3283/4885CSF1R 4315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.