Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methionine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 10/20 | 0.47 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.47 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 4/20 | 0.44 |
| ▸ | NOS1 | P29475 | 4/20 | 0.44 |
| ▸ | NOS3 | P29474 | 3/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racemethionine SCHEMBL9990635 | 1.00 | BHMT (0.47) | BHMTBHMT2RNPEPNOS2NOS1 | |
| Racemethionine SCHEMBL8983115 | 0.88 | BHMT (0.57) | BHMTBHMT2RNPEPNOS2NOS1 | |
| Methionine SCHEMBL4226 | 0.88 | — | — | |
| Methionine SCHEMBL162030 | 0.88 | BHMT (0.57) | BHMTBHMT2RNPEPNOS2NOS1 | |
| Racemethionine SCHEMBL287590 | 0.88 | BHMT (0.57) | BHMTBHMT2RNPEPNOS2NOS1 | |
| Racemethionine SCHEMBL23361954 | 0.88 | BHMT (0.57) | BHMTBHMT2RNPEPNOS2NOS1 | |
| Racemethionine SCHEMBL126688 | 0.88 | — | — | |
| Racemethionine SCHEMBL5617580 | 0.88 | BHMT (0.57) | BHMTBHMT2RNPEPNOS2NOS1 | |
| Methionine SCHEMBL5584463 | 0.88 | BHMT (0.57) | BHMTBHMT2RNPEPNOS2NOS1 | |
| Racemethionine SCHEMBL9504290 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612370-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-04-28 | — | — | US | disclosed |
| US-12577209-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-03-17 | — | — | US | disclosed |
| US-12577210-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-03-17 | — | — | US | disclosed |
| US-12540119-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-02-03 | — | — | US | disclosed |
| US-12522568-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-01-13 | — | — | US | disclosed |
| US-12473261-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2025-11-18 | — | — | US | disclosed |
| US-12448357-B1 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2025-10-21 | — | — | US | disclosed |
| US-20250171406-A1 | AMINO ACID COMPOSITIONS | THERMOLIFE INTERNATIONAL, LLC | 2025-05-29 | — | — | US | disclosed |
| US-20250162998-A1 | AMINO ACID COMPOSITIONS | THERMOLIFE INTERNATIONAL, LLC | 2025-05-22 | — | — | US | disclosed |
| US-20250163001-A1 | AMINO ACID COMPOSITIONS | THERMOLIFE INTERNATIONAL, LLC | 2025-05-22 | — | — | US | disclosed |
| US-10426792-B1 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2019-10-01 | — | — | US | disclosed |
| US-10426750-B1 | Amino acid supplement formulations | THERMOLIFE INTERNATIONAL, LLC (US) | 2019-10-01 | — | — | US | disclosed |
| US-8957101-B1 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2015-02-17 | — | — | US | disclosed |
| US-8957100-B1 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2015-02-17 | — | — | US | disclosed |
| US-8952045-B1 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2015-02-10 | — | — | US | disclosed |
| US-8952046-B1 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2015-02-10 | — | — | US | disclosed |
| US-8466187-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2013-06-18 | — | — | US | disclosed |
| US-8455531-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2013-06-04 | — | — | US | disclosed |
| US-8344014-B2 | — | — | 2013-01-01 | — | — | US | disclosed |
| US-20110313043-A1 | Amino Acid Compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12473261-B2 | Amino acid compositions | ASNS, GLUL, ARGLU1 | BHMT 1897/4885BHMT2 570/4885RNPEP 310/4885 |
| US-12612370-B2 | Amino acid compositions | TNNT2, NPR1, NOS2 | BHMT 1049/4885BHMT2 640/4885RNPEP 295/4885 |
| US-12448357-B1 | Amino acid compositions | SLC6A15, SLC1A5, SLC6A19 | BHMT 761/4885BHMT2 180/4885RNPEP 63/4885 |
| US-12540119-B2 | Amino acid compositions | NOS2, NOS1, NOS3 | BHMT 302/4885BHMT2 171/4885RNPEP 1184/4885 |
| US-12577209-B2 | Amino acid compositions | ARG1, NOS1, NOS2 | BHMT 1312/4885BHMT2 1013/4885RNPEP 471/4885 |
| US-20250171406-A1 | AMINO ACID COMPOSITIONS | ASNS, GLUL, ARGLU1 | BHMT 1929/4885BHMT2 565/4885RNPEP 297/4885 |
| US-12577210-B2 | Amino acid compositions | NPR1, SLC1A5, SLC6A15 | BHMT 1529/4885BHMT2 768/4885RNPEP 586/4885 |
| US-20250162998-A1 | AMINO ACID COMPOSITIONS | ASNS, SLC1A5, BCAT2 | BHMT 1186/4885BHMT2 206/4885RNPEP 169/4885 |
| US-20110313043-A1 | Amino Acid Compositions | ARGLU1, AADAT, MUSK | BHMT 71/4885BHMT2 164/4885RNPEP 110/4885 |
| US-10426750-B1 | Amino acid supplement formulations | ARGLU1, ARG1, PYGM | BHMT 99/4885BHMT2 191/4885RNPEP 768/4885 |
| US-10426792-B1 | Amino acid compositions | SLC10A2, SLC6A6, SLC6A15 | BHMT 128/4885BHMT2 126/4885RNPEP 715/4885 |
| US-20250163001-A1 | AMINO ACID COMPOSITIONS | ASNS, GLUL, ARGLU1 | BHMT 1897/4885BHMT2 570/4885RNPEP 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.