Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A known ✓ | Q14524 | 2/20 | 0.56 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.56 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.56 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.56 |
| ▸ | HRH2 known ✓ | P25021 | 1/20 | 0.56 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.56 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.56 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.56 |
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.56 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.56 |
| ▸ | SCN7A known ✓ | Q01118 | 1/20 | 0.56 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.56 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.56 |
| ▸ | SCN9A known ✓ | Q15858 | 1/20 | 0.56 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.56 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.56 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.56 |
| ▸ | SCN8A known ✓ | Q9UQD0 | 1/20 | 0.56 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL510069 | 1.00 | LMNA (0.58) | LMNARAB9AKDM4EGMNNBLM | |
| SCHEMBL29020376 | 0.85 | LMNA (0.59) | LMNARAB9AKDM4EGMNNBLM | |
| Butane SCHEMBL6810096 | 0.83 | RAB9A (0.56) | LMNARAB9AKDM4EGMNNBLM | |
| SCHEMBL5925590 | 0.82 | ALDH1A1 (0.44) | LMNARAB9AKDM4EMAPK1TSHR | |
| Butane SCHEMBL21438842 | 0.81 | LMNA (0.55) | LMNARAB9AKDM4EGMNNBLM | |
| SCHEMBL1118828 | 0.81 | ALDH1A1 (0.43) | LMNARAB9AKDM4EBLMMAPK1 | |
| SCHEMBL5925519 | 0.80 | HSD17B10 (0.55) | LMNARAB9AKDM4EBLMCYP1A2 | |
| SCHEMBL14149520 | 0.78 | SCN5A (0.68) | LMNARAB9AKDM4EGMNNBLM | |
| Hydrochloric Acid SCHEMBL11345886 | 0.77 | LMNA (0.50) | LMNARAB9AKDM4EGMNNBLM | |
| SCHEMBL11341345 | 0.76 | LMNA (0.50) | LMNARAB9AKDM4EGMNNBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120029167-A1 | AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND | YOSHIHIRO ISHIKAWA (JP) | 2012-02-02 | — | — | US | claimed |
| EP-2357166-A1 | AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND | IHI Corporation (JP) | 2011-08-17 | — | — | EP | claimed |
| CN-119095642-A | Locally applicable system | 考司美德制药株式会社 | 2024-12-06 | — | — | CN | disclosed |
| CN-112672738-A | Pharmaceutical composition | 小林制药株式会社 | 2021-04-16 | — | — | CN | disclosed |
| EP-3705155-A1 | DENTAL LOCAL ANESTHETIC MICRONEEDLE ARRAY | Cosmed Pharmaceutical Co., Ltd. (JP) | 2020-09-09 | — | — | EP | disclosed |
| US-9505732-B2 | Auto magnetic metal salen complex compound | IHI CORPORATION (JP) | 2016-11-29 | — | — | US | disclosed |
| US-9034843-B2 | Ophthalmic composition | ROHTO PHARMACEUTICAL CO., LTD. (JP) | 2015-05-19 | — | — | US | disclosed |
| US-8754029-B2 | Ophthalmic composition | ROHTO PHARMACEUTICAL CO., LTD. (JP) | 2014-06-17 | — | — | US | disclosed |
| US-20130244978-A1 | OPHTHALMIC COMPOSITION | ROHTO PHARMACEUTICAL CO., LTD. (JP) | 2013-09-19 | — | — | US | disclosed |
| US-20130102977-A1 | OPHTHALMIC COMPOSITION | ROHTO PHARMACEUTICAL CO., LTD. (JP) | 2013-04-25 | — | — | US | disclosed |
| CN-101854939-B | Ophthalmic composition | ROHTO PHARMA | 2012-10-24 | — | — | CN | disclosed |
| US-20120029167-A1 | AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND | YOSHIHIRO ISHIKAWA (JP) | 2012-02-02 | — | — | US | disclosed |
| US-20110223126-A1 | OPHTHALMIC COMPOSITION | MATSUMURA YASUKO | 2011-09-15 | — | — | US | disclosed |
| EP-2357166-A1 | AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND | IHI Corporation (JP) | 2011-08-17 | — | — | EP | disclosed |
| CN-101854939-A | Ophthalmic composition | ROHTO PHARMA | 2010-10-06 | — | — | CN | disclosed |
| US-20100249062-A1 | OPHTHALMIC COMPOSITION | ROHTO PHARMACEUTICAL CO., LTD. (JP) | 2010-09-30 | — | — | US | disclosed |
| US-20100239518-A1 | OPHTHALMIC COMPOSITION | ROHTO PHARMACEUTICAL CO., LTD. (JP) | 2010-09-23 | — | — | US | disclosed |
| US-20100216741-A1 | OPHTHALMIC COMPOSITION | ROHTO PHARMACEUTICAL CO., LTD. (JP) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029167-A1 | AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND | SDHB, SDHA, SLC40A1 | SCN5A 524/4885MAOA 73/4885DRD4 3807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.