Hydrochloric Acid

Hydrochloric Acid

SCHEMBL3333887

Cc1cc(OCCO)c(N)cc1N.Cl

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA known ✓ P10253 3/20 0.40
HSP90AA1 known ✓ P07900 1/20 0.36
HSP90AB1 known ✓ P08238 1/20 0.36
ALDH1A1 P00352 7/20 0.40
POLB P06746 4/20 0.40
MEN1 O00255 4/20 0.40
MAPT P10636 4/20 0.40
KMT2A Q03164 4/20 0.40
KDM4E B2RXH2 3/20 0.40
CASP7 P55210 2/20 0.40
USP2 O75604 2/20 0.40
CASP1 P29466 2/20 0.40
GFER P55789 1/20 0.40
TP53 P04637 1/20 0.40
HTT P42858 1/20 0.40
ATM Q13315 1/20 0.40
HSD17B10 Q99714 3/20 0.39
ALOX15 P16050 2/20 0.39
CYP1A2 P05177 1/20 0.39
HIF1A Q16665 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL10361244 1.00 ALDH1A1 (0.40) ALDH1A1POLBMEN1MAPTKMT2A
SCHEMBL455549 0.98 ALDH1A1 (0.41) ALDH1A1POLBMEN1MAPTKMT2A
SCHEMBL29353325 0.98 ALDH1A1 (0.41) ALDH1A1POLBMEN1MAPTKMT2A
Sulfuric Acid SCHEMBL5176442 0.90 GAA (0.36) ALDH1A1POLBMEN1MAPTKMT2A
SCHEMBL11706798 0.87 TSHR (0.43) ALDH1A1POLBMEN1MAPTKMT2A
Hydrochloric Acid SCHEMBL1872731 0.86 KDM4E (0.47) ALDH1A1POLBMEN1MAPTKMT2A
Hydrochloric Acid SCHEMBL7167133 0.86 KDM4E (0.47) ALDH1A1POLBMEN1MAPTKMT2A
SCHEMBL5367514 0.86 POLB (0.43) ALDH1A1POLBMEN1MAPTKMT2A
Hydrochloric Acid SCHEMBL9023948 0.86 KDM4E (0.38) ALDH1A1POLBMEN1MAPTKMT2A
SCHEMBL460869 0.84 ALDH1A1 (0.48) ALDH1A1POLBMEN1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114867447-A Multilayer dissolvable solid article comprising solid particles for making multilayer dissolvable solid article 宝洁公司 2022-08-05 CN disclosed
EP-2760425-B1 FOAM OXIDATIVE HAIR COLORANT COMPOSITION WITH THE FREE-BASE OF 1, 4-DIAMINO-2-METHOXMETHYL BENZENE NOXELL CORP (US) 2019-07-31 EP disclosed
EP-1814631-B1 A HIGH AQUEOUS OXIDATION HAIRCOLOR SYSTEM COMBE INC (US) 2015-12-02 EP disclosed
US-8529637-B2 Foam oxidative hair colorant composition with the free-base of 1,4-diamino-2-methoxymethyl benzene THE PROCTER & GAMBLE COMPANY (US) 2013-09-10 US disclosed
US-20130081647-A1 Foam Oxidative Hair Colorant Composition with the Free-Base of 1,4-Diamino-2-Methoxymethyl Benzene THE PROCTER & GAMBLE COMPANY (US) 2013-04-04 US disclosed
US-20100143274-A1 USE OF AMINES AND AMIDES FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS CIBA CORPORATION (US) 2010-06-10 US disclosed
EP-2120846-A2 USE OF AMINES AND AMIDES FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS BASF SE (DE) 2009-11-25 EP disclosed
WO-2008107347-A2 USE OF AMINES AND AMIDES FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS BASF SE (CH) 2008-09-12 WO disclosed
US-7419510-B2 High aqueous oxidation haircolor system COMBE INCORPORATED (US) 2008-09-02 US disclosed
EP-1814631-A2 A HIGH AQUEOUS OXIDATION HAIRCOLOR SYSTEM COMBE INCORPORATED (US) 2007-08-08 EP disclosed
US-20060110379-A1 Linkage of agents using microparticles PERICOR SCIENCE, INC. (US) 2006-05-25 US disclosed
US-20060104966-A1 Transglutaminase linkage of agents to tissue PERICOR SCIENCE, INC. (US) 2006-05-18 US disclosed
WO-2006023842-A2 A HIGH AQUEOUS OXIDATION HAIRCOLOR SYSTEM COMBE INCORPORATED (US) 2006-03-02 WO disclosed
US-20060037153-A1 High aqueous oxidation haircolor system COMBE INCORPORTED 2006-02-23 US disclosed
US-6958148-B1 Linkage of agents to body tissue using microparticles and transglutaminase PERICOR SCIENCE, INC. (US) 2005-10-25 US disclosed
US-6919076-B1 Conjugates of agents and transglutaminase substrate linking molecules PERICOR SCIENCE, INC. (US) 2005-07-19 US disclosed
EP-1202706-A1 LYSINE OXIDASE LINKAGE OF AGENTS TO TISSUE Pericor Science, Inc. (US) 2002-05-08 EP disclosed
WO-2001007009-A1 LYSINE OXIDASE LINKAGE OF AGENTS TO TISSUE PERICOR SCIENCE, INC. (US) 2001-02-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100143274-A1 USE OF AMINES AND AMIDES FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS MAOA, MAOB, ACMSD GAA 999/4885HSP90AA1 1225/4885HSP90AB1 1404/4885
US-20130081647-A1 Foam Oxidative Hair Colorant Composition with the Free-Base of 1,4-Diamino-2-Methoxymethyl Benzene DHODH, AOC1, GPX4 GAA 4659/4885HSP90AA1 3224/4885HSP90AB1 3315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.