Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F known ✓ | O60840 | 2/20 | 0.33 |
| ▸ | OPRK1 known ✓ | P41145 | 2/20 | 0.33 |
| ▸ | CACNA1D known ✓ | Q01668 | 2/20 | 0.33 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.33 |
| ▸ | CACNA1S known ✓ | Q13698 | 2/20 | 0.33 |
| ▸ | CACNA1C known ✓ | Q13936 | 2/20 | 0.33 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.33 |
| ▸ | GAA known ✓ | P10253 | 2/20 | 0.31 |
| ▸ | GRIN2D known ✓ | O15399 | 2/20 | 0.31 |
| ▸ | GRIN1 known ✓ | Q05586 | 2/20 | 0.31 |
| ▸ | GRIN2A known ✓ | Q12879 | 2/20 | 0.31 |
| ▸ | GRIN2B known ✓ | Q13224 | 2/20 | 0.31 |
| ▸ | GRIN2C known ✓ | Q14957 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012096 | 0.98 | CACNA1F (0.33) | CACNA1FOPRK1CACNA1DKCNH2CACNA1S | |
| Hydrochloric Acid SCHEMBL9796807 | 0.76 | KCNN4 (0.36) | CACNA1FOPRK1CACNA1DKCNH2CACNA1S | |
| Hydrochloric Acid SCHEMBL10708769 | 0.74 | KCNN4 (0.35) | CACNA1FOPRK1CACNA1DKCNH2CACNA1S | |
| Hydrochloric Acid SCHEMBL5029119 | 0.71 | SLC6A2 (0.34) | KCNH2SLC6A3 | |
| SCHEMBL5402653 | 0.69 | TDP1 (0.46) | CACNA1FOPRK1CACNA1DKCNH2CACNA1S | |
| SCHEMBL24453542 | 0.67 | CACNA1F (0.43) | CACNA1FOPRK1CACNA1DKCNH2CACNA1S | |
| Hydrochloric Acid SCHEMBL7748984 | 0.67 | SLC6A2 (0.32) | KCNH2 | |
| SCHEMBL9324548 | 0.67 | KDM4E (0.34) | MAPK1GAATAAR1ALDH1A1ALOX15 | |
| Hydrochloric Acid SCHEMBL11534150 | 0.66 | — | — | |
| Hydrochloric Acid SCHEMBL166562 | 0.66 | ELANE (0.36) | KCNH2GAASMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118556090-A | Water-soluble and/or water-swellable hybrid polymers | 科莱恩国际有限公司 | 2024-08-27 | — | — | CN | disclosed |
| CN-116528830-A | Long chain esters for cosmetic treatment of skin | 科莱恩国际有限公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-110300573-B | Use of biobased polymers in cosmetic, dermatological or pharmaceutical compositions | 科莱恩国际有限公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-116419744-A | Opacifying agent composition | 科莱恩国际有限公司 | 2023-07-11 | — | — | CN | disclosed |
| US-9622959-B2 | Cross-linked polymere | CLARIANT INTERNATIONAL LTD. (CH) | 2017-04-18 | — | — | US | disclosed |
| US-9596849-B2 | Composition containing sorbitan monocaprylate and alcohol | CLARIANT INTERNATIONAL LTD. (CH) | 2017-03-21 | — | — | US | disclosed |
| US-20160206542-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITIONS COMBINING COSMETIQUES RETINALDEHYDE AND GLYCYLGLYCINE OLEAMIDE AND THE COSMETIC OR DERMATOLOGICAL USES THEREOF | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2016-07-21 | — | — | US | disclosed |
| US-9101785-B2 | Use of 2,3-dihydroxypropyl dodecanoate for treating seborrhoea | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2015-08-11 | — | — | US | disclosed |
| US-8969390-B2 | Composition containing sorbitan monocaprylate and antimicrobial substances | CLARIANT FINANCE (BVI) LIMITED (VG) | 2015-03-03 | — | — | US | disclosed |
| US-8961944-B2 | Use of delta-tocopheryl-carbohydrate as a depigmenting agent | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2015-02-24 | — | — | US | disclosed |
| US-20120101135-A1 | COMPOSITION CONTAINING SORBITAN MONOCAPRYLATE AND ANTIMICROBIAL SUBSTANCES | CLARIANT FINANCE (BVI) LIMITED (VG) | 2012-04-26 | — | — | US | disclosed |
| US-20120093749-A1 | USE OF DELTA-TOCOPHERYL-CARBOHYDRATE AS A DEPIGMENTING AGENT | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2012-04-19 | — | — | US | disclosed |
| EP-2429485-A2 | USE OF DELTA-TOCOPHERYL-CARBOHYDRATE AS A DEPIGMENTING AGENT | Pierre Fabre Dermo-Cosmétique (FR) | 2012-03-21 | — | — | EP | disclosed |
| US-20110104085-A1 | Cosmetic Or Pharmaceutical Compositions Comprising Modified Polysiloxanes With At Least One Carbamate Group | CLARIANT FINANCE (BVI) LIMITED (VG) | 2011-05-05 | — | — | US | disclosed |
| WO-2010130776-A2 | USE OF DELTA-TOCOPHERYL-CARBOHYDRATE AS A DEPIGMENTING AGENT | PIERRE FABRE DERMO-COSMETIQUE (FR) | 2010-11-18 | — | — | WO | disclosed |
| WO-2009149879-A1 | COSMETIC OR PHARMACEUTICAL COMPOSITIONS COMPRISING MODIFIED POLYSILOXANES WITH AT LEAST ONE CARBAMATE GROUP | CLARIANT INTERNATIONAL LTD (CH) | 2009-12-17 | — | — | WO | disclosed |
| EP-1972330-A2 | Cosmetic or pharmaceutical compositions comprising modified polysiloxanes with at least one carbamate group | CLARIANT INTERNATIONAL LTD. (CH) | 2008-09-24 | — | — | EP | disclosed |
| US-20070031361-A1 | Cosmetic, pharmaceutical and dermatological preparations comprising homopolymer and/or copolymer waxes of the monomers ethylene and/or propylene | HERRMANN HANS-FRIEDRICH | 2007-02-08 | — | — | US | disclosed |
| US-20060188459-A1 | Cosmetic, pharmaceutical or dermatological preparations comprising copolymer waxes | HEINRICHS FRANZ-LEO | 2006-08-24 | — | — | US | disclosed |
| US-20060104940-A1 | Cosmetic, pharmaceutical and dermatological preparations comprising copolymer waxes | CLARIANT GMBH | 2006-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070031361-A1 | Cosmetic, pharmaceutical and dermatological preparations comprising homopolymer and/or copolymer waxes of the monomers ethylene and/or propylene | PMS2, MSH2, PGM2 | CACNA1F 2667/4885OPRK1 3769/4885CACNA1D 2165/4885 |
| US-20060104940-A1 | Cosmetic, pharmaceutical and dermatological preparations comprising copolymer waxes | CUTA, ACMSD, DEGS1 | CACNA1F 3758/4885OPRK1 1609/4885CACNA1D 4259/4885 |
| US-20110104085-A1 | Cosmetic Or Pharmaceutical Compositions Comprising Modified Polysiloxanes With At Least One Carbamate Group | KDM1A, KDM6A, KDM2A | CACNA1F 3284/4885OPRK1 3617/4885CACNA1D 3048/4885 |
| US-20120093749-A1 | USE OF DELTA-TOCOPHERYL-CARBOHYDRATE AS A DEPIGMENTING AGENT | TTPA, ECH1, GLA | CACNA1F 3521/4885OPRK1 3397/4885CACNA1D 3951/4885 |
| US-20060188459-A1 | Cosmetic, pharmaceutical or dermatological preparations comprising copolymer waxes | CUTA, DEGS1, DSG1 | CACNA1F 3104/4885OPRK1 3306/4885CACNA1D 3932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.