Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.48 |
| ▸ | GAA known ✓ | P10253 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2137896 | 0.98 | CA1 (0.50) | CA1CA2CA9RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL3619887 | 0.83 | ALDH1A1 (0.48) | CA1CA2CA9RAB9AMEN1 | |
| SCHEMBL3231268 | 0.80 | ALDH1A1 (0.50) | CA1CA2CA9RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL1584706 | 0.78 | CA1 (0.48) | CA1CA2CA9RAB9AMEN1 | |
| SCHEMBL5768693 | 0.77 | RAB9A (0.47) | RAB9AMEN1KMT2AGAAHTT | |
| Hydrochloric Acid SCHEMBL182337 | 0.77 | CA1 (0.52) | CA1CA2CA9RAB9AGAA | |
| Hydrochloric Acid SCHEMBL30977785 | 0.77 | RAPGEF4 (0.54) | RAB9AMEN1KMT2AGAAHTT | |
| Hydrochloric Acid SCHEMBL29502175 | 0.77 | CA1 (0.52) | CA1CA2CA9RAB9AGAA | |
| Hydrochloric Acid SCHEMBL1012671 | 0.77 | RAPGEF4 (0.54) | RAB9AMEN1KMT2AGAAHTT | |
| Hydrochloric Acid SCHEMBL10966999 | 0.76 | CA1 (0.50) | CA1CA2CA9RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548854-B2 | Heterocyclic compounds as pesticides | BAYER CROPSCIENCE AG (DE) | 2023-01-10 | — | — | US | disclosed |
| US-11332448-B2 | Heterocyclic compounds as pesticides | BAYER CROPSCIENCE AG (DE) | 2022-05-17 | — | — | US | disclosed |
| CN-113243374-B | Heterocyclic compounds as pesticides | 拜耳农作物科学股份公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-113243374-A | Heterocyclic compounds as pesticides | 拜耳农作物科学股份公司 | 2021-08-13 | — | — | CN | disclosed |
| CN-108477173-B | Heterocyclic compounds as pesticides | 拜耳农作物科学股份公司 | 2021-07-02 | — | — | CN | disclosed |
| US-10961201-B2 | Heterocyclic compounds as pesticides | BAYER CROPSCIENCE AG (DE) | 2021-03-30 | — | — | US | disclosed |
| US-20210053924-A1 | HETEROCYCLIC COMPOUNDS AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2021-02-25 | — | — | US | disclosed |
| US-20210017136-A1 | HETEROCYCLIC COMPOUNDS AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2021-01-21 | — | — | US | disclosed |
| US-10689348-B2 | Heterocyclic compounds as pesticides | BAYER CROPSCIENCE AG (DE) | 2020-06-23 | — | — | US | disclosed |
| US-10435374-B2 | Heterocyclic compounds as pesticides | BAYER CROPSCIENCE AG (DE) | 2019-10-08 | — | — | US | disclosed |
| US-6943165-B2 | Compound and method for the treatment of pain | ASTRAZENECA AB (SE) | 2005-09-13 | — | — | US | disclosed |
| US-20050101603-A1 | Compound and method for the treatment of pain | APPLIED ENERGETICS, INC. | 2005-05-12 | — | — | US | disclosed |
| EP-1244662-B1 | PYRIDAZINO QUINOLINE DERIVATIVE AND METHOD FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2005-04-27 | — | — | EP | disclosed |
| US-20040220188-A1 | Alkylidene pyrazolidinedione derivatives | LABORATOIRES SERONO SA (CH) | 2004-11-04 | — | — | US | disclosed |
| US-6787547-B2 | 7-chloro-4-hydroxy-2-(2-chloro-4-methylphenyl)-1,2,5,10 -tetrahydropyridazino(4,5-b)quinoline-1,10-dione; antagonist of N-methyl-d-aspartate (NMDA) receptor; binding to the NMDA receptor glycine site; neuropathic pain; analgesic | ASTRAZENECA AB (SE) | 2004-09-07 | — | — | US | disclosed |
| EP-1399156-A2 | ALKYLIDENE PIRAZOLIDINEDIONE DERIVATIVES AND THEIR USE FOR TREATING DIABETES AND OBESITY | Applied Research Systems ARS Holding N.V. (AN) | 2004-03-24 | — | — | EP | disclosed |
| US-20030149042-A1 | Compound and method for the treatment of pain | BARE THOMAS MICHAEL (US) | 2003-08-07 | — | — | US | disclosed |
| WO-2002102359-A2 | ALKYLIDENE PYRAZOLIDINEDIONE DERIVATIVES AND USE FOR TREATING DIABETES AND OBESITY | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2002-12-27 | — | — | WO | disclosed |
| EP-1244662-A1 | COMPOUND AND METHOD FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047927-A1 | COMPOUND AND METHOD FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2001-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10435374-B2 | Heterocyclic compounds as pesticides | DDT, ACHE, PTMS | CA2 3132/4885GAA 2146/4885CA1 3024/4885 |
| US-10961201-B2 | Heterocyclic compounds as pesticides | DDT, ACHE, PTMS | CA2 3132/4885GAA 2146/4885CA1 3024/4885 |
| US-20030149042-A1 | Compound and method for the treatment of pain | HTR4, QDPR, ACHE | CA2 1404/4885GAA 1888/4885CA1 1789/4885 |
| US-10689348-B2 | Heterocyclic compounds as pesticides | DDT, ACHE, PTMS | CA2 3132/4885GAA 2146/4885CA1 3024/4885 |
| US-20040220188-A1 | Alkylidene pyrazolidinedione derivatives | G6PC1, PPM1D, PTPRS | CA2 4540/4885GAA 3191/4885CA1 4776/4885 |
| US-11548854-B2 | Heterocyclic compounds as pesticides | DDT, ACHE, PTMS | CA2 3132/4885GAA 2146/4885CA1 3024/4885 |
| US-20210053924-A1 | HETEROCYCLIC COMPOUNDS AS PESTICIDES | DDT, ACHE, PTMS | CA2 3132/4885GAA 2146/4885CA1 3024/4885 |
| US-11332448-B2 | Heterocyclic compounds as pesticides | DDT, ACHE, PTMS | CA2 3132/4885GAA 2146/4885CA1 3024/4885 |
| US-20210017136-A1 | HETEROCYCLIC COMPOUNDS AS PESTICIDES | DDT, ACHE, PTMS | CA2 3132/4885GAA 2146/4885CA1 3024/4885 |
| US-20050101603-A1 | Compound and method for the treatment of pain | ACHE, OPRK1, OPRL1 | CA2 711/4885GAA 1995/4885CA1 1158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.