Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.35 |
| ▸ | PPARG known ✓ | P37231 | 6/20 | 0.33 |
| ▸ | HDAC11 known ✓ | Q96DB2 | 5/20 | 0.33 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.33 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.33 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 3/20 | 0.36 |
| ▸ | FAAH | O00519 | 4/20 | 0.36 |
| ▸ | CES1 | P23141 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988084 | 0.98 | HSD17B10 (0.41) | HSD17B10GMNNTP53POLBMAPT | |
| Ethylene SCHEMBL31337284 | 0.95 | HSD17B10 (0.39) | HSD17B10GMNNTP53POLBMAPT | |
| Methoxymethane SCHEMBL30701424 | 0.94 | HSD17B10 (0.38) | HSD17B10GMNNTP53POLBMAPT | |
| SCHEMBL13730363 | 0.92 | ALDH1A1 (0.39) | HSD17B10GMNNTP53POLBMAPT | |
| SCHEMBL17764215 | 0.91 | BLM (0.36) | HSD17B10GMNNTP53POLBMAPT | |
| SCHEMBL17642262 | 0.85 | CES2 (0.41) | HSD17B10GMNNTP53POLBMAPT | |
| SCHEMBL10030122 | 0.84 | ALDH1A1 (0.41) | ALDH1A1HDAC11TSHRTDP1 | |
| SCHEMBL17556646 | 0.84 | ALDH1A1 (0.34) | HSD17B10GMNNTP53POLBMAPT | |
| SCHEMBL1249046 | 0.84 | ALDH1A1 (0.36) | HSD17B10GMNNTP53POLBMAPT | |
| SCHEMBL22092414 | 0.83 | HSD17B10 (0.42) | HSD17B10GMNNTP53POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11707483-B2 | Micellic assemblies | UNIVERSITY OF WASHINGTON (US) | 2023-07-25 | — | — | US | disclosed |
| US-20200147121-A1 | MICELLIC ASSEMBLIES | UNIVERSITY OF WASHINGTON (US) | 2020-05-14 | — | — | US | disclosed |
| US-9662403-B2 | Micellic assemblies | UNIVERSITY OF WASHINGTON (US) | 2017-05-30 | — | — | US | disclosed |
| US-20160250338-A1 | MICELLIC ASSEMBLIES | UNIVERSITY OF WASHINGTON (US) | 2016-09-01 | — | — | US | disclosed |
| US-9339558-B2 | Micellic assemblies | UNIVERSITY OF WASHINGTON (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150238619-A1 | POLYMERIC CARRIER | PHASERX, INC. (US) | 2015-08-27 | — | — | US | disclosed |
| US-9006193-B2 | Polymeric carrier | UNIVERSITY OF WASHINGTON (US) | 2015-04-14 | — | — | US | disclosed |
| EP-2285853-B1 | MICELLIC ASSEMBLIES | UNIV WASHINGTON (US) | 2013-02-27 | — | — | EP | disclosed |
| US-20110142951-A1 | MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS | UNIVERSITY OF WASHINGTON (US) | 2011-06-16 | — | — | US | disclosed |
| US-20110143435-A1 | POLYMERIC CARRIER | UNIVERSITY OF WASHINGTON (US) | 2011-06-16 | — | — | US | disclosed |
| US-20110123636-A1 | MICELLIC ASSEMBLIES | UNIVERSITY OF WASHINGTON (US) | 2011-05-26 | — | — | US | disclosed |
| EP-2296627-A2 | MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS | The University of Washington (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2296708-A2 | POLYMERIC CARRIER | University of Washington (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2285853-A2 | MICELLIC ASSEMBLIES | University of Washington (US) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009140432-A2 | MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS | UNIVERSITY OF WASHINGTON (US) | 2009-11-19 | — | — | WO | disclosed |
| WO-2009140429-A2 | MICELLIC ASSEMBLIES | UNIVERSITY OF WASHINGTON (US) | 2009-11-19 | — | — | WO | disclosed |
| WO-2009140421-A2 | POLYMERIC CARRIER | UNIVERSITY OF WASHINGTON (US) | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11707483-B2 | Micellic assemblies | UACA, CLPTM1L, BPHL | ACHE 895/4885PPARG 4750/4885HDAC11 4227/4885 |
| US-20160250338-A1 | MICELLIC ASSEMBLIES | CLPX, VCL, ANXA5 | ACHE 2259/4885PPARG 4674/4885HDAC11 4539/4885 |
| US-20200147121-A1 | MICELLIC ASSEMBLIES | CLPX, VCL, ANXA5 | ACHE 2259/4885PPARG 4674/4885HDAC11 4539/4885 |
| US-20110142951-A1 | MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS | ACTB, MTHFD1, SSBP1 | ACHE 4783/4885PPARG 4027/4885HDAC11 3538/4885 |
| US-20110123636-A1 | MICELLIC ASSEMBLIES | CLPX, VCL, ANXA5 | ACHE 2259/4885PPARG 4674/4885HDAC11 4539/4885 |
| US-20150238619-A1 | POLYMERIC CARRIER | POLI, DCLRE1B, POLRMT | ACHE 4866/4885PPARG 4125/4885HDAC11 2369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.