Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.41 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.41 |
| ▸ | CASP2 | P42575 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27643100 | 0.98 | TSHR (0.55) | TSHREPHX1FAAHZDHHC20ZDHHC2 | |
| SCHEMBL16176196 | 0.98 | TSHR (0.55) | TSHREPHX1FAAHZDHHC20ZDHHC2 | |
| SCHEMBL27489106 | 0.98 | TSHR (0.55) | TSHREPHX1FAAHZDHHC20ZDHHC2 | |
| SCHEMBL18725606 | 0.98 | TSHR (0.55) | TSHREPHX1FAAHZDHHC20ZDHHC2 | |
| SCHEMBL20427935 | 0.98 | TSHR (0.55) | TSHREPHX1FAAHZDHHC20ZDHHC2 | |
| SCHEMBL8154331 | 0.96 | TSHR (0.52) | TSHREPHX1FAAHZDHHC20ZDHHC2 | |
| SCHEMBL4609619 | 0.91 | TSHR (0.48) | TSHREPHX1ALDH1A1CNR2 | |
| SCHEMBL28507521 | 0.89 | TSHR (0.47) | TSHREPHX1ALDH1A1CNR2 | |
| Hydrochloric Acid SCHEMBL4449709 | 0.85 | ALDH1A1 (0.44) | TSHRALDH1A1 | |
| SCHEMBL28013640 | 0.85 | EPHX1 (0.52) | EPHX1FAAHZDHHC20ZDHHC2CASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 151 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106176250-B | Tooth adhesive system based on new hydrophobic adhesion concept | 浙江大学 | 2020-06-23 | — | — | CN | claimed |
| CN-106137774-B | Pit and fissure sealant based on tooth surface hydrophobization concept | 浙江大学 | 2020-04-17 | — | — | CN | claimed |
| US-20240164993-A1 | ORGANOSILICON COMPOUND AND DENTAL COMPOSITION CONTAINING SAME | KURARAY NORITAKE DENTAL INC. (JP) | 2024-05-23 | — | — | US | disclosed |
| EP-4364718-A1 | DENTAL CURABLE COMPOSITION | Kuraray Noritake Dental Inc. (JP) | 2024-05-08 | — | — | EP | disclosed |
| US-20240139078-A1 | DENTAL FILLING KIT | KURARAY NORITAKE DENTAL INC. (JP) | 2024-05-02 | — | — | US | disclosed |
| EP-4360609-A1 | DENTAL ADHESIVE KIT | Kuraray Noritake Dental Inc. (JP) | 2024-05-01 | — | — | EP | disclosed |
| US-20240091107-A1 | DENTAL COMPOSITION | KURARAY NORITAKE DENTAL INC. (JP) | 2024-03-21 | — | — | US | disclosed |
| US-20240074945-A1 | CURABLE COMPOSITION FOR DENTAL RESTORATION | KURARAY NORITAKE DENTAL INC. (JP) | 2024-03-07 | — | — | US | disclosed |
| US-20240074946-A1 | DENTAL COMPOSITION | KURARAY NORITAKE DENTAL INC. (JP) | 2024-03-07 | — | — | US | disclosed |
| EP-4324450-A1 | DENTAL FILLING KIT | Kuraray Noritake Dental Inc. (JP) | 2024-02-21 | — | — | EP | disclosed |
| EP-3936109-B1 | SOLVENT-FREE ADHESIVE COMPOSITION FOR DENTAL USE | KURARAY NORITAKE DENTAL INC (JP) | 2024-02-14 | — | — | EP | disclosed |
| EP-1695685-A1 | ONE-PACK TYPE ADHESIVE COMPOSITION FOR DENTAL USE | Kuraray Medical Inc. (JP) | 2006-08-30 | — | — | EP | disclosed |
| EP-1057468-B1 | Adhesive composition and method for producing it | KURARAY CO (JP) | 2006-07-19 | — | — | EP | disclosed |
| US-20060078510-A1 | Dental coating kit | KURARAY MEDICAL INC. (JP) | 2006-04-13 | — | — | US | disclosed |
| EP-1550428-A1 | DENTAL COATING KIT | Kuraray Medical Inc. (JP) | 2005-07-06 | — | — | EP | disclosed |
| US-6887920-B2 | Fillings and composite dental materials containing the fillings | KURARAY CO., LTD. (JP) | 2005-05-03 | — | — | US | disclosed |
| US-20030060533-A1 | A metal oxide and a water-soluble metal salt each forming an independent phase; high water resistance and high acid resistance, and high releasing abilities of ions such as fluorine ions | KURARAY NORITAKE DENTAL INC. (JP) | 2003-03-27 | — | — | US | disclosed |
| US-6512068-B1 | Substantially transparent adhesive composition for hard tissue, and a method for producing it; the adhesive composition exhibits good adhesiveness to hard tissue, especially to both enamel and dentin, and has the advantage of | KURARAY CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1270688-A1 | FILLINGS AND COMPOSITE DENTAL MATERIALS CONTAINING THE FILLINGS | KURARAY CO., LTD. (JP) | 2003-01-02 | — | — | EP | disclosed |
| EP-1057468-A1 | Adhesive composition and method for producing it | KURARAY CO., LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240074946-A1 | DENTAL COMPOSITION | PIEZO1, TAS2R42, EIF2B3 | HSP90AA1 103/4885TSHR 3861/4885EPHX1 3937/4885 |
| US-20240139078-A1 | DENTAL FILLING KIT | DHX29, DHX35, DHX15 | HSP90AA1 2188/4885TSHR 4803/4885EPHX1 60/4885 |
| US-20240091107-A1 | DENTAL COMPOSITION | CCT7, TAS2R42, CCT5 | HSP90AA1 105/4885TSHR 3718/4885EPHX1 3257/4885 |
| US-20240074945-A1 | CURABLE COMPOSITION FOR DENTAL RESTORATION | SMCHD1, WDR26, KAT6A | HSP90AA1 230/4885TSHR 3667/4885EPHX1 3003/4885 |
| US-20240164993-A1 | ORGANOSILICON COMPOUND AND DENTAL COMPOSITION CONTAINING SAME | MSL1, ITGA1, ASH2L | HSP90AA1 2023/4885TSHR 4172/4885EPHX1 861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.