Hydrochloric Acid

Hydrochloric Acid

SCHEMBL3674757

CC(C(=O)O)(c1ccccc1)c1ccccc1.Cl

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 known ✓ O15379 1/20 0.59
HDAC4 known ✓ P56524 1/20 0.59
HDAC1 known ✓ Q13547 1/20 0.59
HDAC7 known ✓ Q8WUI4 1/20 0.59
HDAC2 known ✓ Q92769 1/20 0.59
HDAC10 known ✓ Q969S8 1/20 0.59
HDAC11 known ✓ Q96DB2 1/20 0.59
HDAC8 known ✓ Q9BY41 1/20 0.59
HDAC6 known ✓ Q9UBN7 1/20 0.59
HDAC9 known ✓ Q9UKV0 1/20 0.59
HDAC5 known ✓ Q9UQL6 1/20 0.59
CHRM2 known ✓ P08172 1/20 0.43
CHRM4 known ✓ P08173 1/20 0.43
CHRM5 known ✓ P08912 1/20 0.43
CHRM1 known ✓ P11229 1/20 0.43
CHRM3 known ✓ P20309 1/20 0.43
ESR1 known ✓ P03372 2/20 0.43
ESR2 known ✓ Q92731 2/20 0.43
MAPT P10636 2/20 0.52
KMT2A Q03164 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL73063 0.97 HDAC3 (0.61) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrogen Sulfide SCHEMBL27894390 0.95 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC7HDAC2
Bromide SCHEMBL27764653 0.95 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL28079333 0.95 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrogen Sulfide SCHEMBL28066375 0.95 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL28727492 0.95 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC7HDAC2
Bromomethane SCHEMBL209562 0.95 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL28079327 0.95 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL28079189 0.95 HDAC3 (0.59) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrochloric Acid SCHEMBL27886095 0.93 HDAC3 (0.57) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7851483-B2 administering a salt of 7-[(2,2-diphenylpropanoyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane and a steroid selected from flunisolide, beclomethasone, triamcinolone, budesonide, fluticasone, mometasone, ciclesonide, rofleponide or dexamethasone, for the treatment of asthma or COPD BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2010-12-14 US disclosed
EP-2104500-A2 SUBSTITUTED PIPERIZINES FOR THE TREATMENT OF PAIN Merck & Co., Inc. (US) 2009-09-30 EP disclosed
US-20090155185-A1 MEDICAMENTS FOR INHALATION COMPRISING AN ANTICHOLINERGIC AND A BETAMIMETIC MEADE CHRISTOPHER JOHN MONTAGUE 2009-06-18 US disclosed
US-7417051-B2 Medicaments comprising betamimetics and a novel anticholinergic BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2008-08-26 US disclosed
US-20080139578-A1 Substituted piperizines for the treatment of pain MERCK & CO., INC. 2008-06-12 US disclosed
WO-2008066803-A2 SUBSTITUTED PIPERIZINES FOR THE TREATMENT OF PAIN MERCK & CO, INC. (US) 2008-06-05 WO disclosed
US-20060276441-A1 Medicaments comprising steroids and a novel anticholinergic BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2006-12-07 US disclosed
US-7084153-B2 Medicaments comprising steroids and a novel anticholinergic BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2006-08-01 US disclosed
US-20050025718-A1 Medicaments for inhalation comprising an anticholinergic and a betamimetic BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-02-03 US disclosed
US-20040010003-A1 9,9-dimethyl-3-oxa-9-azoniumtricyclo(3.3.1.0(2,4))nonanyl 2,2-diphenylpropionate quaternary salt BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-01-15 US disclosed
US-20040002502-A1 Medicament combinations comprising heterocyclic compounds and a novel anticholinergic BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-01-01 US disclosed
US-20030223937-A1 Medicaments comprising steroids and a novel anticholinergic BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2003-12-04 US disclosed
US-4140770-A Benzoylethers and processes for their production A. NATTERMANN & CIE. GMBH (DE) 1979-02-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080139578-A1 Substituted piperizines for the treatment of pain TRPV1, TRPA1, TRPV5 HDAC3 1592/4885HDAC4 965/4885HDAC1 911/4885
US-20040002502-A1 Medicament combinations comprising heterocyclic compounds and a novel anticholinergic CHRM3, ACHE, CHRM2 HDAC3 560/4885HDAC4 981/4885HDAC1 1278/4885
US-20090155185-A1 MEDICAMENTS FOR INHALATION COMPRISING AN ANTICHOLINERGIC AND A BETAMIMETIC ADRB2, CHRM3, ADRB1 HDAC3 3565/4885HDAC4 3560/4885HDAC1 2950/4885
US-20050025718-A1 Medicaments for inhalation comprising an anticholinergic and a betamimetic ADRB2, CHRM3, ADRB1 HDAC3 3565/4885HDAC4 3560/4885HDAC1 2950/4885
US-20030223937-A1 Medicaments comprising steroids and a novel anticholinergic CHRM3, CHRM2, CHRNB1 HDAC3 2339/4885HDAC4 1356/4885HDAC1 1263/4885
US-20040010003-A1 9,9-dimethyl-3-oxa-9-azoniumtricyclo(3.3.1.0(2,4))nonanyl 2,2-diphenylpropionate quaternary salt ADRB1, ADRB3, ADRB2 HDAC3 2796/4885HDAC4 3450/4885HDAC1 2484/4885
US-20060276441-A1 Medicaments comprising steroids and a novel anticholinergic CHRM3, CHRNB1, ADRB2 HDAC3 2404/4885HDAC4 1378/4885HDAC1 1557/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.