Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3487781 | 0.90 | TSHR (0.43) | TSHRGABRA1GABRB2POLBALDH1A1 | |
| SCHEMBL30125051 | 0.89 | TSHR (0.38) | TSHRALDH1A1CYP3A4MAPTMEN1 | |
| SCHEMBL1552804 | 0.89 | TSHR (0.38) | TSHRALDH1A1CYP3A4MAPTMEN1 | |
| SCHEMBL9724609 | 0.80 | ESR1 (0.39) | TSHRCYP3A4MAPTLMNAGAA | |
| SCHEMBL10333062 | 0.78 | ALDH1A1 (0.42) | TSHRPOLBALDH1A1CYP3A4MAPT | |
| SCHEMBL387883 | 0.78 | ALDH1A1 (0.42) | TSHRPOLBALDH1A1CYP3A4MAPT | |
| SCHEMBL6681612 | 0.78 | LMNA (0.41) | TSHRMAPTMEN1KMT2ALMNA | |
| SCHEMBL27980950 | 0.76 | TSHR (0.46) | TSHRGABRA1GABRB2POLBCYP3A4 | |
| SCHEMBL29407501 | 0.76 | GABRA1 (0.62) | TSHRGABRA1GABRB2POLBALDH1A1 | |
| SCHEMBL78917 | 0.76 | GABRA1 (0.62) | TSHRGABRA1GABRB2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10406135-B2 | Compositions containing isosorbide monoester and alcohols that contain at least one aromatic group | CLARIANT INTERNATIONAL LTD. (CH) | 2019-09-10 | — | — | US | disclosed |
| US-9295626-B2 | Compositions comprising isosorbide monoester and N-hydroxypyridones | CLARIANT INTERNATIONAL LTD. (CH) | 2016-03-29 | — | — | US | disclosed |
| US-20160000080-A1 | COMPOSITIONS CONTAINING ISOSORBIDE MONOESTER AND ALIPHATIC VICINAL DIOLS | CLARIANT INTERNATIONAL LTD. (CH) | 2016-01-07 | — | — | US | disclosed |
| US-8962796-B2 | Modified variant Bowman Birk protease inhibitors | DANISCO US INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-20140369943-A1 | COMPOSITIONS COMPRISING ISOSORBIDE MONOESTERS AND HALOGENATED ANTIMICROBIAL ACTIVE COMPOUNDS | CLARIANT INTERNATIONAL LTD. (CH) | 2014-12-18 | — | — | US | disclosed |
| US-20140348763-A1 | COMPOSITIONS CONTAINING ISOSORBIDE MONOESTER AND ALCOHOLS THAT CONTAIN AT LEAST ONE AROMATIC GROUP | CLARIANT INTERNATIONAL LTD. (CH) | 2014-11-27 | — | — | US | disclosed |
| US-20140343171-A1 | COMPOSITIONS COMPRISING ISOSORBIDE MONOESTER AND N-HYDROXYPYRIDONES | CLARIANT INTERNATIONAL LTD. (CH) | 2014-11-20 | — | — | US | disclosed |
| US-20140329870-A1 | COMPOSITIONS COMPRISING ISOSORBIDE MONOESTERS AND ISOTHIAZOLINONES | CLARIANT INTERNATIONAL LTD. (CH) | 2014-11-06 | — | — | US | disclosed |
| US-20140308224-A1 | COSMETIC, DERMATOLOGICAL OR PHARMACEUTICAL COMPOSITIONS COMPRISING ISOSORBIDE DIESTERS AND UV FILTERS | CLARIANT INTERNATIONAL LTD. (CH) | 2014-10-16 | — | — | US | disclosed |
| US-8765103-B2 | Pearlescent pigments containing cosmetic compositions | GLASSFLAKE LIMITED (GB) | 2014-07-01 | — | — | US | disclosed |
| US-20080038213-A1 | Uv Filters | MERCK PATENT GMBH (DE) | 2008-02-14 | — | — | US | disclosed |
| US-20070196290-A1 | Uv filters in powder form | MERCK PATENT GMBH (DE) | 2007-08-23 | — | — | US | disclosed |
| US-20070191305-A1 | Chromone complexes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2007-08-16 | — | — | US | disclosed |
| US-20070155695-A1 | Flavonoid complexes with cyclodextrins | EUROPEAN BRAND PARTICIPATIONS SA (LU) | 2007-07-05 | — | — | US | disclosed |
| US-20060246149-A1 | Antimicrobial pigments | MERCK PATENT GMBH (DE) | 2006-11-02 | — | — | US | disclosed |
| US-20060210500-A1 | Formulations | MERCK PATENT GMBH (DE) | 2006-09-21 | — | — | US | disclosed |
| EP-1633818-A2 | ANTIMICROBIAL PIGMENTS | MERCK PATENT GmbH (DE) | 2006-03-15 | — | — | EP | disclosed |
| US-20050238679-A1 | Taurine-containing preparations for improving the skin barrier | BEIERSDORF AG (DE) | 2005-10-27 | — | — | US | disclosed |
| US-20050074471-A1 | Self-foaming or foamy preparations comprising particulate hydrophobic and/or hydrophobized and/or oil-absorbent solid substances | BEIERSDORF AG (DE) | 2005-04-07 | — | — | US | disclosed |
| WO-2004092283-A2 | ANTIMICROBIAL PIGMENTS | MERCK PATENT GMBH (DE) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050074471-A1 | Self-foaming or foamy preparations comprising particulate hydrophobic and/or hydrophobized and/or oil-absorbent solid substances | HBB, HBG1, FFAR1 | TSHR 2846/4885GABRA1 1053/4885GABRB2 991/4885 |
| US-20140308224-A1 | COSMETIC, DERMATOLOGICAL OR PHARMACEUTICAL COMPOSITIONS COMPRISING ISOSORBIDE DIESTERS AND UV FILTERS | POLR1C, CUTA, DEGS1 | TSHR 2901/4885GABRA1 209/4885GABRB2 69/4885 |
| US-20050238679-A1 | Taurine-containing preparations for improving the skin barrier | CETP, CUTA, SPTLC3 | TSHR 4020/4885GABRA1 4715/4885GABRB2 4777/4885 |
| US-20140348763-A1 | COMPOSITIONS CONTAINING ISOSORBIDE MONOESTER AND ALCOHOLS THAT CONTAIN AT LEAST ONE AROMATIC GROUP | ADH5, ADH1A, ADH1C | TSHR 3415/4885GABRA1 196/4885GABRB2 76/4885 |
| US-20160000080-A1 | COMPOSITIONS CONTAINING ISOSORBIDE MONOESTER AND ALIPHATIC VICINAL DIOLS | HSD17B12, DHCR7, ERG28 | TSHR 4673/4885GABRA1 391/4885GABRB2 119/4885 |
| US-20060246149-A1 | Antimicrobial pigments | LPO, TYR, CUTA | TSHR 1779/4885GABRA1 2841/4885GABRB2 4052/4885 |
| US-20070155695-A1 | Flavonoid complexes with cyclodextrins | TYR, DPM1, CYP2F1 | TSHR 4686/4885GABRA1 4395/4885GABRB2 3766/4885 |
| US-10406135-B2 | Compositions containing isosorbide monoester and alcohols that contain at least one aromatic group | ADH5, ADH1A, ADH1C | TSHR 3415/4885GABRA1 196/4885GABRB2 76/4885 |
| US-20140343171-A1 | COMPOSITIONS COMPRISING ISOSORBIDE MONOESTER AND N-HYDROXYPYRIDONES | HSD17B3, HSD3B1, HSD3B2 | TSHR 3430/4885GABRA1 526/4885GABRB2 362/4885 |
| US-20070191305-A1 | Chromone complexes | SCO2, CDYL, CYCS | TSHR 2687/4885GABRA1 4647/4885GABRB2 4710/4885 |
| US-20140369943-A1 | COMPOSITIONS COMPRISING ISOSORBIDE MONOESTERS AND HALOGENATED ANTIMICROBIAL ACTIVE COMPOUNDS | FASN, HSD17B12, ELOVL3 | TSHR 2333/4885GABRA1 590/4885GABRB2 237/4885 |
| US-20070196290-A1 | Uv filters in powder form | U2AF2, PRPF4, PRPF8 | TSHR 4448/4885GABRA1 2910/4885GABRB2 2861/4885 |
| US-20060210500-A1 | Formulations | TYR, SUCLG1, CYB5R3 | TSHR 3474/4885GABRA1 3878/4885GABRB2 4531/4885 |
| US-20080038213-A1 | Uv Filters | ERCC4, ERCC1, ERCC5 | TSHR 4476/4885GABRA1 2503/4885GABRB2 2597/4885 |
| US-20140329870-A1 | COMPOSITIONS COMPRISING ISOSORBIDE MONOESTERS AND ISOTHIAZOLINONES | HSD17B12, COASY, UGT2B17 | TSHR 2916/4885GABRA1 390/4885GABRB2 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.