Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 3/20 | 0.41 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.37 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.37 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.34 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | GFER | P55789 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2266263 | 0.99 | MAPT (0.42) | MAPTGFERKDM4EGAARAD52 | |
| Iodide SCHEMBL2535919 | 0.97 | MAPT (0.41) | MAPTGFERKDM4EGAARAD52 | |
| Hydrochloric Acid SCHEMBL5924751 | 0.80 | MAPT (0.40) | MAPTGFERKDM4EGAARAD52 | |
| Hydrochloric Acid SCHEMBL2542731 | 0.79 | MAPT (0.41) | MAPTGFERKDM4EGAARAD52 | |
| SCHEMBL4627729 | 0.78 | MAPT (0.41) | MAPTGFERKDM4EGAARAD52 | |
| SCHEMBL2271837 | 0.78 | MAPT (0.43) | MAPTGFERKDM4EGAARAD52 | |
| SCHEMBL2267495 | 0.77 | MAPT (0.41) | MAPTGFERKDM4EGAARAD52 | |
| Bromide SCHEMBL2538004 | 0.77 | MAPT (0.42) | MAPTGFERKDM4EGAARAD52 | |
| SCHEMBL2272327 | 0.77 | MAPT (0.42) | MAPTGFERKDM4EGAARAD52 | |
| Iodide SCHEMBL2537438 | 0.77 | MAPT (0.42) | MAPTGFERKDM4EGAARAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8043385-B2 | Composition oxidation colouring of keratinic fibres, containing a cationic cellulose ether, a metasilicate and oxidation dyes, method for oxidation colouring and uses thereof | L'OREAL S.A. (FR) | 2011-10-25 | — | — | US | claimed |
| US-20100263138-A1 | COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF | L'OREAL S.A. (FR) | 2010-10-21 | — | — | US | claimed |
| EP-1428515-B1 | Dyeing composition comprising a tertiary paraphenylenediamine containing a pyrrolidine, and a surfactant; methods and uses | OREAL (FR) | 2008-07-02 | — | — | EP | claimed |
| US-20040250356-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a particular pearlescent or opacifying agent, methods and uses | L'OREAL (FR) | 2004-12-16 | — | — | US | claimed |
| US-20040226109-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a polyol, process therefor and use thereof | L'OREAL (FR) | 2004-11-18 | — | — | US | claimed |
| US-20040216243-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a surfactant, processes therefor and uses thereof | L'OREAL (FR) | 2004-11-04 | — | — | US | claimed |
| US-20040211010-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a polyol ester, processes therefor and uses thereof | L'OREAL (FR) | 2004-10-28 | — | — | US | claimed |
| US-20040205904-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a vitamin derivative, processes therefor and uses thereof | L'OREAL (FR) | 2004-10-21 | — | — | US | claimed |
| US-20040205903-A1 | Dyeing composition comprising a cationic pyrrolidine-based para-phenylenefiamine, a tertiary para-phenylenediamine and a benzomorpholine coupler, methods and uses | L'OREAL (FR) | 2004-10-21 | — | — | US | claimed |
| US-8043385-B2 | Composition oxidation colouring of keratinic fibres, containing a cationic cellulose ether, a metasilicate and oxidation dyes, method for oxidation colouring and uses thereof | L'OREAL S.A. (FR) | 2011-10-25 | — | — | US | disclosed |
| US-20040250356-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a particular pearlescent or opacifying agent, methods and uses | L'OREAL (FR) | 2004-12-16 | — | — | US | disclosed |
| US-20040231067-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and heterocyclic coupler, methods and uses | L'OREAL (FR) | 2004-11-25 | — | — | US | disclosed |
| US-20040231068-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a cationic polymer, methods and uses | L'OREAL (FR) | 2004-11-25 | — | — | US | disclosed |
| US-20040226109-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a polyol, process therefor and use thereof | L'OREAL (FR) | 2004-11-18 | — | — | US | disclosed |
| US-20040216244-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and an organic diacid, methods and uses | L'OREAL (FR) | 2004-11-04 | — | — | US | disclosed |
| US-20040216246-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a polymer containing a fatty chain, methods and uses | L'OREAL (FR) | 2004-11-04 | — | — | US | disclosed |
| US-20040216245-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a para-aminophenol, methods and uses | L'OREAL (FR) | 2004-11-04 | — | — | US | disclosed |
| US-20040211010-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a polyol ester, processes therefor and uses thereof | L'OREAL (FR) | 2004-10-28 | — | — | US | disclosed |
| US-20040205904-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a vitamin derivative, processes therefor and uses thereof | L'OREAL (FR) | 2004-10-21 | — | — | US | disclosed |
| US-20040205903-A1 | Dyeing composition comprising a cationic pyrrolidine-based para-phenylenefiamine, a tertiary para-phenylenediamine and a benzomorpholine coupler, methods and uses | L'OREAL (FR) | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040231068-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a cationic polymer, methods and uses | PHOSPHO1, KRT18, NUP205 | GAA 3349/4885ADRA2C 3644/4885ESR2 3896/4885 |
| US-20040205903-A1 | Dyeing composition comprising a cationic pyrrolidine-based para-phenylenefiamine, a tertiary para-phenylenediamine and a benzomorpholine coupler, methods and uses | CDC73, KRT18, PAH | GAA 4851/4885ADRA2C 1382/4885ESR2 2506/4885 |
| US-20040216246-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a polymer containing a fatty chain, methods and uses | KRT18, PLIN5, PLIN1 | GAA 4515/4885ADRA2C 3239/4885ESR2 3859/4885 |
| US-20040216245-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a para-aminophenol, methods and uses | KRT18, CDC73, NUP205 | GAA 4611/4885ADRA2C 3286/4885ESR2 3122/4885 |
| US-20040211010-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a polyol ester, processes therefor and uses thereof | KRT18, PPHLN1, PKLR | GAA 4341/4885ADRA2C 4569/4885ESR2 4274/4885 |
| US-20040250356-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and a particular pearlescent or opacifying agent, methods and uses | KRT18, CDC73, PPHLN1 | GAA 4764/4885ADRA2C 3909/4885ESR2 3842/4885 |
| US-20100263138-A1 | COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF | KRT18, TUBB3, VIM | GAA 4088/4885ADRA2C 3287/4885ESR2 3308/4885 |
| US-20040216243-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a surfactant, processes therefor and uses thereof | KRT18, NOTUM, PHOSPHO1 | GAA 3878/4885ADRA2C 3918/4885ESR2 4298/4885 |
| US-20040216244-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and an organic diacid, methods and uses | KRT18, CDC73, DDC | GAA 4540/4885ADRA2C 3724/4885ESR2 4091/4885 |
| US-20040226109-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a polyol, process therefor and use thereof | FARSB, PARN, PKLR | GAA 1898/4885ADRA2C 3556/4885ESR2 4744/4885 |
| US-20040205904-A1 | Dye composition comprising a cationic tertiary para-phenylenediamine and a vitamin derivative, processes therefor and uses thereof | KRT18, PPHLN1, PYCR1 | GAA 4705/4885ADRA2C 4557/4885ESR2 4578/4885 |
| US-20040231067-A1 | Dyeing composition comprising a cationic tertiary para-phenylenediamine and heterocyclic coupler, methods and uses | KRT18, CDC73, PYCR1 | GAA 4874/4885ADRA2C 4221/4885ESR2 3767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.