Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 8-Hydroxy Quinaldine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 known ✓ | P51681 | 1/20 | 0.54 |
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.51 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.48 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.48 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.48 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 2/20 | 0.92 |
| ▸ | PLAU | P00749 | 1/20 | 0.55 |
| ▸ | NCF1 | P14598 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | CCR1 | P32246 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 8-Hydroxy Quinaldine SCHEMBL4762935 | 0.98 | METAP2 (0.96) | METAP2PLAUNCF1RAB9ACCR1 | |
| 8-Hydroxy Quinaldine SCHEMBL9386783 | 0.98 | METAP2 (0.96) | METAP2PLAUNCF1RAB9ACCR1 | |
| 8-Hydroxy Quinaldine SCHEMBL29885026 | 0.98 | METAP2 (0.96) | METAP2PLAUNCF1RAB9ACCR1 | |
| 8-Hydroxy Quinaldine SCHEMBL28867186 | 0.98 | METAP2 (0.96) | METAP2PLAUNCF1RAB9ACCR1 | |
| 8-Hydroxy Quinaldine SCHEMBL4401768 | 0.98 | METAP2 (0.96) | METAP2PLAUNCF1RAB9ACCR1 | |
| 8-Hydroxy Quinaldine SCHEMBL27483916 | 0.96 | METAP2 (0.92) | METAP2PLAUNCF1RAB9ACCR1 | |
| 8-Hydroxy Quinaldine SCHEMBL29483489 | 0.96 | METAP2 (1.00) | METAP2PLAUNCF1RAB9ACCR1 | |
| 8-Hydroxy Quinaldine SCHEMBL297247 | 0.96 | METAP2 (1.00) | METAP2PLAUNCF1RAB9ACCR1 | |
| 8-Hydroxy Quinaldine SCHEMBL4286984 | 0.94 | METAP2 (0.96) | METAP2PLAUNCF1RAB9ACCR1 | |
| 8-Hydroxy Quinaldine SCHEMBL4304584 | 0.94 | METAP2 (0.96) | METAP2PLAUNCF1RAB9ACCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10756287-B2 | Light-emitting element, light-emitting device, electronic device, and lighting device | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2020-08-25 | — | — | US | disclosed |
| US-20190088897-A1 | Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2019-03-21 | — | — | US | disclosed |
| US-10103341-B2 | Organometallic complex and light emitting element, light emitting device, and electronic device using the organometallic complex | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2018-10-16 | — | — | US | disclosed |
| EP-2196518-B1 | Light-Emitting Element and Light-Emitting Device | SEMICONDUCTOR ENERGY LAB (JP) | 2018-09-26 | — | — | EP | disclosed |
| US-9985223-B2 | Iridium organometallic complexes comprising 4-arylpyrimidines | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2018-05-29 | — | — | US | disclosed |
| US-9972794-B2 | Organometallic complex, and light-emitting element and display device using the organometallic complex | SEMICONDUCTOR LABORATORY CO., LTD. (JP) | 2018-05-15 | — | — | US | disclosed |
| US-20170294617-A1 | Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2017-10-12 | — | — | US | disclosed |
| US-9698354-B2 | Light-emitting element, light-emitting device, electronic device, and lighting device | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2017-07-04 | — | — | US | disclosed |
| US-20170054093-A1 | Organometallic Complex, and Light-Emitting Element and Display Device Using the Organometallic Complex | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2017-02-23 | — | — | US | disclosed |
| US-9508941-B2 | Light-emitting elements comprising iridium organometallic complexes comprising aryl-substituted pyrazines | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2016-11-29 | — | — | US | disclosed |
| US-20090058278-A1 | Light-Emitting Element, Light-Emitting Device, and Electronic Appliance | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. | 2009-03-05 | — | — | US | disclosed |
| EP-2031036-A1 | Light-emitting element, light-emitting device, and electronic appliance | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2009-03-04 | — | — | EP | disclosed |
| US-20080312437-A1 | Organometallic Complex, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using the Organometallic Complex | SEMICONDUCTOR ENERGY LABRATORY CO., LTD. | 2008-12-18 | — | — | US | disclosed |
| EP-1963346-A1 | ORGANOMETALLIC COMPLEX AND LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE AND ELECTRONIC DEVICE USING THE SAME | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2008-09-03 | — | — | EP | disclosed |
| US-20080160345-A1 | Organometallic complex, and light-emitting element, light-emitting device and electronic device including the organometallic compex | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2008-07-03 | — | — | US | disclosed |
| EP-1939208-A1 | Organometallic complex, and light-emitting element, light-emitting device, and electronic device including the organometallic complex | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2008-07-02 | — | — | EP | disclosed |
| EP-1873163-A1 | Organometallic complex and light emitting element, light emitting device, and electronic device using the organometallic complex | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2008-01-02 | — | — | EP | disclosed |
| US-20070244320-A1 | Organometallic complex and light emitting element, light emitting device, and electronic device using the organometallic complex | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. | 2007-10-18 | — | — | US | disclosed |
| WO-2007066556-A1 | ORGANOMETALLIC COMPLEX AND LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE AND ELECTRONIC DEVICE USING THE SAME | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2007-06-14 | — | — | WO | disclosed |
| US-20070129545-A1 | Organometallic complex and light-emitting element, light-emitting device and electronic device using the same | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10103341-B2 | Organometallic complex and light emitting element, light emitting device, and electronic device using the organometallic complex | CRY1, AP1M1, AP2M1 | CCR5 2811/4885PARP1 1431/4885OPRK1 1206/4885 |
| US-20080312437-A1 | Organometallic Complex, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using the Organometallic Complex | NR2E3, AP2M1, AP3M1 | CCR5 2755/4885PARP1 1489/4885OPRK1 836/4885 |
| US-20170054093-A1 | Organometallic Complex, and Light-Emitting Element and Display Device Using the Organometallic Complex | NR2E3, TYR, LAGE3 | CCR5 3374/4885PARP1 4535/4885OPRK1 2529/4885 |
| US-20080160345-A1 | Organometallic complex, and light-emitting element, light-emitting device and electronic device including the organometallic compex | NR2E3, RBX1, MLX | CCR5 1035/4885PARP1 433/4885OPRK1 1952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.