Hydrochloric Acid

Hydrochloric Acid

SCHEMBL720648

Cl.FC(F)(F)c1cccc(N2CCNCC2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 known ✓ Q99720 4/20 0.97
HTR3E known ✓ A5X5Y0 3/20 0.97
HTR3B known ✓ O95264 3/20 0.97
HTR3A known ✓ P46098 3/20 0.97
HTR3D known ✓ Q70Z44 3/20 0.97
HTR3C known ✓ Q8WXA8 3/20 0.97
HTR2C known ✓ P28335 2/20 0.97
HTR1D known ✓ P28221 1/20 0.97
ADRB1 known ✓ P08588 6/20 0.67
HTR1A known ✓ P08908 3/20 0.56
HTR7 known ✓ P34969 3/20 0.56
HTR2A known ✓ P28223 1/20 0.56
SLC6A4 known ✓ P31645 1/20 0.56
HTR2B known ✓ P41595 1/20 0.56
HTR6 known ✓ P50406 1/20 0.56
DRD2 known ✓ P14416 1/20 0.53
DRD3 known ✓ P35462 1/20 0.53
THRB P10828 2/20 1.00
MAPT P10636 1/20 1.00
ALDH1A1 P00352 4/20 0.97

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL12818335 1.00 THRB (1.00) THRBMAPTALDH1A1SIGMAR1HTR3E
Piperazine SCHEMBL28225297 0.98 THRB (0.97) THRBMAPTALDH1A1SIGMAR1HTR3E
SCHEMBL231692 0.98 ALDH1A1 (1.00) THRBMAPTALDH1A1SIGMAR1HTR3E
SCHEMBL6094745 0.98 ALDH1A1 (1.00) THRBMAPTALDH1A1SIGMAR1HTR3E
Bromide SCHEMBL9146763 0.97 ALDH1A1 (0.97) THRBMAPTALDH1A1SIGMAR1HTR3E
Hydrochloric Acid SCHEMBL9311165 0.94 THRB (0.88) THRBMAPTALDH1A1SIGMAR1HTR3E
SCHEMBL3060543 0.92 ALDH1A1 (0.88) THRBMAPTALDH1A1SIGMAR1HTR3E
SCHEMBL232665 0.89 ALDH1A1 (0.82) THRBMAPTALDH1A1SIGMAR1HTR3E
Hexane SCHEMBL6472819 0.88 ALDH1A1 (0.81) THRBMAPTALDH1A1SIGMAR1HTR3E
SCHEMBL31642192 0.87 HTR3E (0.79) THRBMAPTALDH1A1SIGMAR1HTR3E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107235913-B Method for efficiently manufacturing high-quality flibanserin on industrial scale 苏州科伦药物研究有限公司 2020-07-10 CN claimed
US-20120052682-A1 POLISHING SLURRY AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE USING THE SAME SAMSUNG ELECTRONICS CO., LTD. (KR) 2012-03-01 US claimed
EP-1611238-A4 GLUTAMATE TRANSPORT MODULATORY COMPOUNDS AND METHODS UNIV JOHNS HOPKINS (US) 2007-07-04 EP claimed
US-20060121488-A1 Glutamate transport modulatory compounds and methods NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2006-06-08 US claimed
EP-1611238-A2 GLUTAMATE TRANSPORT MODULATORY COMPOUNDS AND METHODS Johns Hopkins University (US) 2006-01-04 EP claimed
WO-2004076675-A2 GLUTAMATE TRANSPORT MODULATORY COMPOUNDS AND METHODS JOHNS HOPKINS UNIVERSITY (US) 2004-09-10 WO claimed
US-20260076975-A1 TPK AGONIST AND METHOD FOR USING SAME TO TREAT NEURODEGENERATIVE DISEASES SHANGHAI RAISING PHARMACEUTICAL CO LTD (CN) 2026-03-19 US disclosed
US-20250388584-A1 TPK AGONIST AND METHOD FOR TREATING NEURODEGENERATIVE DISEASES USING SAME SHANGHAI RAISING PHARMACEUTICAL CO LTD (CN) 2025-12-25 US disclosed
EP-4628098-A1 TPK AGONIST AND METHOD FOR USING SAME TO TREAT NEURODEGENERATIVE DISEASES Shanghai Raising Pharmaceutical Co., Ltd. (CN) 2025-10-08 EP disclosed
EP-4556007-A1 TPK AGONIST AND METHOD FOR TREATING NEURODEGENERATIVE DISEASES USING SAME Shanghai Raising Pharmaceutical Co., Ltd. (CN) 2025-05-21 EP disclosed
CN-119497615-A TPK agonists and methods of using the same for treating neurodegenerative diseases 上海日馨医药科技股份有限公司 2025-02-21 CN disclosed
WO-2024114781-A1 TPK AGONIST AND METHOD FOR USING SAME TO TREAT NEURODEGENERATIVE DISEASES 上海日馨医药科技股份有限公司 2024-06-06 WO disclosed
CN-118121699-A TPK agonists and methods of using the same for treating neurodegenerative diseases 上海日馨医药科技股份有限公司 2024-06-04 CN disclosed
EP-0117531-A1 N-(3-trifluoromethyl phenyl)-N'-propargyl piperazine, method for its preparation and its use BOEHRINGER INGELHEIM KG (DE) 1984-09-05 EP disclosed
EP-0025985-B1 2-SUBSTITUTED TRIAZOLO(4,3-1)PYRIDIN-3(2H)-ONES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DEPRESSION Bristol-Myers Company (US) 1983-11-23 EP disclosed
US-4271161-A ANALGESICS HEXACHIMIE (FR) 1981-06-02 US disclosed
EP-0027002-A1 1,2,4-Triazolo (4,3-a) quinolin-1 (2H)-ones and the compounds for use as pharmaceuticals Bristol-Myers Company (US) 1981-04-15 EP disclosed
EP-0025985-A1 2-Substituted triazolo(4,3-1)pyridin-3(2H)-ones, process for their preparation and pharmaceutical compositions for the treatment of depression Bristol-Myers Company (US) 1981-04-01 EP disclosed
US-4254124-A 2-(3-(4-(TRIFLUOROMETHYLPHENYL)-PIPERAZINO)-PROPYL)-S-TRIAZOLO(4,3 -A)PYRIDIN-3-ONE MEAD JOHNSON & COMPANY (US) 1981-03-03 US disclosed
US-4252806-A ANTIDEPRESSANTS MEAD JOHNSON & COMPANY (US) 1981-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260076975-A1 TPK AGONIST AND METHOD FOR USING SAME TO TREAT NEURODEGENERATIVE DISEASES PDXK, NADK, HYPK SIGMAR1 1334/4885HTR3E 1416/4885HTR3B 921/4885
US-20250388584-A1 TPK AGONIST AND METHOD FOR TREATING NEURODEGENERATIVE DISEASES USING SAME PDXK, SLC19A2, NADK SIGMAR1 1229/4885HTR3E 1021/4885HTR3B 471/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.