Hydrochloric Acid

Hydrochloric Acid

SCHEMBL16369796

Cl.Cl.O=C1C(=O)c2cc3ccccc3cc2C(O)=C1O

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 known ✓ P56524 1/20 0.38
HDAC2 known ✓ Q92769 1/20 0.38
HDAC8 known ✓ Q9BY41 1/20 0.38
BCHE known ✓ P06276 2/20 0.37
MAOA known ✓ P21397 2/20 0.37
S1PR4 known ✓ O95977 1/20 0.37
S1PR1 known ✓ P21453 1/20 0.37
PPARG known ✓ P37231 1/20 0.37
GSTP1 known ✓ P09211 1/20 0.36
TOP1 known ✓ P11387 1/20 0.36
GAA known ✓ P10253 1/20 0.36
ESR1 known ✓ P03372 1/20 0.35
MAOB known ✓ P27338 1/20 0.35
ESR2 known ✓ Q92731 1/20 0.35
APAF1 O14727 2/20 0.48
TDP2 O95551 2/20 0.48
MCL1 Q07820 2/20 0.43
BCL2 P10415 1/20 0.43
NQO1 P15559 1/20 0.41
P2RX7 Q99572 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29488106 0.98 APAF1 (0.50) APAF1TDP2MCL1BCL2NQO1
SCHEMBL244695 0.98 APAF1 (0.50) APAF1TDP2MCL1BCL2NQO1
SCHEMBL11352933 0.94 APAF1 (0.46) APAF1TDP2MCL1BCL2NQO1
SCHEMBL3465719 0.94 APAF1 (0.46) APAF1TDP2MCL1BCL2NQO1
SCHEMBL8190848 0.87 APAF1 (0.64) APAF1TDP2MCL1BCL2NQO1
SCHEMBL7120454 0.80 S100A4 (0.41) APAF1TDP2MCL1BCL2NQO1
SCHEMBL27981640 0.80 APAF1 (0.41) APAF1TDP2MCL1BCL2NQO1
SCHEMBL19230417 0.79 ALDH1A1 (0.52) APAF1TDP2MCL1BCL2CES2
SCHEMBL30130196 0.77 MEN1 (0.56) APAF1TDP2MCL1BCL2CES2
SCHEMBL354514 0.77 MEN1 (0.56) APAF1TDP2MCL1BCL2CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3019201-B1 PHOTOACTIVATABLE LIPID-BASED NANOPARTICLES AS VEHICLES FOR DUAL AGENT DELIVERY US HEALTH (US) 2020-03-18 EP disclosed
US-10117942-B2 Photoactivatable lipid-based nanoparticles as vehicles for dual agent delivery THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2018-11-06 US disclosed
US-20160136289-A1 PHOTOACTIVATABLE LIPID-BASED NANOPARTICLES AS VEHICLES FOR DUAL AGENT DELIVERY THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2016-05-19 US disclosed
EP-3019201-A1 PHOTOACTIVATABLE LIPID-BASED NANOPARTICLES AS VEHICLES FOR DUAL AGENT DELIVERY The U.S.A. As Represented By The Secretary, Department Of Health And Human Services (US) 2016-05-18 EP disclosed
WO-2015006429-A1 PHOTOACTIVATABLE LIPID-BASED NANOPARTICLES AS VEHICLES FOR DUAL AGENT DELIVERY THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2015-01-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10117942-B2 Photoactivatable lipid-based nanoparticles as vehicles for dual agent delivery PHOSPHO1, DCPS, DPP8 HDAC4 2763/4885HDAC2 1831/4885HDAC8 107/4885
US-20160136289-A1 PHOTOACTIVATABLE LIPID-BASED NANOPARTICLES AS VEHICLES FOR DUAL AGENT DELIVERY PHOSPHO1, DCPS, DPP8 HDAC4 2763/4885HDAC2 1831/4885HDAC8 107/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.