Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.52 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.50 |
| ▸ | TTR known ✓ | P02766 | 1/20 | 0.50 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.50 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.50 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.50 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.95 |
| ▸ | CES2 | O00748 | 1/20 | 0.65 |
| ▸ | CES1 | P23141 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.53 |
| ▸ | FEN1 | P39748 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29518925 | 0.97 | ALDH1A1 (1.00) | ALDH1A1CES2CES1TSHRALOX15 | |
| SCHEMBL29369803 | 0.97 | ALDH1A1 (1.00) | ALDH1A1CES2CES1TSHRALOX15 | |
| SCHEMBL29004189 | 0.97 | ALDH1A1 (1.00) | ALDH1A1CES2CES1TSHRALOX15 | |
| SCHEMBL367 | 0.97 | ALDH1A1 (1.00) | ALDH1A1CES2CES1TSHRALOX15 | |
| SCHEMBL8482425 | 0.97 | ALDH1A1 (1.00) | ALDH1A1CES2CES1TSHRALOX15 | |
| Hydrochloric Acid SCHEMBL28198869 | 0.95 | ALDH1A1 (0.86) | ALDH1A1CES2CES1TSHRALOX15 | |
| SCHEMBL11768054 | 0.95 | ALDH1A1 (0.95) | ALDH1A1CES2CES1TSHRALOX15 | |
| SCHEMBL6915337 | 0.95 | ALDH1A1 (0.95) | ALDH1A1CES2CES1TSHRALOX15 | |
| SCHEMBL8612015 | 0.95 | ALDH1A1 (0.95) | ALDH1A1CES2CES1TSHRALOX15 | |
| Fluoride SCHEMBL6444932 | 0.95 | ALDH1A1 (0.95) | ALDH1A1CES2CES1TSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210292264-A1 | Process for Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof | FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) | 2021-09-23 | — | — | US | claimed |
| EP-3713907-A1 | NEW PROCESS FOR MANUFACTURE OF FLUORINATED BENZENES AND FLUORINATED BENZOPHENONES, AND DERIVATIVES THEREOF | Fujian Yongjing Technology Co., Ltd (CN) | 2020-09-30 | — | — | EP | claimed |
| US-20200262776-A1 | New Process for the Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof | FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) | 2020-08-20 | — | — | US | claimed |
| WO-2020164291-A1 | NEW PROCESS FOR MANUFACTURE OF FLUORINATED BENZENES AND FLUORINATED BENZOPHENONES, AND DERIVATIVES THEREOF | FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) | 2020-08-20 | — | — | WO | claimed |
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-27 | — | — | US | disclosed |
| US-11465958-B2 | Process for Friedel-Crafts reaction, and catalyst therefore | FUJIAN YONGJING TECHNOLOGY CO., LTD. (CN) | 2022-10-11 | — | — | US | disclosed |
| US-20210292264-A1 | Process for Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof | FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) | 2021-09-23 | — | — | US | disclosed |
| CN-108430997-B | Microbicidal oxadiazole derivatives | 先正达参股股份有限公司 | 2021-06-04 | — | — | CN | disclosed |
| US-11008273-B2 | Process for the manufacture of fluorinated benzenes and fluorinated benzophenones, and derivatives thereof | FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) | 2021-05-18 | — | — | US | disclosed |
| US-20200262776-A1 | New Process for the Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof | FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) | 2020-08-20 | — | — | US | disclosed |
| US-20200262775-A1 | Process for Friedel-Crafts Reaction, and Catalyst Therefore | FUJIAN YONGJING TECHNOLOGY CO., LTD. (CN) | 2020-08-20 | — | — | US | disclosed |
| WO-2020164218-A1 | NEW PROCESS FOR FRIEDEL-CRAFTS REACTION, AND CATALYST THEREFORE | FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) | 2020-08-20 | — | — | WO | disclosed |
| US-4480030-A | BLOOD-COAGULATION FACTOR XA | PENTAPHARM A.G. (CH) | 1984-10-30 | — | — | US | disclosed |
| US-4440678-A | ARGININES | PENTAPHARM, A.G. (CH) | 1984-04-03 | — | — | US | disclosed |
| EP-0051828-B1 | N-BENZOYL-ALPHA-ANILINO ALKANE CARBOXYLIC ACIDS, SALTS AND ESTERS THEREOF, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | A. Nattermann & Cie. GmbH (DE) | 1984-03-14 | — | — | EP | disclosed |
| US-4388246-A | THERMAL SPLITTING OF CARBAMATES | BAYER AKTIENGESELLSCHAFT (DE) | 1983-06-14 | — | — | US | disclosed |
| US-4386031-A | ANTICOAGULANTS; ANTIALLERGENS; ANTINFLAM-MATORY AND ANTILIPEMIC AGENTS; ANTIHISTAMINES; CARDIOVASCULAR DISORDERS | A. NATTERMANN & CIE GMBH (DE) | 1983-05-31 | — | — | US | disclosed |
| EP-0051828-A1 | N-benzoyl-alpha-anilino alkane carboxylic acids, salts and esters thereof, process for producing the same and pharmaceutical preparations containing the same | A. Nattermann & Cie. GmbH (DE) | 1982-05-19 | — | — | EP | disclosed |
| US-4179436-A | DYEING POLYESTERS | BAYER AKTIENGESELLSCHAFT (DE) | 1979-12-18 | — | — | US | disclosed |
| US-4065458-A | VASODILATORS | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1977-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11008273-B2 | Process for the manufacture of fluorinated benzenes and fluorinated benzophenones, and derivatives thereof | PFAS, PFKFB4, PFKFB2 | CA2 4673/4885HDAC8 3606/4885TTR 4282/4885 |
| US-11465958-B2 | Process for Friedel-Crafts reaction, and catalyst therefore | HNF4A, TFEB, HACL2 | CA2 2745/4885HDAC8 2531/4885TTR 1669/4885 |
| US-20200262776-A1 | New Process for the Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof | PFAS, PFKFB4, PFKFB1 | CA2 4778/4885HDAC8 3609/4885TTR 4348/4885 |
| US-20210292264-A1 | Process for Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof | PFAS, PFKFB4, PFKFB2 | CA2 4757/4885HDAC8 3577/4885TTR 4250/4885 |
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | CFTR, PKD1, ARRB1 | CA2 2641/4885HDAC8 3279/4885TTR 3696/4885 |
| US-20200262775-A1 | Process for Friedel-Crafts Reaction, and Catalyst Therefore | HNF4A, TFEB, HACL2 | CA2 2745/4885HDAC8 2531/4885TTR 1669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.