Hydrochloric Acid

Hydrochloric Acid

SCHEMBL3404095

COc1ccccc1N1CCN(CCCCOc2ccc3c(c2)NC(=O)CO3)CC1.Cl

nearest known ligand 0.98

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
DRD2 known ✓ P14416 12/20 0.98
HTR1A known ✓ P08908 2/20 0.98
HTR2A known ✓ P28223 2/20 0.98
HTR7 known ✓ P34969 1/20 0.71
HTR2B known ✓ P41595 1/20 0.71
HTR6 known ✓ P50406 1/20 0.71
DRD3 known ✓ P35462 7/20 0.71
DRD4 known ✓ P21917 6/20 0.71
SLC6A2 known ✓ P23975 1/20 0.61
SLC6A4 known ✓ P31645 1/20 0.61
ADRA1A known ✓ P35348 1/20 0.60
ALDH1A1 P00352 1/20 0.60
LMNA P02545 1/20 0.60
SMN1; SMN2 Q16637 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL31038578 1.00 DRD2 (0.98) DRD2HTR1AHTR2AHTR7HTR2B
SCHEMBL31038574 0.99 DRD2 (1.00) DRD2HTR1AHTR2AHTR7HTR2B
SCHEMBL3408535 0.99 DRD2 (1.00) DRD2HTR1AHTR2AHTR7HTR2B
SCHEMBL8160207 0.88 DRD2 (0.80) DRD2HTR1AHTR2AHTR7HTR2B
Hydrochloric Acid SCHEMBL4259307 0.86 DRD2 (0.73) DRD2HTR1AHTR2AHTR7HTR2B
SCHEMBL10865110 0.85 HTR1A (0.75) DRD2HTR1AHTR2AHTR2BSLC6A4
SCHEMBL4249939 0.85 DRD2 (0.74) DRD2HTR1AHTR2AHTR7HTR2B
Hydrochloric Acid SCHEMBL4254837 0.84 DRD2 (0.71) DRD2HTR1AHTR2AHTR7HTR2B
SCHEMBL8032044 0.84 DRD2 (0.74) DRD2HTR1AHTR2AHTR7HTR2B
Brilaroxazine SCHEMBL31038584 0.84 DRD2 (0.98) DRD2HTR1AHTR2AHTR7HTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9907803-B2 Methods for treating attention deficit hyperactivity disorder REVIVA PHARMACEUTICALS, INC. (US) 2018-03-06 US claimed
US-20170035772-A1 METHODS FOR TREATING ATTENTION DEFICIT HYPERACTIVITY DISORDER REVIVA PHARMACEUTICALS INC (US) 2017-02-09 US claimed
US-12053477-B2 Methods for treating pulmonary fibrosis REVIVA PHARMACEUTICALS, INC. (US) 2024-08-06 US disclosed
EP-3244896-B1 METHODS FOR TREATING PULMONARY HYPERTENSION REVIVA PHARMACEUTICALS INC (US) 2024-06-12 EP disclosed
US-20230061592-A1 METHODS FOR TREATING PULMONARY FIBROSIS REVIVA PHARMACEUTICALS, INC. 2023-03-02 US disclosed
US-20210128570-A1 METHODS FOR TREATING PULMONARY FIBROSIS REVIVA PHARMACEUTICALS INC (US) 2021-05-06 US disclosed
EP-3749324-A1 METHODS FOR TREATING PULMONARY FIBROSIS Reviva Pharmaceuticals Inc. (US) 2020-12-16 EP disclosed
US-10441590-B2 Methods for treating pulmonary hypertension REVIVA PHARMACEUTICALS, INC. (US) 2019-10-15 US disclosed
US-9975862-B2 Arylpiperazine derivatives and methods of utilizing same REVIVA PHARMACEUTICALS, INC. (US) 2018-05-22 US disclosed
US-20180125851-A1 METHODS FOR TREATING PULMONARY HYPERTENSION REVIVA PHARMACEUTICALS, INC. 2018-05-10 US disclosed
US-9907803-B2 Methods for treating attention deficit hyperactivity disorder REVIVA PHARMACEUTICALS, INC. (US) 2018-03-06 US disclosed
US-20150005298-A1 ARYLPIPERAZINE DERIVATIVES AND METHODS OF UTILIZING SAME REVIVA PHARMACEUTICALS INC (US) 2015-01-01 US disclosed
US-8859552-B2 Methods of utilizing arylpiperazine derivatives REVIVA PHARMACEUTICALS, INC. (US) 2014-10-14 US disclosed
US-20140155392-A1 METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES REVIVA PHARMACEUTICALS, INC. (US) 2014-06-05 US disclosed
US-8461154-B2 Methods of utilizing arylpiperazine derivatives REVIVA PHARMACEUTICALS, INC. (US) 2013-06-11 US disclosed
US-8431570-B2 Methods of utilizing arylpiperazine derivatives REVIVA PHARMACEUTICALS, INC. (US) 2013-04-30 US disclosed
US-20120220579-A1 METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES BHAT LAXMINARAYAN (US) 2012-08-30 US disclosed
US-20120220574-A1 METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES BHAT LAXMINARAYAN (US) 2012-08-30 US disclosed
US-8188076-B2 Compositions, synthesis, and methods of utilizing arylpiperazine derivatives REVIVA PHARMACEUTICALS, INC. (US) 2012-05-29 US disclosed
US-20100216783-A1 COMPOSITIONS, SYNTHESIS, AND METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES REVIVA PHARMACEUTICALS, INC. 2010-08-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210128570-A1 METHODS FOR TREATING PULMONARY FIBROSIS MMP1, CCL11, PAH DRD2 4417/4885HTR1A 1544/4885HTR2A 1984/4885
US-20180125851-A1 METHODS FOR TREATING PULMONARY HYPERTENSION CYP11B2, PAH, CYP11B1 DRD2 3542/4885HTR1A 453/4885HTR2A 541/4885
US-20150005298-A1 ARYLPIPERAZINE DERIVATIVES AND METHODS OF UTILIZING SAME GRIK5, HTR5A, HTR2A DRD2 10/4885HTR1A 32/4885HTR2A 3/4885
US-20120220579-A1 METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES HTR5A, GRIK5, HTR2A DRD2 14/4885HTR1A 22/4885HTR2A 3/4885
US-20120220574-A1 METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES HTR5A, GRIK5, HTR2A DRD2 14/4885HTR1A 22/4885HTR2A 3/4885
US-20140155392-A1 METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES HTR5A, GRIK5, HTR2A DRD2 14/4885HTR1A 22/4885HTR2A 3/4885
US-20230061592-A1 METHODS FOR TREATING PULMONARY FIBROSIS MMP1, CCL11, PAH DRD2 4417/4885HTR1A 1544/4885HTR2A 1984/4885
US-12053477-B2 Methods for treating pulmonary fibrosis MMP1, CCL11, PAH DRD2 4417/4885HTR1A 1544/4885HTR2A 1984/4885
US-20170035772-A1 METHODS FOR TREATING ATTENTION DEFICIT HYPERACTIVITY DISORDER HTR2C, SLC6A2, HTR5A DRD2 36/4885HTR1A 12/4885HTR2A 6/4885
US-20100216783-A1 COMPOSITIONS, SYNTHESIS, AND METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES GRIK5, HTR5A, KYNU DRD2 18/4885HTR1A 33/4885HTR2A 5/4885
US-10441590-B2 Methods for treating pulmonary hypertension CYP11B2, PAH, CYP11B1 DRD2 3542/4885HTR1A 453/4885HTR2A 541/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.