Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 known ✓ | P56524 | 1/20 | 0.49 |
| ▸ | HDAC3 known ✓ | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HTR7 known ✓ | P34969 | 3/20 | 0.47 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.44 |
| ▸ | VSIR | Q9H7M9 | 1/20 | 0.51 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | AGXT | P21549 | 1/20 | 0.46 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.45 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.45 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3089631 | 0.99 | VSIR (0.52) | VSIRHDAC4MEF2DGBA1PIM1 | |
| SCHEMBL6238716 | 0.85 | MEN1 (0.51) | HDAC4MEF2DGBA1HTR7AGXT | |
| SCHEMBL6239823 | 0.84 | MAPT (0.50) | HDAC4MEF2DGBA1HTR7AGXT | |
| SCHEMBL22163952 | 0.82 | MAPT (0.55) | GBA1HDAC6ALDH1A1MAPTGLA | |
| SCHEMBL28756272 | 0.81 | AGXT (0.52) | HDAC4MEF2DPIM1KMOHDAC3 | |
| SCHEMBL17320558 | 0.81 | HDAC4 (0.49) | VSIRHDAC4MEF2DPIM1KMO | |
| SCHEMBL11935022 | 0.80 | SYK (0.49) | HDAC4MEF2DPIM1KMOHDAC3 | |
| SCHEMBL19623431 | 0.79 | HDAC1 (0.56) | HDAC4MEF2DPIM1KMOHDAC3 | |
| SCHEMBL27970512 | 0.79 | LMNA (0.53) | HDAC4MEF2DPIM1KMOHDAC3 | |
| Hydrochloric Acid SCHEMBL2086926 | 0.79 | LMNA (0.53) | HDAC4MEF2DPIM1KMOHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1707242-B2 | Oxidative hair colouring composition comprising 1,5- and /or 2,7-dihydroxy naphthalene and at least one further coupling agent | HENKEL AG & CO KGAA (DE) | 2015-06-03 | — | — | EP | claimed |
| EP-1868688-A2 | OXIDATION DYES COMPRISING 2-FURANONES AND COLLAGEN (DERIVATIVES) | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2007-12-26 | — | — | EP | claimed |
| EP-1726289-A2 | Dyeing composition for keratin fibres which contains a reducing agent | Henkel Kommanditgesellschaft auf Aktien (DE) | 2006-11-29 | — | — | EP | claimed |
| WO-2006108505-A2 | OXIDATION DYES COMPRISING 2-FURANONES AND COLLAGEN (DERIVATIVES) | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2006-10-19 | — | — | WO | claimed |
| EP-1707242-A1 | Oxidative hair colouring composition comprising 1,5- and /or 2,7-dihydroxy naphthalene and at least one further coupling agent | Henkel Kommanditgesellschaft auf Aktien (DE) | 2006-10-04 | — | — | EP | claimed |
| WO-2006018089-A1 | OXIDATION COLORANTS COMPRISING DIAMINOBENZENE DERIVATIVES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2006-02-23 | — | — | WO | claimed |
| EP-1825884-B1 | Brightening and/or colouring agent with reduced potential for irritation | HENKEL AG & CO KGAA (DE) | 2017-08-16 | — | — | EP | disclosed |
| EP-1813260-B1 | Bleaching and/or colouring agent with reduced potential for irritation | HENKEL AG & CO KGAA (DE) | 2017-05-31 | — | — | EP | disclosed |
| EP-1813259-B1 | Bleaching and/or colouring agent with reduced potential for irritation | HENKEL AG & CO KGAA (DE) | 2017-04-19 | — | — | EP | disclosed |
| EP-1813258-B1 | Bleaching and/or colouring agent with reduced potential for irritation | HENKEL AG & CO KGAA (DE) | 2017-04-19 | — | — | EP | disclosed |
| EP-1707242-B2 | Oxidative hair colouring composition comprising 1,5- and /or 2,7-dihydroxy naphthalene and at least one further coupling agent | HENKEL AG & CO KGAA (DE) | 2015-06-03 | — | — | EP | disclosed |
| EP-1707242-B1 | Oxidative hair colouring composition comprising 1,5- and /or 2,7-dihydroxy naphthalene and at least one further coupling agent | HENKEL AG & CO KGAA (DE) | 2011-10-05 | — | — | EP | disclosed |
| US-20090304620-A1 | HAIR TREATMENT PRODUCTS COMPRISING POLYMERS | HENKEL AG & CO. KGAA (DE) | 2009-12-10 | — | — | US | disclosed |
| EP-1813259-A2 | Bleaching and/or colouring agent with reduced potential for irritation | Henkel Kommanditgesellschaft auf Aktien (DE) | 2007-08-01 | — | — | EP | disclosed |
| EP-1813260-A2 | Bleaching and/or colouring agent with reduced potential for irritation | Henkel Kommanditgesellschaft auf Aktien (DE) | 2007-08-01 | — | — | EP | disclosed |
| EP-1726289-A2 | Dyeing composition for keratin fibres which contains a reducing agent | Henkel Kommanditgesellschaft auf Aktien (DE) | 2006-11-29 | — | — | EP | disclosed |
| WO-2006108505-A2 | OXIDATION DYES COMPRISING 2-FURANONES AND COLLAGEN (DERIVATIVES) | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2006-10-19 | — | — | WO | disclosed |
| EP-1707242-A1 | Oxidative hair colouring composition comprising 1,5- and /or 2,7-dihydroxy naphthalene and at least one further coupling agent | Henkel Kommanditgesellschaft auf Aktien (DE) | 2006-10-04 | — | — | EP | disclosed |
| EP-1707242-A1 | Oxidative hair colouring composition comprising 1,5- and /or 2,7-dihydroxy naphthalene and at least one further coupling agent | Henkel Kommanditgesellschaft auf Aktien (DE) | 2006-10-04 | — | — | EP | disclosed |
| WO-2006018089-A1 | OXIDATION COLORANTS COMPRISING DIAMINOBENZENE DERIVATIVES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090304620-A1 | HAIR TREATMENT PRODUCTS COMPRISING POLYMERS | ASS1, SRM, COL1A1 | HDAC4 1644/4885HDAC3 3161/4885HDAC1 944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.