Hydrochloric Acid

Hydrochloric Acid

SCHEMBL271876

C1CC2COCC(C1)N2.Cl

nearest known ligand 0.31

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP2C9 P11712 1/20 0.30
TSHR P16473 1/20 0.30
CYP2C19 P33261 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL30926986 1.00 KDM4E (0.31) KDM4EALDH1A1CYP2C9TSHRCYP2C19
Hydrochloric Acid SCHEMBL17560231 0.97 KDM4E (0.30) KDM4EALDH1A1
SCHEMBL272458 0.97
SCHEMBL15366209 0.97
Bromide SCHEMBL7941597 0.94 KDM4E (0.31) KDM4EALDH1A1CYP2C9TSHRCYP2C19
Methyl Alcohol SCHEMBL26106863 0.92 KDM4E (0.36) KDM4EALDH1A1CYP2C9TSHRCYP2C19
SCHEMBL23505786 0.91
Hydrochloric Acid SCHEMBL2257363 0.88
Hydrochloric Acid SCHEMBL21121551 0.88
Hydrochloric Acid SCHEMBL18386 0.88

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062419-A1 TREATMENT OF SKIN DISORDERS TORQUR AG (CH) 2026-03-05 US disclosed
US-12497407-B2 Treatment of skin disorders TORQUR AG (CH) 2025-12-16 US disclosed
US-20250214998-A1 CYCLIC COMPOUNDS AS RECEPTOR MODULATING THERAPEUTICS AND METHODS AND USES THEREOF BIONOMICS LTD (AU) 2025-07-03 US disclosed
US-12275732-B2 Cyclic compounds as receptor modulating therapeutics and methods and uses thereof BIONOMICS LIMITED (AU) 2025-04-15 US disclosed
US-20240382496-A1 TREATMENT OF SKIN LESIONS TORQUR AG (CH) 2024-11-21 US disclosed
CN-115768769-B Tetrahydroisoquinoline compound and application thereof 南京再明医药有限公司 2024-10-22 CN disclosed
US-20240343718-A1 TREATMENT OF NEUROLOGICAL DISORDERS TORQUR AG (CH) 2024-10-17 US disclosed
WO-2024183629-A1 USE OF 3CLPRO INHIBITOR IN PREPARATION OF DRUG FOR TREATING DISEASES CAUSED BY FELINE CORONAVIRUS 齐鲁动物保健品有限公司 2024-09-12 WO disclosed
US-20240101549-A1 N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-QUINOLINE-4-CARBOXAMIDES ASTRAZENECA AB (SE) 2024-03-28 US disclosed
US-11918586-B2 Treatment of skin lesions TORQUR AG (CH) 2024-03-05 US disclosed
US-20090023717-A1 MORPHINE-BRIDGED INDAZOLE DERIVATIVES FEURER ACHIM 2009-01-22 US disclosed
US-7427617-B2 Morpoline-bridged indazole derivatives BAYER HEALTHCARE AG (DE) 2008-09-23 US disclosed
US-20080226591-A1 Compounds for the Treatment of Hepatitis C BRISTOL-MYERS SQUIBB COMPANY 2008-09-18 US disclosed
WO-2008112848-A1 COMPOUNDS FOR THE TREATMENT OF HEPATITIS C BRISTOL-MYERS SQUIBB COMPANY (US) 2008-09-18 WO disclosed
US-20060128700-A1 e.g. 2-[1-(2-Fluorobenzyl)-1H-indazol-3-yl]-5-(3-oxa-9-azabicyclo[3.3.1]non-9-yl)-4pyrimidinylamine; soluble guanylate cyclase stimulant; neurodegenerative diseases, cognition activator; Alhzeimer's, Parkinson's disease, Pick's syndrome, multiple sclerosis, HIV dementia, schizophrenia BAYER HEALTHCARE AG (DE) 2006-06-15 US disclosed
EP-1546147-A1 MORPHOLINE-BRIDGED INDAZOLE DERIVATIVES Bayer HealthCare AG (DE) 2005-06-29 EP disclosed
US-20040235863-A1 Morpholine-bridged pyrazolopyridine derivatives BAYER HEALTHCARE AG (DE) 2004-11-25 US disclosed
WO-2004031186-A1 MORPHOLINE-BRIDGED INDAZOLE DERIVATIVES BAYER HEALTHCARE AG (DE) 2004-04-15 WO disclosed
EP-1406908-A1 MORPHOLINE-BRIDGED PYRAZOLOPYRIDINE DERIVATIVES Bayer HealthCare AG (DE) 2004-04-14 EP disclosed
WO-2003004503-A1 MORPHOLINE-BRIDGED PYRAZOLOPYRIDINE DERIVATIVES BAYER HEALTHCARE AG (DE) 2003-01-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090023717-A1 MORPHINE-BRIDGED INDAZOLE DERIVATIVES OPRM1, OPRK1, OPRD1 KDM4E 2881/4885ALDH1A1 1430/4885CYP2C9 695/4885
US-20240382496-A1 TREATMENT OF SKIN LESIONS C1R, C3AR1, CXCR3 KDM4E 3943/4885ALDH1A1 3993/4885CYP2C9 166/4885
US-20260062419-A1 TREATMENT OF SKIN DISORDERS POLR1C, CCR1, COL1A1 KDM4E 3261/4885ALDH1A1 1855/4885CYP2C9 1784/4885
US-20250214998-A1 CYCLIC COMPOUNDS AS RECEPTOR MODULATING THERAPEUTICS AND METHODS AND USES THEREOF CHRNA7, CHRNA5, CHRNA1 KDM4E 3575/4885ALDH1A1 836/4885CYP2C9 1995/4885
US-20240343718-A1 TREATMENT OF NEUROLOGICAL DISORDERS CHRM2, CHRM1, C1R KDM4E 4124/4885ALDH1A1 3642/4885CYP2C9 160/4885
US-12275732-B2 Cyclic compounds as receptor modulating therapeutics and methods and uses thereof CHRNA7, CHRNA1, CHRNA5 KDM4E 3556/4885ALDH1A1 832/4885CYP2C9 1938/4885
US-20060128700-A1 e.g. 2-[1-(2-Fluorobenzyl)-1H-indazol-3-yl]-5-(3-oxa-9-azabicyclo[3.3.1]non-9-yl)-4pyrimidinylamine; soluble guanylate cyclase stimulant; neurodegenerative diseases, cognition activator; Alhzeimer's, Parkinson's disease, Pick's syndrome, multiple sclerosis, HIV dementia, schizophrenia GUCY1B2, COG4, GUCY1A2 KDM4E 1499/4885ALDH1A1 3891/4885CYP2C9 4352/4885
US-12497407-B2 Treatment of skin disorders RXFP3, CCR3, CBR3 KDM4E 3977/4885ALDH1A1 3917/4885CYP2C9 667/4885
US-11918586-B2 Treatment of skin lesions C1R, C3AR1, CXCR3 KDM4E 3943/4885ALDH1A1 3993/4885CYP2C9 166/4885
US-20240101549-A1 N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-QUINOLINE-4-CARBOXAMIDES FAP, PREP, CTRL KDM4E 895/4885ALDH1A1 1593/4885CYP2C9 1963/4885
US-20040235863-A1 Morpholine-bridged pyrazolopyridine derivatives GUCY1A1, PDE1A, PDE3B KDM4E 4394/4885ALDH1A1 1862/4885CYP2C9 2943/4885
US-20080226591-A1 Compounds for the Treatment of Hepatitis C HAVCR2, HCCS, SLC10A1 KDM4E 3736/4885ALDH1A1 163/4885CYP2C9 345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.