Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Corynantheine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 9/20 | 1.00 |
| ▸ | ADRA1A known ✓ | P35348 | 8/20 | 1.00 |
| ▸ | ADRA2C known ✓ | P18825 | 6/20 | 1.00 |
| ▸ | ADRA2B known ✓ | P18089 | 5/20 | 1.00 |
| ▸ | ADRA1B known ✓ | P35368 | 4/20 | 1.00 |
| ▸ | HTR1B known ✓ | P28222 | 2/20 | 1.00 |
| ▸ | HTR6 known ✓ | P50406 | 2/20 | 1.00 |
| ▸ | BCHE known ✓ | P06276 | 1/20 | 1.00 |
| ▸ | HTR7 known ✓ | P34969 | 1/20 | 1.00 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 1.00 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 1.00 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.98 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.98 |
| ▸ | TOP1 known ✓ | P11387 | 2/20 | 0.98 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.98 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.98 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.98 |
| ▸ | HRH2 known ✓ | P25021 | 1/20 | 0.98 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.98 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rauwolscine SCHEMBL29473871 | 1.00 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA2BADRA1B | |
| Rauwolscine SCHEMBL4654130 | 1.00 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA2BADRA1B | |
| Rauwolscine SCHEMBL29353997 | 1.00 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA2BADRA1B | |
| Yohimbine SCHEMBL33955 | 1.00 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA2BADRA1B | |
| Yohimbine SCHEMBL8084613 | 1.00 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA2BADRA1B | |
| Rauwolscine SCHEMBL6515647 | 1.00 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA2BADRA1B | |
| Rauwolscine SCHEMBL4463142 | 1.00 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA2BADRA1B | |
| Rauwolscine SCHEMBL178033 | 1.00 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA2BADRA1B | |
| Rauwolscine SCHEMBL21433114 | 1.00 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA2BADRA1B | |
| Yohimbine SCHEMBL29354301 | 1.00 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA2BADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9982260-B2 | Identification of structurally similar small molecules that enhance therapeutic exon skipping | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-05-29 | — | — | US | claimed |
| US-20160257952-A1 | IDENTIFICATION OF STRUCTURALLY SIMILAR SMALL MOLECULES THAT ENHANCE THERAPEUTIC EXON SKIPPING | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-09-08 | — | — | US | claimed |
| US-11246873-B2 | Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-02-15 | — | — | US | disclosed |
| US-20200390780-A1 | DIRECTED DIFFERENTIATION OF OLIGODENDROCYTE PRECURSOR CELLS TO A MYELINATING CELL FATE | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2020-12-17 | — | — | US | disclosed |
| US-10660899-B2 | Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-05-26 | — | — | US | disclosed |
| US-10004701-B2 | Methods and compositions for treating infection | UNIVERSITY OF ROCHESTER (US) | 2018-06-26 | — | — | US | disclosed |
| US-9982260-B2 | Identification of structurally similar small molecules that enhance therapeutic exon skipping | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-05-29 | — | — | US | disclosed |
| US-9982260-B2 | Identification of structurally similar small molecules that enhance therapeutic exon skipping | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-05-29 | — | — | US | disclosed |
| US-9957484-B2 | Methods for promoting cell reprogramming | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2018-05-01 | — | — | US | disclosed |
| US-20170136029-A1 | DIRECTED DIFFERENTIATION OF OLIGODENDROCYTE PRECURSOR CELLS TO A MYELINATING CELL FATE | IRM LLC (BM) | 2017-05-18 | — | — | US | disclosed |
| US-9592288-B2 | Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-03-14 | — | — | US | disclosed |
| CN-103442705-A | Combination of syrosingopine and mitochondrial inhibitors for the treatment of cancer and immunosuppression | UNIV BASEL | 2013-12-11 | — | — | CN | disclosed |
| US-20130281478-A1 | COMBINATION OF SYROSINGOPINE AND MITOCHONDRIAL INHIBITORS FOR THE TREATMENT OF CANCER AND IMMUNOSUPPRESSION | UNIVERSITAT BASEL (CH) | 2013-10-24 | — | — | US | disclosed |
| US-20130064799-A1 | METHODS FOR PROMOTING CELL REPROGRAMMING | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2013-03-14 | — | — | US | disclosed |
| US-20130023488-A1 | METHODS AND COMPOUNDS FOR REDUCING INTRACELLULAR LIPID STORAGE | THE GENERAL HOSPITAL CORPORATION (US) | 2013-01-24 | — | — | US | disclosed |
| US-20120213746-A1 | METHOD AND COMPOUNDS FOR GENERATION OF iPSCs | Sanford Burnham Prebys Medical Discovery Institute | 2012-08-23 | — | — | US | disclosed |
| WO-2012112933-A1 | DIRECTED DIFFERENTIATION OF OLIGODENDROCYTE PRECURSOR CELLS TO A MYELINATING CELL FATE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-08-23 | — | — | WO | disclosed |
| EP-1910844-B1 | CROSS-BETA STRUCTURE BINDING COMPOUNDS | CROSSBETA BIOSCIENCES BV (NL) | 2012-04-18 | — | — | EP | disclosed |
| EP-2386861-A2 | Cross-ß structure binding compounds | Crossbeta Biosciences B.V. (NL) | 2011-11-16 | — | — | EP | disclosed |
| US-8041447-B2 | Numerical controller having workpiece setting error compensation means | FANUC LTD (JP) | 2011-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281478-A1 | COMBINATION OF SYROSINGOPINE AND MITOCHONDRIAL INHIBITORS FOR THE TREATMENT OF CANCER AND IMMUNOSUPPRESSION | SHMT2, MAVS, COX5A | ADRA2A 4570/4885ADRA1A 4627/4885ADRA2C 4692/4885 |
| US-10004701-B2 | Methods and compositions for treating infection | MMP8, IFNG, MPO | ADRA2A 4167/4885ADRA1A 4325/4885ADRA2C 3615/4885 |
| US-20130064799-A1 | METHODS FOR PROMOTING CELL REPROGRAMMING | HIPK2, HIPK3, HIPK1 | ADRA2A 4297/4885ADRA1A 4293/4885ADRA2C 4264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.