Hydrochloric Acid

Hydrochloric Acid

SCHEMBL7873578

Cl.Cl.Cl.Cl.Nc1ccc(S(=O)(=O)c2ccc(N)c(N)c2)cc1N

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 known ✓ P50406 2/20 0.79
GAA known ✓ P10253 3/20 0.61
CA2 known ✓ P00918 5/20 0.45
ALDH1A1 P00352 5/20 0.79
PKM P14618 3/20 0.79
MAPT P10636 3/20 0.61
KMT2A Q03164 5/20 0.59
MEN1 O00255 3/20 0.59
KDM4E B2RXH2 3/20 0.59
RAB9A P51151 1/20 0.59
LMNA P02545 3/20 0.50
CYP2C9 P11712 2/20 0.50
MPO P05164 1/20 0.50
CYP3A4 P08684 1/20 0.50
TSHR P16473 1/20 0.50
CA12 O43570 5/20 0.45
CA1 P00915 5/20 0.45
CA9 Q16790 5/20 0.45
CA4 P22748 4/20 0.45
CA6 P23280 4/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6659575 0.97 ALDH1A1 (0.83) ALDH1A1PKMHTR6GAAMAPT
SCHEMBL29462648 0.97 ALDH1A1 (0.83) ALDH1A1PKMHTR6GAAMAPT
SCHEMBL636445 0.97 ALDH1A1 (0.83) ALDH1A1PKMHTR6GAAMAPT
SCHEMBL29484233 0.97 ALDH1A1 (0.83) ALDH1A1PKMHTR6GAAMAPT
SCHEMBL30771551 0.89 HTR6 (1.00) ALDH1A1PKMHTR6GAAMAPT
SCHEMBL728291 0.89 HTR6 (1.00) ALDH1A1PKMHTR6GAAMAPT
SCHEMBL30166976 0.87 HTR6 (0.74) ALDH1A1PKMHTR6GAAMAPT
SCHEMBL950448 0.87 HTR6 (0.74) ALDH1A1PKMHTR6GAAMAPT
Hydrochloric Acid SCHEMBL8019338 0.86 LMNA (0.74) ALDH1A1PKMHTR6GAAMAPT
SCHEMBL28822994 0.85 ALDH1A1 (0.71) ALDH1A1PKMHTR6GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5443859-A Reacting tetracarboxylic acid dianhydride, aromatic diamine, optionally polyamine, to form polyamic acid, forming film, imidizing to form polyimide, carbonizing in inert gas or vacuum to form carbon film with specifed properties TOHO RAYON CO., LTD. (JP) 1995-08-22 US claimed
US-6320019-B1 REACTING A TETRACARBOXYLIC DIANHYDRIDE, AN AROMATIC DIAMINE, A DIAMINE WITH A SILOXANE STRUCTURE, AND AN AROMATIC TRI- OR TETRAAMINE WITH TWO PHENYL GROUPS SAEHAN INDUSTRIES INCORPORATION (KR) 2001-11-20 US disclosed
EP-0716113-B1 Polyamic acid having three-dimensional network molecular structure, polyimide obtained therefrom and process for the preparation thereof TOHO RAYON KK (JP) 2000-01-19 EP disclosed
EP-0716113-A2 Polyamic acid having three-dimensional network molecular structure, polyimide obtained therefrom and process for the preparation thereof Toho Rayon Co., Ltd. (JP) 1996-06-12 EP disclosed
US-5443859-A Reacting tetracarboxylic acid dianhydride, aromatic diamine, optionally polyamine, to form polyamic acid, forming film, imidizing to form polyimide, carbonizing in inert gas or vacuum to form carbon film with specifed properties TOHO RAYON CO., LTD. (JP) 1995-08-22 US disclosed
US-5352524-A The carbon fiber sheet is derived from a polyimides of polyamic acid; tensile strength, electroconductivity, elasticity TOHO RAYON CO., LTD. (JP) 1994-10-04 US disclosed
US-5231162-A Polyamic acid having three-dimensional network molecular structure, polyimide obtained therefrom and process for the preparation thereof TOHO RAYON CO. LTD. (JP) 1993-07-27 US disclosed
EP-0418889-A2 Polyamic acid having three-dimensional network molecular structure, polyimide obtained therefrom and process for the preparation thereof Toho Rayon Co., Ltd. (JP) 1991-03-27 EP disclosed