Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.35 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.34 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282416 | 0.97 | TSHR (0.56) | TSHRTDP1ALDH1A1LMNAMAPT | |
| SCHEMBL11835178 | 0.94 | TSHR (0.53) | TSHRTDP1ALDH1A1LMNAMAPT | |
| SCHEMBL6061703 | 0.92 | TSHR (0.58) | TSHRTDP1ALDH1A1LMNAMAPT | |
| SCHEMBL1884965 | 0.89 | TSHR (0.63) | TSHRTDP1ALDH1A1LMNAMAPT | |
| SCHEMBL1879456 | 0.89 | TSHR (0.63) | TSHRTDP1ALDH1A1LMNAMAPT | |
| SCHEMBL7681688 | 0.89 | TSHR (0.55) | TSHRTDP1ALDH1A1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL11529395 | 0.89 | LMNA (0.61) | TSHRTDP1ALDH1A1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL11709847 | 0.89 | LMNA (0.61) | TSHRTDP1ALDH1A1LMNAMAPT | |
| SCHEMBL1885053 | 0.89 | TSHR (0.63) | TSHRTDP1ALDH1A1LMNAMAPT | |
| SCHEMBL6946256 | 0.89 | TSHR (0.55) | TSHRTDP1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160272606-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP | SANOFI (FR) | 2016-09-22 | — | — | US | disclosed |
| US-9382223-B2 | Process for preparation of dronedarone by oxidation of a hydroxyl group | SANOFI (FR) | 2016-07-05 | — | — | US | disclosed |
| US-20160009678-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP | SANOFI (FR) | 2016-01-14 | — | — | US | disclosed |
| US-8962869-B2 | Process for synthesizing keto benzofuran derivatives | SANOFI (FR) | 2015-02-24 | — | — | US | disclosed |
| US-8871956-B2 | Method for preparing 3-keto-benzofurane derivatives | SANOFI (FR) | 2014-10-28 | — | — | US | disclosed |
| US-8748636-B2 | Process for preparing benzofuran derivatives substituted at position 5 | SANOFI (FR) | 2014-06-10 | — | — | US | disclosed |
| US-20140046078-A1 | PROCESS FOR SYNTHESIZING KETO BENZOFURAN DERIVATIVES | SANOFI (FR) | 2014-02-13 | — | — | US | disclosed |
| US-20140018553-A1 | PROCESS FOR SYNTHESIZING KETO-BENZOFURAN DERIVATIVES | SANOFI (FR) | 2014-01-16 | — | — | US | disclosed |
| US-20130165673-A1 | METHOD FOR PREPARING 3-KETO-BENZOFURANE DERIVATIVES | SANOFI (FR) | 2013-06-27 | — | — | US | disclosed |
| US-20130165674-A1 | PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5 | SANOFI (FR) | 2013-06-27 | — | — | US | disclosed |
| CN-100371314-C | Benzoyl derivative and hydrochloride thereof and preparation method thereof | SANOFI SYNTHELABO (FR) | 2008-02-27 | — | — | CN | disclosed |
| CN-1295200-C | 2-butyl-3- (4- [3- (dibutylamino) propoxy ] benzoyl) -5-nitrobenzofuran hydrochloride and preparation thereof | SANOFI SYNTHELABO (FR) | 2007-01-17 | — | — | CN | disclosed |
| CN-1769262-A | Benzoyl derivative and hydrochloride thereof and preparation method thereof | SANOFI SYNTHELABO (FR) | 2006-05-10 | — | — | CN | disclosed |
| CN-1229366-C | Methanesulphonamido-benzofuran derivatives, process for their preparation and their use as synthesis intermediates | SANOFI SYNTHELABO (FR) | 2005-11-30 | — | — | CN | disclosed |
| US-6846936-B2 | 2-butyl-3-(4-[3(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof | SANOFI-SYNTHELABO (FR) | 2005-01-25 | — | — | US | disclosed |
| US-6828448-B2 | 2-butyl-5-(methanesulfonamido)benzofuran; preparation of dronedarone | SANOFI-SYNTHELABO (FR) | 2004-12-07 | — | — | US | disclosed |
| US-20040048921-A1 | Methanesulphonamido-benzofuran, preparation method and use thereof as synthesis intermediate | SANOFI (FR) | 2004-03-11 | — | — | US | disclosed |
| CN-1479735-A | Methanesulphonamido-benzofuran derivative, preparation method and use thereof as synthesis ntermediate | ʥŵ��-�ϳ�ʵ���ҹ�˾ | 2004-03-03 | — | — | CN | disclosed |
| CN-1479706-A | 2-butyl-3- (4- [ 3- (dibutylamino) propoxy ] benzoyl) -5-nitrobenzofuran hydrochloride and preparation thereof | ʥŵ��-�ϳ�ʵ���ҹ�˾ | 2004-03-03 | — | — | CN | disclosed |
| US-20040010032-A1 | 2-butyl-3-(4-[3(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof | SANOFI (FR) | 2004-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009678-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP | CYP2D6, CYP2B6, POR | GAA 1370/4885HTR1B 2852/4885KCNH2 288/4885 |
| US-20140046078-A1 | PROCESS FOR SYNTHESIZING KETO BENZOFURAN DERIVATIVES | CYP3A4, CYP2F1, DHPS | GAA 1967/4885HTR1B 3643/4885KCNH2 120/4885 |
| US-20130165673-A1 | METHOD FOR PREPARING 3-KETO-BENZOFURANE DERIVATIVES | CYP2F1, CBR3, STS | GAA 1736/4885HTR1B 4166/4885KCNH2 18/4885 |
| US-20130165674-A1 | PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5 | DHPS, SDHA, CYP2F1 | GAA 1309/4885HTR1B 1434/4885KCNH2 1303/4885 |
| US-20160272606-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP | CYP2D6, CYP2B6, POR | GAA 1329/4885HTR1B 2665/4885KCNH2 281/4885 |
| US-20040048921-A1 | Methanesulphonamido-benzofuran, preparation method and use thereof as synthesis intermediate | CYP2F1, DHPS, CYP2D6 | GAA 2281/4885HTR1B 1687/4885KCNH2 474/4885 |
| US-20040010032-A1 | 2-butyl-3-(4-[3(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof | CYP2D6, DBF4, DUT | GAA 2244/4885HTR1B 2550/4885KCNH2 217/4885 |
| US-20140018553-A1 | PROCESS FOR SYNTHESIZING KETO-BENZOFURAN DERIVATIVES | CYP2F1, CYP3A4, CYP2B6 | GAA 842/4885HTR1B 3909/4885KCNH2 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.