Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Carbromal. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 3/20 | 0.38 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.36 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.36 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.35 |
| ▸ | HDAC3 known ✓ | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 known ✓ | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 known ✓ | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 known ✓ | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 known ✓ | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 known ✓ | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 known ✓ | Q9UQL6 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbromal SCHEMBL11407016 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2L3MBTL1MAPTNR3C1RIPK1 | |
| Carbromal SCHEMBL6907293 | 0.98 | SMN1; SMN2 (0.40) | SMN1; SMN2L3MBTL1MAPTNR3C1RIPK1 | |
| Carbromal SCHEMBL4373766 | 0.91 | SOAT1 (0.41) | MMP13ALDH1A1GAAHTTHDAC3 | |
| Carbromal SCHEMBL4373776 | 0.91 | SOAT1 (0.41) | MMP13ALDH1A1GAAHTTHDAC3 | |
| Carbromal SCHEMBL10826028 | 0.89 | NR3C1 (0.39) | NR3C1RIPK1ALDH1A1GAAHDAC3 | |
| Carbromal SCHEMBL8536554 | 0.88 | CRBN (0.36) | NR3C1RIPK1HDAC3HDAC4HDAC1 | |
| Carbromal SCHEMBL11576940 | 0.87 | KMO (0.46) | SMN1; SMN2ALDH1A1 | |
| Carbromal SCHEMBL5473912 | 0.87 | NR3C1 (0.38) | L3MBTL1MAPTNR3C1RIPK1ALDH1A1 | |
| Carbromal SCHEMBL2139358 | 0.87 | NR3C1 (0.40) | NR3C1RIPK1ALDH1A1GAAHDAC3 | |
| Carbromal SCHEMBL6249616 | 0.86 | CRBN (0.37) | MAPTNR3C1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118165319-A | Silicon-containing heterocyclic aramid film with high-temperature energy storage and electric etching resistance and preparation method thereof | 四川大学 | 2024-06-11 | — | — | CN | claimed |
| CN-118156513-A | Composite base film, composite current collector, negative electrode plate and lithium battery | 浙江中科玖源新材料有限公司 | 2024-06-07 | — | — | CN | claimed |
| CN-117482757-A | High-flux positively charged magnesium-lithium separation nanofiltration membrane and preparation method thereof | 天津大学 | 2024-02-02 | — | — | CN | claimed |
| CN-116854967-A | High-temperature energy storage fluorine-containing aromatic polyamide dielectric film and preparation method thereof | 四川大学 | 2023-10-10 | — | — | CN | claimed |
| CN-116832626-A | High-flux seawater desalination reverse osmosis membrane and preparation method thereof | 浙江易膜新材料科技有限公司 | 2023-10-03 | — | — | CN | claimed |
| CN-116272418-A | Reverse osmosis composite membrane and preparation method thereof | 湖南沁森高科新材料有限公司 | 2023-06-23 | — | — | CN | claimed |
| CN-115608172-B | Seawater boron-removing reverse osmosis membrane and preparation method and application thereof | 湖南沁森高科新材料有限公司 | 2023-04-28 | — | — | CN | claimed |
| CN-115090130-B | Nanofiltration membrane containing silica gel nanoparticle intermediate layer and preparation method thereof | 浙江美易膜科技有限公司 | 2023-04-25 | — | — | CN | claimed |
| CN-115220305-A | Positive photosensitive resin composition and preparation method and application thereof | 明士(北京)新材料开发有限公司 | 2022-10-21 | — | — | CN | claimed |
| CN-113910571-A | High-performance aramid fiber insulating film and preparation method thereof | 株洲时代华先材料科技有限公司 | 2022-01-11 | — | — | CN | claimed |
| CN-109942810-B | Aromatic heterocyclic polyamide composite film with high breakdown strength and preparation method thereof | 四川大学 | 2021-07-23 | — | — | CN | claimed |
| CN-118156513-A | Composite base film, composite current collector, negative electrode plate and lithium battery | 浙江中科玖源新材料有限公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-117959947-A | Clay lithium extraction film for strengthening two-dimensional channel constraint and preparation method thereof | 武汉理工大学 | 2024-05-03 | — | — | CN | disclosed |
| CN-117181002-B | Seawater desalination membrane and preparation method thereof | 湖南沁森高科新材料有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-117181002-A | Seawater desalination membrane and preparation method thereof | 湖南沁森高科新材料有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-101506267-A | Weather-and heat-stable polymers with improved flow components | SABIC INNOVATIVE PLASTICS IP (NL) | 2009-08-12 | — | — | CN | disclosed |
| CN-1550254-A | Composite semipermeable membrane and process for producing the same | �ն��繤��ʽ���� | 2004-12-01 | — | — | CN | disclosed |
| EP-0589891-A1 | HIGH COMPRESSIVE STRENGTH LIQUID CRYSTALLINE POLYMERS AND FIBERS AND FILMS THEREOF | FOSTER-MILLER INC. (US) | 1994-04-06 | — | — | EP | disclosed |
| EP-0589891-A4 | HIGH COMPRESSIVE STRENGTH LIQUID CRYSTALLINE POLYMERS AND FIBERS AND FILMS THEREOF. | FOSTER MILLER INC (US) | 1993-11-11 | — | — | EP | disclosed |
| WO-1992014776-A1 | HIGH COMPRESSIVE STRENGTH LIQUID CRYSTALLINE POLYMERS AND FIBERS AND FILMS THEREOF | FOSTER-MILLER, INC. (US) | 1992-09-03 | — | — | WO | disclosed |