4-Methylbenzoic Acid

4-Methylbenzoic Acid

SCHEMBL902358

Cc1ccc(C(=O)O)cc1.Cl

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of 4-Methylbenzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 known ✓ P00918 2/20 0.55
DRD1 known ✓ P21728 1/20 0.55
GAA known ✓ P10253 1/20 0.54
HDAC1 known ✓ Q13547 1/20 0.52
HDAC6 known ✓ Q9UBN7 1/20 0.52
ALDH1A1 P00352 5/20 0.94
SMN1; SMN2 Q16637 2/20 0.94
SRD5A2 P31213 3/20 0.81
TSHR P16473 3/20 0.67
TP53 P04637 1/20 0.67
CES2 O00748 2/20 0.62
CES1 P23141 2/20 0.62
LMNA P02545 2/20 0.62
RXRA P19793 1/20 0.58
RXRB P28702 1/20 0.58
CA1 P00915 2/20 0.55
CA12 O43570 1/20 0.55
CA3 P07451 1/20 0.55
TYR P14679 1/20 0.55
CA4 P22748 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Methylbenzoic Acid SCHEMBL28013046 0.97 ALDH1A1 (0.90) ALDH1A1SMN1; SMN2SRD5A2TSHRTP53
4-Methylbenzoic Acid SCHEMBL11366477 0.97 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2SRD5A2TSHRTP53
Terephthalic Acid SCHEMBL526449 0.97 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2SRD5A2TSHRTP53
4-Methylbenzoic Acid SCHEMBL147465 0.97 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2SRD5A2TSHRTP53
Terephthalic Acid SCHEMBL15994097 0.97 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2SRD5A2TSHRTP53
4-Methylbenzoic Acid SCHEMBL1331178 0.97 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2SRD5A2TSHRTP53
4-Methylbenzoic Acid SCHEMBL93638 0.97 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2SRD5A2TSHRTP53
4-Methylbenzoic Acid SCHEMBL27860985 0.95 ALDH1A1 (0.85) ALDH1A1SMN1; SMN2SRD5A2TSHRTP53
4-Methylbenzoic Acid SCHEMBL28297064 0.95 ALDH1A1 (0.85) ALDH1A1SMN1; SMN2SRD5A2TSHRTP53
4-Methylbenzoic Acid SCHEMBL1150904 0.94 ALDH1A1 (0.94) ALDH1A1SMN1; SMN2SRD5A2TSHRTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2621891-A1 POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYLBENZOATE HYDROCHLORIDE, METHODS FOR PREPARING THE SAME AND USE OF THE SAME Shan Dong Luye Pharmaceutical Co., Ltd. (CN) 2013-08-07 EP claimed
WO-2012041013-A1 POLYMORPHS OF 4-[2-DIMETHYLAMINO-1-(1-HYDROXYCYCLOHEXYL)ETHYL]PHENYL 4-METHYLBENZOATE HYDROCHLORIDE, METHODS FOR PREPARING THE SAME AND USE OF THE SAME SHAN DONG LUYE PHARMACEUTICAL CO., LTD. (CN) 2012-04-05 WO claimed
EP-3921349-B1 PHENYL ISOCYANATE CONVERSION PROCESS DOW GLOBAL TECHNOLOGIES LLC (US) 2026-01-14 EP disclosed
EP-3689849-B1 PERFUME PRECURSOR TAKASAGO PERFUMERY CO LTD (JP) 2025-01-15 EP disclosed
US-12030836-B2 Phenyl isocyanate conversion process DOW GLOBAL TECHNOLOGIES LLC (US) 2024-07-09 US disclosed
CN-113474388-B Method for converting phenyl isocyanate 陶氏环球技术有限责任公司 2024-03-22 CN disclosed
US-11802258-B2 Perfume precursor TAKASAGO INTERNATIONAL CORPORATION (JP) 2023-10-31 US disclosed
WO-2022091938-A1 METHOD FOR PRODUCING SOLID CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, METHOD FOR PRODUCING CATALYST FOR OLEFIN POLYMERIZATION, AND METHOD FOR PRODUCING OLEFIN POLYMER 東邦チタニウム株式会社 2022-05-05 WO disclosed
US-11306053-B2 Ester compound and lubricating oil base oil DAISAN KASEI CO., LTD (JP) 2022-04-19 US disclosed
US-20220106264-A1 PHENYL ISOCYANATE CONVERSION PROCESS DOW GLOBAL TECHNOLOGIES LLC 2022-04-07 US disclosed
EP-3921349-A1 PHENYL ISOCYANATE CONVERSION PROCESS Dow Global Technologies LLC (US) 2021-12-15 EP disclosed
US-4329456-A ACYLATION WITHOUT INTERMEDIATE ISOLATION CIBA-GEIGY AG (CH) 1982-05-11 US disclosed
EP-0044635-A1 Catalyst components for polymerization of alpha-olefins and a method for using them TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) 1982-01-27 EP disclosed
US-4294777-A ADDING AN ALDEHYDE, KETONE, OLEFIN, ORGANOPHOSPHORUS OR ORGANOARSENIC COMPOUND BAYER AKTIENGESELLSCHAFT (DE) 1981-10-13 US disclosed
US-4179436-A DYEING POLYESTERS BAYER AKTIENGESELLSCHAFT (DE) 1979-12-18 US disclosed
US-4135045-A PROCESS FOR POLYMERIZATION OF OLEFINS AND CATALYST COMPOSITION THEREFOR MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1979-01-16 US disclosed
US-4120884-A Storage-stable, liquid polyisocyanates possessing carbodiimide groups, and process for their manufacture BASF AKTIENGESELLSCHAFT (DE) 1978-10-17 US disclosed
US-4048415-A TITANIUM-ALUMINUM COORDINATION CATALYSTS MITSUI PETROCHEMICAL INDUSTRIES LTD. (JA) 1977-09-13 US disclosed
US-4001426-A HAVING CORONARY VASODILATOR ACTIVITY SMITHKLINE CORPORATION (US) 1977-01-04 US disclosed
US-3996210-A OPTICAL BRIGHTENERS SANDOZ LTD. (CH) 1976-12-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11306053-B2 Ester compound and lubricating oil base oil F12, ELOVL1, HRH1 CA2 3488/4885DRD1 490/4885GAA 4393/4885
US-11802258-B2 Perfume precursor CYP2E1, ADH1A, CYP1A1 CA2 3624/4885DRD1 256/4885GAA 4538/4885
US-12030836-B2 Phenyl isocyanate conversion process UROD, HPD, UBE2I CA2 3133/4885DRD1 37/4885GAA 3967/4885
US-20220106264-A1 PHENYL ISOCYANATE CONVERSION PROCESS UROD, HPD, UBE2I CA2 3133/4885DRD1 37/4885GAA 3967/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.